KEGG ORTHOLOGY: K05035

ORTHOLOGY: K05035

Entry

K05035                      KO

Symbol

SLC6A2, NET

Name

solute carrier family 6 (neurotransmitter transporter, noradrenalin) member 2

Pathway

map04082

Neuroactive ligand signaling

map04721

Synaptic vesicle cycle

Disease

H01031

Orthostatic intolerance

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    K05035  SLC6A2, NET; solute carrier family 6 (neurotransmitter transporter, noradrenalin) member 2
09150 Organismal Systems
  09156 Nervous system
   04721 Synaptic vesicle cycle
    K05035  SLC6A2, NET; solute carrier family 6 (neurotransmitter transporter, noradrenalin) member 2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K05035  SLC6A2, NET; solute carrier family 6 (neurotransmitter transporter, noradrenalin) member 2
Transporters [BR:ko02000]
Solute carrier family (SLC)
  SLC6: Sodium- and chloride-dependent neurotransmitter transporter
   K05035  SLC6A2, NET; solute carrier family 6 (neurotransmitter transporter, noradrenalin) member 2

Other DBs

GO:

0005334

TC:	2.A.22.1.2

Genes

HSA:	6530(SLC6A2)

PTR:	454096(SLC6A2)

PPS:	100969706(SLC6A2)

GGO:	101149127(SLC6A2)

PON:	100450297(SLC6A2)

PPYG:

129015012(SLC6A2)

NLE:	100598446(SLC6A2)

HMH:	116470438(SLC6A2)

SSYN:

129492948(SLC6A2)

MCC:	613238(SLC6A2)

MCF:	102126245(SLC6A2)

MTHB:

126943957

MNI:	105494114(SLC6A2)

CSAB:

103233011(SLC6A2)

CATY:

105588528(SLC6A2)

PANU:

101014527(SLC6A2)

TGE:	112614206(SLC6A2)

MLEU:

105533442(SLC6A2)

RRO:	104671478(SLC6A2)

RBB:	108526380(SLC6A2)

TFN:	117087801(SLC6A2)

PTEH:

111541199(SLC6A2)

CJC:	100388661(SLC6A2)

SBQ:	101043156(SLC6A2)

CIMI:

108305430(SLC6A2)

ANAN:

105714063(SLC6A2)

CSYR:

103249351(SLC6A2)

MMUR:

105866562(SLC6A2)

LCAT:

123625077(SLC6A2)

ERUF:

138373758(SLC6A2)

PCOQ:

105825014(SLC6A2)

OGA:	100965835(SLC6A2)

MMU:	20538(Slc6a2)

MCAL:

110299880(Slc6a2)

MPAH:

110337413(Slc6a2)

RNO:	83511(Slc6a2)

MCOC:

116069872(Slc6a2)

ANU:	117723165(Slc6a2)

ASYL:

127671745(Slc6a2)

MUN:	110565374(Slc6a2)

CGE:	100773003(Slc6a2)

MAUA:

101833084(Slc6a2)

PROB:

127230008(Slc6a2)

PLEU:

114694530(Slc6a2)

PMAV:

102926735(Slc6a2)

MORG:

121447315(Slc6a2)

MFOT:

126502995

AAMP:

119802100(Slc6a2)

CNL:	130863310(Slc6a2)

NGI:	103731685(Slc6a2)

HGL:	101716834(Slc6a2)

CPOC:

100723578(Slc6a2)

CCAN:

109677461(Slc6a2)

DORD:

105994424(Slc6a2)

DSP:	122116296(Slc6a2)

DMER:

138806902(Slc6a2)

PLOP:

125358440(Slc6a2)

NCAR:

124967582

MMMA:

107144861(Slc6a2)

ITI:	101971558(Slc6a2)

OCU:

100341516

OPI:	101523756(SLC6A2)

OCZ:	121158076(SLC6A2)

TUP:	102480674(SLC6A2)

GVR:	103609097(SLC6A2)

CFA:	487272(SLC6A2)

CLUD:

112660398(SLC6A2)

VVP:	112929593(SLC6A2)

VLG:	121496529(SLC6A2)

NPO:	129513762(SLC6A2)

AML:	100465372(SLC6A2)

UMR:	103673899(SLC6A2)

UAH:	113251701(SLC6A2)

UAR:	123798364(SLC6A2)

ELK:

111157387

LLV:

125089886

MPUF:

101676068(SLC6A2)

MNP:	132004869(SLC6A2)

MLK:	131818921(SLC6A2)

NVS:	122913788(SLC6A2)

ORO:	101377561(SLC6A2)

EJU:	114203110(SLC6A2)

ZCA:	113936711(SLC6A2)

MLX:	118023775(SLC6A2)

MANO:

123855457(SLC6A2)

NSU:	110593354(SLC6A2)

FCA:	101099605(SLC6A2)

PYU:	121045322(SLC6A2)

PCOO:

