KEGG   DRUG: Brimonidine tartrateHelp
Entry
D02076                      Drug                                   

Name
Brimonidine tartrate (JAN/USAN);
Alphagan (TN)
Product
  Generic
Formula
C11H10BrN5. C4H6O6
Exact mass
441.0284
Mol weight
442.2214
Structure
Mol fileKCF fileDB search
Class
Cardiovascular agent
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
    DG01655  alpha2-adrenergic receptor specific agonist
Remark
Therapeutic category: 1319
ATC code: D11AX21 S01EA05
Chemical structure group: DG00442
Product (DG00442): D02076<JP/US>
Product (mixture): D10298<US> D10854<US>
Efficacy
Antiglaucoma, alpha-Adrenergic receptor agonist
  Disease
Open-angle glaucoma [DS:H00612]
Comment
Clonidine derivative
Target
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07054  Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D11 OTHER DERMATOLOGICAL PREPARATIONS
   D11A OTHER DERMATOLOGICAL PREPARATIONS
    D11AX Other dermatologicals
     D11AX21 Brimonidine
      D02076  Brimonidine tartrate (JAN/USAN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EA Sympathomimetics in glaucoma therapy
     S01EA05 Brimonidine
      D02076  Brimonidine tartrate (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Acne and Rosacea Agents
   Acne and Rosea, Other
    Brimonidine
     D02076  Brimonidine tartrate (JAN/USAN)
 Ophthalmic Agents
  Intraocular Pressure Lowering Agents
   Alpha-adrenergic Agonists, Ophthalmic
    Brimonidine
     D02076  Brimonidine tartrate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D02076  Brimonidine tartrate (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2
     D02076  Brimonidine tartrate (JAN/USAN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D02076
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02076
BRITE hierarchy
Other DBs
CAS: 79570-19-7
PubChem: 7849138
ChEBI: 51157
DrugBank: DB00484
LigandBox: D02076
LinkDB All DBs
KCF data Show

ATOM        27
            1   O6a O    21.8870  -16.5436
            2   C6a C    23.0994  -15.8436
            3   C1c C    24.3119  -16.5436
            4   C1c C    25.5244  -15.8436
            5   C6a C    26.7368  -16.5436
            6   O6a O    27.9492  -15.8436
            7   O6a O    23.1003  -14.4436
            8   O6a O    26.7404  -17.9435
            9   O1a O    24.3119  -17.9435
            10  O1a O    25.5244  -14.4436
            11  C8x C     9.7300  -16.3100
            12  C8x C     9.7300  -17.7100
            13  N5x N    10.9424  -18.4100
            14  C8y C    12.1549  -17.7100
            15  C8y C    12.1549  -16.3100
            16  N5x N    10.9424  -15.6100
            17  C8x C    13.3673  -18.4100
            18  C8x C    14.5797  -17.7100
            19  C8y C    14.5797  -16.3100
            20  C8y C    13.3673  -15.6100
            21  N2x N    17.0046  -17.7100
            22  C2y C    17.0046  -16.3100
            23  N1b N    15.7922  -15.6100
            24  C1x C    18.3361  -18.1426
            25  C1x C    19.1590  -17.0100
            26  N1x N    18.3361  -15.8774
            27  X   Br   13.3673  -14.2100
BOND        28
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     2   7 2
            7     5   8 2
            8     3   9 1 #Up
            9     4  10 1 #Up
            10   11  12 2
            11   12  13 1
            12   13  14 2
            13   14  15 1
            14   15  16 2
            15   11  16 1
            16   14  17 1
            17   17  18 2
            18   18  19 1
            19   19  20 2
            20   15  20 1
            21   21  22 2
            22   22  23 1
            23   19  23 1
            24   21  24 1
            25   24  25 1
            26   25  26 1
            27   22  26 1
            28   20  27 1

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