KEGG   DRUG: Alfuzosin hydrochloride
Entry
D01692                      Drug                                   
Name
Alfuzosin hydrochloride (JAN/USAN);
Uroxatral (TN)
Product
UROXATRAL (Concordia Pharmaceuticals)
  Generic
ALFUZOSIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), ALFUZOSIN HYDROCHLORIDE (Aurobindo Pharma Limited), ALFUZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), ALFUZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), ALFUZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), ALFUZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), ALFUZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), ALFUZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), ALFUZOSIN HYDROCHLORIDE (Bryant Ranch Prepack), ALFUZOSIN HYDROCHLORIDE (Cipla USA), ALFUZOSIN HYDROCHLORIDE (Denton Pharma), ALFUZOSIN HYDROCHLORIDE (Exelan Pharmaceuticals), ALFUZOSIN HYDROCHLORIDE (Rising Health), ALFUZOSIN HYDROCHLORIDE (Sun Pharmaceutical Industries), ALFUZOSIN HYDROCHLORIDE (Unichem Pharmaceuticals (USA)), ALFUZOSIN HYDROCHLORIDE (Wockhardt USA LLC.)
Formula
C19H27N5O4. HCl
Exact mass
425.183
Mol weight
425.9097
Structure
Simcomp
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01457  alpha1-Adrenergic receptor antagonist
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: G04CA01
Chemical structure group: DG00489
Product (DG00489): D01692<US>
Efficacy
Antidysuria, Antihypertensive, alpha1-Adrenergic receptor antagonist
Comment
Prazosin derivative
Target
ADRA1A [HSA:148] [KO:K04135]
  Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04C DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
    G04CA Alpha-adrenoreceptor antagonists
     G04CA01 Alfuzosin
      D01692  Alfuzosin hydrochloride (JAN/USAN) <US>
USP drug classification [BR:br08302]
 Genitourinary Agents
  Benign Prostatic Hypertrophy Agents
   Alfuzosin
    D01692  Alfuzosin hydrochloride (JAN/USAN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01466  Adrenergic receptor antagonist
   DG01465  alpha-Adrenergic receptor antagonist
    DG01457  alpha1-Adrenergic receptor antagonist
     DG00489  Alfuzosin
      D01692  Alfuzosin hydrochloride
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00489  Alfuzosin
     D01692  Alfuzosin hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1A
     D01692  Alfuzosin hydrochloride (JAN/USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01692
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01692
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01692
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01466  Adrenergic receptor antagonist
   DG01465  alpha-Adrenergic receptor antagonist
    DG01457  alpha1-Adrenergic receptor antagonist
     DG00489  Alfuzosin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00489  Alfuzosin
Other DBs
CAS: 81403-68-1
PubChem: 7848755
ChEBI: 32286
LigandBox: D01692
NIKKAJI: J346.511J
LinkDB
KCF data

ATOM        29
            1   C8y C    21.4500  -13.4748
            2   C8y C    21.4500  -12.0658
            3   C8x C    22.6778  -14.1822
            4   C8y C    20.2397  -14.1822
            5   N5x N    20.2397  -11.3817
            6   C8x C    22.6778  -11.3817
            7   C8y C    23.8821  -13.4748
            8   N5x N    19.0294  -13.4748
            9   N1a N    20.2397  -15.5855
            10  C8y C    19.0294  -12.0658
            11  C8y C    23.8821  -12.0658
            12  O2a O    25.1158  -14.1822
            13  N1c N    17.8190  -11.3817
            14  O2a O    25.1158  -11.3817
            15  C1a C    26.3203  -13.4689
            16  C1b C    16.5970  -12.0658
            17  C1a C    26.3203  -12.0774
            18  C1a C    17.8219   -9.9828
            19  C1b C    15.3948  -11.3505
            20  C1b C    14.1744  -12.0339
            21  N1b N    12.9722  -11.3186
            22  C5a C    11.7517  -12.0019
            23  O5a O    11.7799  -13.4006
            24  C1y C    10.5565  -11.3311
            25  C1x C    10.1211  -10.0016
            26  O2x O     9.4217  -12.1564
            27  C1x C     8.2870  -11.3311
            28  C1x C     8.7223  -10.0016
            29  X   Cl   29.5439  -12.6330
BOND        30
            1     7  12 1
            2    10  13 1
            3    11  14 1
            4    12  15 1
            5    13  16 1
            6    14  17 1
            7     7  11 1
            8     8  10 1
            9    13  18 1
            10   16  19 1
            11    1   2 2
            12   19  20 1
            13    1   3 1
            14   20  21 1
            15    1   4 1
            16   21  22 1
            17    2   5 1
            18   22  23 2
            19    2   6 1
            20   22  24 1
            21    3   7 2
            22    4   8 2
            23    4   9 1
            24    5  10 2
            25   25  24 1
            26   24  26 1
            27   26  27 1
            28   27  28 1
            29   28  25 1
            30    6  11 2

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