112857296(SLC6A2)

PBG:	122494222(SLC6A2)

PVIV:

125153121(SLC6A2)

LRUF:

124511831

LGF:	123579172(SLC6A2)

AJU:

106973283

PTG:	102957236(SLC6A2)

PPAD:

109270895(SLC6A2)

PUC:

125915405

PLEZ:

122208695(SLC6A2)

HHV:	120238319(SLC6A2)

CCRU:

144220968(SLC6A2)

BTA:	282363(SLC6A2)

BOM:	102268122(SLC6A2)

BIU:	109573009(SLC6A2)

BBUB:

102400089(SLC6A2)

BKE:	129631223(SLC6A2)

BBIS:

105004333(SLC6A2)

CHX:	102185209(SLC6A2)

OAS:	101116078(SLC6A2)

BTAX:

128063516(SLC6A2)

CSUM:

138096315(SLC6A2)

ODA:	120873206(SLC6A2)

CCAD:

122420765(SLC6A2)

MREE:

136158675(SLC6A2)

OVR:	110141578(SLC6A2)

MBEZ:

129547091(SLC6A2)

SSC:	100517716(SLC6A2)

CFR:	102509520(SLC6A2)

CBAI:

105075735(SLC6A2)

CDK:	105097503(SLC6A2)

VPC:	102534910(SLC6A2)

BACU:

103015690(SLC6A2)

BMUS:

118885342(SLC6A2)

LVE:	103070925(SLC6A2)

OOR:	101276222(SLC6A2)

LALB:

132510514(SLC6A2)

GMF:	115840281(SLC6A2)

DDP:	132416820(SLC6A2)

DLE:	111165009(SLC6A2)

PCAD:

102996749(SLC6A2)

PSIU:

116744135(SLC6A2)

PPHC:

136140378(SLC6A2)

NASI:

112401265(SLC6A2)

ECB:	100061346(SLC6A2)

EPZ:	103553193(SLC6A2)

EAI:	106822454(SLC6A2)

MYB:	102260307(SLC6A2)

MYD:	102767742(SLC6A2)

MMYO:

118674190(SLC6A2)

MLF:

102418731

MDT:	132217564(SLC6A2)

MYUM:

138997400(SLC6A2)

PKL:	118720556(SLC6A2)

EFUS:

103295852(SLC6A2)

MNA:	107543468(SLC6A2)

DRO:	112296768(SLC6A2)

SHON:

119001198(SLC6A2) 119002131

AJM:	119046486(SLC6A2)

PDIC:

114488223(SLC6A2)

PHAS:

123805866(SLC6A2)

MMF:	118638723(SLC6A2)

PPAM:

129068134(SLC6A2)

HAI:	109395651(SLC6A2)

RFQ:	117034338(SLC6A2)

PALE:

102884060(SLC6A2)

PGIG:

120617386(SLC6A2)

PVP:	105292076(SLC6A2)

RAY:	107499665(SLC6A2)

MJV:	108387924(SLC6A2)

TOD:	119250354(SLC6A2)

SARA:

101540435(SLC6A2)

SFUM:

130044117(SLC6A2)

SETR:

126027093(SLC6A2)

LAV:	100674932(SLC6A2)

TMU:

101358293

ETF:	101654810(SLC6A2)

DNM:	101442734(SLC6A2)

MDO:	100020675(SLC6A2)

GAS:	123235294(SLC6A2)

SHR:	100923309(SLC6A2)

AFZ:

127550722

PCW:	110207505(SLC6A2)

TVP:	118843194(SLC6A2)

PBRV:

138157243(SLC6A2)

MLAO:

141494496(SLC6A2)

OAA:	100077203(SLC6A2)

TACU:

119934581(SLC6A2)

GGA:	395458(SLC6A2)

PCOC:

116243705(SLC6A2)

MGP:	100546763(SLC6A2)

CJO:	107319209(SLC6A2)

TPAI:

128081698(SLC6A2)

LMUT:

125699262(SLC6A2)

NMEL:

110404429(SLC6A2)

APLA:

101802443(SLC6A2)

AACU:

137861699(SLC6A2)

OJA:	118172914(SLC6A2)

ACYG:

106043077

CATA:

118246389(SLC6A2)

AFUL:

116494051(SLC6A2)

TGU:	100231425(SLC6A2)

LSR:	110484415(SLC6A2)

VMC:	128812763(SLC6A2)

SCAN:

103816633(SLC6A2)

PMOA:

120508059(SLC6A2)

OTC:	121333902(SLC6A2)

PRUF:

121348827(SLC6A2)

ATRC:

139596281(SLC6A2)

MATE:

118691364(SLC6A2)

GFR:	102037995(SLC6A2)

FAB:	101811397(SLC6A2)

OMA:	130257882(SLC6A2)

PHI:	102106504(SLC6A2)

PMAJ:

107210030(SLC6A2)

CCAE:

111934580(SLC6A2)

