Entry |
|
Name |
Brotizolam (JP18/USAN/INN); Lendormin (TN) |
Formula |
C15H10BrClN4S
|
Exact mass |
391.9498
|
Mol weight |
393.6887
|
Structure |

|
Simcomp |
|
Class |
Neuropsychiatric agent
DG01835 Benzodiazepine sedative-hypnotics
DG03202 Hypnotic
DG01567 GABA-A receptor agonist
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
Remark |
Therapeutic category: | 1124 |
|
Efficacy |
Sedative-hypnotic |
Comment |
Benzodiazepine derivative (thienodiazepine)
|
Target |
|
Pathway |
hsa04080 | Neuroactive ligand-receptor interaction |
|
Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
Interaction |
|
Structure map |
map07230 | GABA-A receptor agonists/antagonists |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05C HYPNOTICS AND SEDATIVES
N05CD Benzodiazepine derivatives
N05CD09 Brotizolam
D01744 Brotizolam (JP18/USAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
112 Hypnotics and sedatives, anxiolytics
1124 Benzodiazepins
D01744 Brotizolam (JP18/USAN/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01835 Benzodiazepine sedative-hypnotics
D01744 Brotizolam
DG03202 Hypnotic
D01744 Brotizolam
DG01567 GABA-A receptor agonist
D01744 Brotizolam
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D01744 Brotizolam
Drug classes [BR:br08332]
Neuropsychiatric agent
DG03202 Hypnotic
D01744 Brotizolam
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
GABA (ionotropic)
GABR
D01744 Brotizolam (JP18/USAN/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01744 Brotizolam
D01744 Brotizolam tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01744
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 22
1 C2y C 19.2256 -17.0277
2 C8y C 18.3366 -15.9534
3 C8y C 18.6148 -14.5824
4 N4y N 19.8517 -13.9512
5 N2x N 20.6326 -16.9938
6 C8y C 21.1316 -14.5209
7 C1x C 21.4758 -15.8776
8 C8y C 18.6425 -18.3050
9 C8x C 17.2396 -18.3200
10 C8x C 16.5511 -19.5426
11 C8x C 17.2656 -20.7501
12 C8x C 18.6685 -20.7351
13 C8y C 19.3570 -19.5125
14 X Cl 20.7814 -19.4974
15 S2x S 17.4668 -13.8942
16 C8y C 16.4359 -14.8399
17 C8x C 17.0138 -15.9725
18 N5x N 22.0689 -13.4795
19 N5x N 21.3682 -12.2663
20 C8y C 19.9979 -12.5578
21 X Br 14.9661 -14.5703
22 C1a C 18.9516 -11.6159
BOND 25
1 3 4 1
2 1 5 2
3 4 6 1
4 2 3 2
5 5 7 1
6 1 2 1
7 6 7 1
8 1 8 1
9 8 9 2
10 9 10 1
11 10 11 2
12 11 12 1
13 12 13 2
14 8 13 1
15 13 14 1
16 3 15 1
17 15 16 1
18 16 17 2
19 2 17 1
20 6 18 2
21 18 19 1
22 19 20 2
23 4 20 1
24 16 21 1
25 20 22 1
|