KEGG   DRUG: MaprotilineHelp
Entry
D02566                      Drug                                   

Name
Maprotiline (USAN)
Formula
C20H23N
Exact mass
277.1831
Mol weight
277.4033
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01730  Non-selective monoamine reuptake inhibitor
 DG01729  Tetracyclic antidepressant
Enzyme substrate
 DG01644  CYP2D6 substrate
Remark
Same as: C07107
ATC code: N06AA21
Chemical structure group: DG00941
Product (DG00941): D00818<JP/US>
Efficacy
Antidepressant, Selective noradrenaline reuptake inhibitor (NRI)
Target
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
map07027  Antidepressants
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AA Non-selective monoamine reuptake inhibitors
     N06AA21 Maprotiline
      D02566  Maprotiline (USAN)
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Maprotiline
    D02566  Maprotiline (USAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D02566  Maprotiline (USAN)
BRITE hierarchy
Other DBs
CAS: 10262-69-8
PubChem: 17396737
ChEBI: 6690
ChEMBL: CHEMBL1201257 CHEMBL21731
DrugBank: DB00934
LigandBox: D02566
NIKKAJI: J9.818C
LinkDB All DBs
KCF data Show

ATOM        21
            1   C1x C    21.9568  -16.7489
            2   C1x C    21.9568  -17.8749
            3   C1z C    21.4642  -15.8341
            4   C8y C    20.1975  -16.5378
            5   C8y C    22.7309  -16.5378
            6   C1b C    21.4642  -14.3563
            7   C8y C    20.1975  -17.9452
            8   C8x C    19.0012  -15.7637
            9   C8y C    22.7309  -18.0156
            10  C8x C    23.9976  -15.8341
            11  C1b C    22.7309  -13.6525
            12  C1y C    21.4642  -18.7193
            13  C8x C    18.9308  -18.6490
            14  C8x C    17.7345  -16.4674
            15  C8x C    23.9272  -18.7193
            16  C8x C    25.2643  -16.6082
            17  C1b C    23.9272  -14.4266
            18  C8x C    17.7345  -17.9452
            19  C8x C    25.2643  -18.0156
            20  N1b N    25.2643  -13.7229
            21  C1a C    26.5310  -14.4266
BOND        24
            1     1   2 1
            2     3   4 1
            3     3   5 1
            4     3   6 1
            5     4   7 1
            6     4   8 2
            7     5   9 2
            8     5  10 1
            9     6  11 1
            10    7  12 1
            11    7  13 2
            12    8  14 1
            13    9  15 1
            14   10  16 2
            15   11  17 1
            16   13  18 1
            17   15  19 2
            18   17  20 1
            19   20  21 1
            20    9  12 1
            21   14  18 2
            22   16  19 1
            23    2  12 1
            24    1   3 1

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