KEGG   DRUG: Cilostazol
Entry
D01896                      Drug                                   
Name
Cilostazol (JP18/USP/INN);
Pletal (TN)
Product
  Generic
Formula
C20H27N5O2
Exact mass
369.2165
Mol weight
369.4607
Structure
Class
Cardiovascular agent
 DG01507  Phosphodiesterase III inhibitor
Blood modifier agent
 DG01950  Antithrombotic agent
  DG01712  Antiplatelet agent
Metabolizing enzyme substrate
 DG01639  CYP2C19 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 3399
ATC code: B01AC23
Product: D01896<JP/US>
Efficacy
Vasodilator, Platelet aggregation inhibitor, Phosphodiesterase inhibitor
Target
PDE3 [HSA:5139 5140] [KO:K19021 K13296]
TBXA2R [HSA:6915] [KO:K04264]
  Pathway
hsa00230  Purine metabolism
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04611  Platelet activation
hsa04910  Insulin signaling pathway
hsa04922  Glucagon signaling pathway
Metabolism
Enzyme: CYP3A4 [HSA:1576]; CYP2D6 [HSA:1565], CYP2C19 [HSA:1557]
Interaction
Structure map
map07049  Antithrombosis agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AC Platelet aggregation inhibitors excl. heparin
     B01AC23 Cilostazol
      D01896  Cilostazol (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Blood Products and Modifiers
  Platelet Modifying Agents
   Platelet Modifying Agents, Other
    Cilostazol
     D01896  Cilostazol (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   339  Miscellaneous
    3399  Others
     D01896  Cilostazol (JP18/USP/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01507  Phosphodiesterase III inhibitor
   D01896  Cilostazol
 Blood modifier agent
  DG01950  Antithrombotic agent
   DG01712  Antiplatelet agent
    D01896  Cilostazol
 Metabolizing enzyme substrate
  DG01639  CYP2C19 substrate
   D01896  Cilostazol
  DG01644  CYP2D6 substrate
   D01896  Cilostazol
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D01896  Cilostazol
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Thromboxane
    TBXA2R
     D01896  Cilostazol (JP18/USP/INN) <JP/US>
 Enzymes
  Hydrolases (EC3)
   Phosphodiesterases
    PDE3
     D01896  Cilostazol (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01896  Cilostazol
  D01896  Cilostazol tablets
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01896
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01896
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01896
Other DBs
CAS: 73963-72-1
PubChem: 7848958
ChEBI: 31401
LigandBox: D01896
NIKKAJI: J23.223H
LinkDB
KCF data

ATOM        27
            1   C1y C    21.6291  -13.6161
            2   C1x C    21.6291  -15.0158
            3   C1x C    20.4140  -15.7157
            4   C1x C    19.2060  -15.0158
            5   C1x C    19.2060  -13.6161
            6   C1x C    20.4140  -12.9162
            7   N4y N    22.8410  -12.9155
            8   C8y C    22.8310  -11.5237
            9   N5x N    24.1537  -11.0795
            10  N5x N    24.9846  -12.2002
            11  N5x N    24.1756  -13.3370
            12  C8y C    13.1531  -11.4954
            13  C8y C    13.1600  -12.9021
            14  N1x N    11.9445  -13.6081
            15  C5x C    10.7217  -12.9144
            16  C1x C    10.7146  -11.5078
            17  C1x C    11.9303  -10.7947
            18  C8y C    15.5755  -11.5086
            19  C8x C    15.5771  -12.9086
            20  C8x C    14.3572  -13.6076
            21  C8x C    14.3592  -10.7940
            22  O5x O     9.5059  -13.6203
            23  O2a O    16.7868  -10.8096
            24  C1b C    17.9956  -11.5095
            25  C1b C    19.2045  -10.8167
            26  C1b C    20.4133  -11.5166
            27  C1b C    21.6222  -10.8239
BOND        30
            1     1   7 1
            2     1   2 1
            3     2   3 1
            4     3   4 1
            5     4   5 1
            6     7   8 1
            7     8   9 2
            8     9  10 1
            9    13  14 1
            10   18  19 1
            11   19  20 2
            12   20  13 1
            13   12  21 1
            14   21  18 2
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   17  12 1
            19   12  13 2
            20   15  22 2
            21   10  11 2
            22   18  23 1
            23   11   7 1
            24   23  24 1
            25    5   6 1
            26   24  25 1
            27    6   1 1
            28   25  26 1
            29   26  27 1
            30   27   8 1

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