Chronic lymphocytic leukemia (CLL) is caused by the abnormal progressive accumulation of functionally incompetent monoclonal B-lymphocytes in blood, bone marrow, lymph nodes and spleen. It is the most common adult leukemia in Western countries, accounting for about 30% of total leukaemias. Worldwide there are approximately 180,000 new cases every year. A main focus in CLL research involved the evaluation of genetic features related to somatic gene mutation or deletions that disrupt apoptosis and enhance tumor cell proliferation. The best characterized genes are TP53 (also known as p53) and ATM, for which mutations and/or deletions have been described that predict rapid disease progression, resistance to conventional therapies and poor survival.
Category
Cancer
Brite
Human diseases [BR:br08402]
Cancers
Cancers of haematopoietic and lymphoid tissues
H00005 Chronic lymphocytic leukemia
Human diseases in ICD-11 classification [BR:br08403]
02 Neoplasms
Neoplasms of haematopoietic or lymphoid tissues
Mature B-cell neoplasms
2A82 Mature B-cell neoplasm with leukaemic behaviour
H00005 Chronic lymphocytic leukemia
Tumor markers [br08442.html]
H00005
Cancer-associated carbohydrates [br08441.html]
H00005
