KEGG   DRUG: Levcromakalim
Entry
D02385                      Drug                                   

Name
Levcromakalim (USAN/INN);
Lemakalim
Formula
C16H18N2O3
Exact mass
286.1317
Mol weight
286.3257
Structure
Simcomp
Class
Cardiovascular agent
 DG01583  ATP-sensitive potassium channel opener
Remark
Same as: C11697
Efficacy
Antiasthmatic, Antihypertensive
Target
ABCC8(SUR1)/KCNJ11(KIR6.2) [HSA:6833 3767] [KO:K05032 K05004]
ABCC9(SUR2)/KCNJ11(KIR6.2) [HSA:10060 3767] [KO:K05033 K05004]
  Pathway
hsa02010  ABC transporters
Structure map
map07232  Potassium channel blocking and opening drugs
Brite
Target-based classification of drugs [BR:br08310]
 Transporters
  ABC transporters
   ABCC subfamily
    ABCC8(SUR1)/KCNJ11(KIR6.2)
     D02385  Levcromakalim (USAN/INN)
    ABCC9(SUR2)/KCNJ11(KIR6.2)
     D02385  Levcromakalim (USAN/INN)
Other DBs
CAS: 94535-50-9
PubChem: 7849444
ChEBI: 6436
ChEMBL: CHEMBL100
LigandBox: D02385
NIKKAJI: J257.580I
LinkDB
KCF data

ATOM        21
            1   O2x O    18.8220  -15.3856
            2   C1z C    20.0267  -14.6877
            3   C1y C    20.0267  -13.2917
            4   C1y C    18.8220  -12.5938
            5   N1y N    18.8237  -11.1979
            6   C5x C    19.9576  -10.3721
            7   C1x C    19.5280   -9.0438
            8   C1x C    18.1321   -9.0421
            9   C1x C    17.6990  -10.3692
            10  O5x O    21.1921  -10.9896
            11  C8y C    17.6101  -14.6877
            12  C8y C    17.6101  -13.2917
            13  C8x C    16.4012  -12.5938
            14  C8y C    15.1922  -13.2917
            15  C8x C    15.1922  -14.6877
            16  C8x C    16.4012  -15.3856
            17  C3b C    13.9836  -12.5938
            18  N3a N    12.7850  -11.8747
            19  C1a C    21.1894  -15.5709
            20  C1a C    21.2734  -14.0291
            21  O1a O    21.2360  -12.5481
BOND        23
            1     4  12 1
            2     6  10 2
            3     4   5 1 #Up
            4    11   1 1
            5     1   2 1
            6     2   3 1
            7     3   4 1
            8    11  12 1
            9    12  13 2
            10   13  14 1
            11   14  15 2
            12   15  16 1
            13   16  11 2
            14    5   6 1
            15   14  17 1
            16    6   7 1
            17   17  18 3
            18    7   8 1
            19    2  19 1
            20    8   9 1
            21    2  20 1
            22    9   5 1
            23    3  21 1 #Down

» Japanese version   » Back

DBGET integrated database retrieval system