KEGG   DRUG: Fludarabine phosphateHelp
Entry
D01907                      Drug                                   

Name
Fludarabine phosphate (JAN/USP);
Fludara (TN)
Product
  Generic
Formula
C10H13FN5O7P
Exact mass
365.0537
Mol weight
365.2117
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antineoplastic
 DG01958  Nucleic acid derivative, antineoplastic
  DG01439  Arabinofuranosyl type antineoplastic
 DG01439  Arabinofuranosyl type antineoplastic
 DG02018  Antimetabolite
  DG01958  Nucleic acid derivative, antineoplastic
   DG01439  Arabinofuranosyl type antineoplastic
Remark
Therapeutic category: 4229
ATC code: L01BB05
Chemical structure group: DG00685
Product (DG00685): D01907<JP/US>
Efficacy
Antineoplastic, Antimetabolite
  Disease
B-cell chronic lymphocytic leukemia [DS:H00005]
Comment
Active form of prodrug: Fludarabine [DR:D07966]
Target
RRM1 [HSA:6240] [KO:K10807]
DNA polymerase
RNA polymerase
  Pathway
hsa00230  Purine metabolism
hsa00240  Pyrimidine metabolism
Interaction
Drug interaction
Structure map
map07041  Antineoplastics - antimetabolic agents
map07044  Antiviral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01B ANTIMETABOLITES
    L01BB Purine analogues
     L01BB05 Fludarabine
      D01907  Fludarabine phosphate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Antineoplastics, Other
   Fludarabine
    D01907  Fludarabine phosphate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   422  Antimetabolites
    4229  Others
     D01907  Fludarabine phosphate (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Ribonucleoside-diphosphate reductase
    RRM1
     D01907  Fludarabine phosphate (JAN/USP) <JP/US>
Antineoplastics [br08340.html]
 D01907
Prodrugs [br08324.html]
 D01907
BRITE hierarchy
Other DBs
CAS: 75607-67-9
PubChem: 7848969
ChEBI: 63599
ChEMBL: CHEMBL1096882
DrugBank: DB01073
LigandBox: D01907
NIKKAJI: J535.382C
LinkDB All DBs
KCF data Show

ATOM        24
            1   C1y C    11.4800  -11.6200
            2   C1y C    12.8800  -11.6200
            3   C1y C    13.3126  -10.2885
            4   O2x O    12.1800   -9.4656
            5   C1y C    11.0474  -10.2885
            6   O1a O    10.7800  -12.8324
            7   O1a O    13.5800  -12.8324
            8   N5x N    15.7375  -11.6885
            9   C8y C    15.7375  -10.2885
            10  N4y N    14.5251   -9.5885
            11  C1b C     9.8349   -9.5885
            12  O2b O     8.6225  -10.2885
            13  C8y C    16.9499  -12.3885
            14  N5x N    18.1624  -11.6885
            15  C8y C    18.1624  -10.2885
            16  C8y C    16.9499   -9.5885
            17  N5x N    16.6589   -8.2191
            18  C8x C    15.2665   -8.0727
            19  N1a N    19.3497   -9.6027
            20  X   F    16.9499  -13.7900
            21  P1b P     7.2225  -10.2885
            22  O1c O     5.8225  -10.2885
            23  O1c O     7.2225   -8.8901
            24  O1c O     7.2225  -11.6899
BOND        26
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     1   6 1 #Down
            7     2   7 1 #Up
            8     8   9 1
            9     9  10 1
            10    3  10 1 #Up
            11    5  11 1 #Up
            12   11  12 1
            13    8  13 2
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17    9  16 2
            18   16  17 1
            19   17  18 2
            20   18  10 1
            21   15  19 1
            22   13  20 1
            23   12  21 1
            24   21  22 1
            25   21  23 2
            26   21  24 1

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