| Entry |
|
|---|
| Name |
Bunazosin hydrochloride (JP18);
Detantol (TN) |
|---|
| Formula |
C19H27N5O3. HCl
|
|---|
| Exact mass |
409.1881
|
|---|
| Mol weight |
409.91
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01457 alpha1-Adrenergic receptor antagonist
DG03231 Antihypertensive
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
|
|---|
| Remark |
| Product (DG01316): | D01887<JP> |
|
|---|
| Efficacy |
Antiglaucoma, Antihypertensive, alpha1-Adrenergic receptor antagonist |
|---|
| Comment |
Prazosin derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07215 | alpha-Adrenergic receptor agonists/antagonists |
|
|---|
| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
13 Agents affecting sensory organs
131 Ophthalmic agents
1319 Others
D01887 Bunazosin hydrochloride (JP18)
2 Agents affecting individual organs
21 Cardiovascular agents
214 Antihypertensives
2149 Others
D01887 Bunazosin hydrochloride (JP18)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01457 alpha1-Adrenergic receptor antagonist
DG01316 Bunazosin
D01887 Bunazosin hydrochloride
DG03231 Antihypertensive
DG01316 Bunazosin
D01887 Bunazosin hydrochloride
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG01316 Bunazosin
D01887 Bunazosin hydrochloride
Drug classes [BR:br08332]
Cardiovascular agent
DG03231 Antihypertensive
D01887 Bunazosin hydrochloride
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
D01887 Bunazosin hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D01887 Bunazosin hydrochloride (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01887 Bunazosin hydrochloride
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01457 alpha1-Adrenergic receptor antagonist
DG01316 Bunazosin
DG03231 Antihypertensive
DG01316 Bunazosin
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG01316 Bunazosin
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 28
1 C8y C 27.9136 -16.0282
2 C8y C 27.9136 -17.4318
3 C8x C 26.6951 -18.1336
4 C8x C 26.6951 -15.3264
5 C8y C 25.4837 -16.0282
6 C8y C 25.4897 -17.4318
7 C8y C 24.2771 -18.1387
8 N5x N 23.0586 -17.4421
9 C8y C 23.0527 -16.0386
10 N5x N 24.2652 -15.3315
11 N1y N 21.8342 -15.3419
12 C1x C 21.8344 -13.9492
13 C1x C 20.8946 -12.9945
14 C1x C 20.6712 -16.1391
15 N1y N 19.5086 -13.2011
16 C1x C 19.3269 -15.7273
17 C1x C 18.8144 -14.4187
18 C5a C 18.8185 -11.9875
19 C1b C 17.4219 -11.9875
20 C1b C 16.7272 -10.7753
21 C1a C 15.3308 -10.7753
22 O5a O 19.5243 -10.7743
23 O2a O 29.1288 -15.3257
24 C1a C 30.3446 -16.0268
25 O2a O 29.1288 -18.1341
26 C1a C 30.3446 -17.4330
27 N1a N 24.2831 -19.5423
28 X Cl 17.6363 -18.0733
BOND 29
1 12 13 1
2 1 2 2
3 11 14 1
4 2 3 1
5 13 15 1
6 3 6 2
7 14 16 1
8 5 4 2
9 15 17 1
10 16 17 1
11 5 6 1
12 15 18 1
13 6 7 1
14 18 19 1
15 7 8 2
16 19 20 1
17 8 9 1
18 20 21 1
19 9 10 2
20 18 22 2
21 10 5 1
22 1 23 1
23 4 1 1
24 23 24 1
25 9 11 1
26 2 25 1
27 25 26 1
28 11 12 1
29 7 27 1
|
|---|