CCW:	104687553(SLC6A2)

CBRC:

103620305(SLC6A2)

ACOE:

138116906(SLC6A2)

ETL:	114060391(SLC6A2)

ZAB:	102064126(SLC6A2)

ZLE:	135452641(SLC6A2)

ACHL:

103810679(SLC6A2)

SVG:

106864229

MMEA:

130572731(SLC6A2)

HRT:	120757838(SLC6A2)

SATI:

136366632(SLC6A2)

CFAI:

136295674(SLC6A2)

CCIC:

134048112(SLC6A2)

FPG:	101911701(SLC6A2)

FCH:	102055675(SLC6A2)

CCRI:

104158664

NNT:	104407320(SLC6A2)

SHAB:

115601100(SLC6A2)

ACUN:

113484377(SLC6A2)

ANOC:

141963562(SLC6A2)

SURA:

141948853(SLC6A2)

TALA:

104358319(SLC6A2)

ACHC:

115346493(SLC6A2)

HALD:

104319338

HLE:	104842472(SLC6A2)

AGEN:

126040652

HHAR:

128146513(SLC6A2)

BBUT:

142036747(SLC6A2)

GCL:

127021031

CSTI:

104562814

LDI:

104351074

MNB:	103775657(SLC6A2)

DPUB:

104298997(SLC6A2)

PPUS:

135184542(SLC6A2)

AVIT:

104271570(SLC6A2)

BRHI:

104491388

EGZ:	104125184(SLC6A2)

NNI:	104016356(SLC6A2)

PCRI:

104028170(SLC6A2)

PARX:

142061084(SLC6A2)

PADL:

103914185(SLC6A2)

AFOR:

103896823(SLC6A2)

FGA:

104078393

CBOR:

142087008(SLC6A2)

GSTE:

104253335(SLC6A2)

CBOY:

140656574(SLC6A2)

MAME:

142413523(SLC6A2)

CLV:

102091262

CNIC:

135991888(SLC6A2)

MUI:

104538676

PGUU:

104461213

PLET:

104625783(SLC6A2)

EHS:

104506768

CMAC:

104476838

CUCA:

104056806(SLC6A2)

TEO:

104374093

BREG:

104634438

GAME:

129212416(SLC6A2)

OHA:	104333963(SLC6A2)

ACAR:

104528803

CPEA:

104388559(SLC6A2)

CVF:

104287754

RTD:	128909390(SLC6A2)

CRID:

134514430(SLC6A2)

LMIC:

141741933(SLC6A2)

NARQ:

141471332(SLC6A2)

AAM:	106483331(SLC6A2)

AROW:

112967557(SLC6A2)

NPD:	112947676(SLC6A2)

TGT:

104570884

DNE:

112984309

SCAM:

104146404(SLC6A2)

ASN:	102375768(SLC6A2)

AMJ:	106737066(SLC6A2)

CPOO:

109310502(SLC6A2)

GGN:	109289623(SLC6A2)

PSS:	102447172(SLC6A2)

CIZ:	142020523(SLC6A2)

CMY:	102931207(SLC6A2)

CCAY:

125620597(SLC6A2)

LKP:	140896205(SLC6A2)

NDS:	141996513(SLC6A2)

DCC:	119841325(SLC6A2)

CPIC:

101940091(SLC6A2)

TST:	117886731(SLC6A2)

EOB:	135888671(SLC6A2)

CABI:

116820819(SLC6A2)

MRV:	120384506(SLC6A2)

ACS:	100557960(slc6a2)

ASAO:

132783268(SLC6A2)

PVT:	110090099(SLC6A2)

SUND:

121914478(SLC6A2)

PBI:

103059752

PMUR:

107287657

CTIG:

120312101(SLC6A2)

PGUT:

117670959(SLC6A2)

PCAE:

139323761(SLC6A2)

APRI:

131184278(SLC6A2)

PTEX:

113444986(SLC6A2)

NSS:	113424568(SLC6A2)

VKO:	123022376(SLC6A2)

PMUA:

114602203(SLC6A2)

PRAF:

128419437(SLC6A2)

ZVI:	118086597(SLC6A2)

HCG:	128334627(SLC6A2)

GJA:

107122162

STOW:

125443761(SLC6A2)

EMC:	129343890(SLC6A2)

XLA:	108715347(slc6a2.S)

XTR:	100486589(slc6a2)

NPR:	108797886 108798466

RTEM:

120917450(SLC6A2)

ACAT:

141112326(SLC6A2)

PADS:

140338664(SLC6A2)

BBUF:

120980180(SLC6A2)

BGAR:

122920632(SLC6A2)

DTC:	141095589(SLC6A2)

HSQ:	130276646(SLC6A2)

PCOB:

134969366(SLC6A2)

PWL:	138267369(SLC6A2)

MUO:	115470783(SLC6A2)

GSH:	117360001(SLC6A2)

DRE:	565776(slc6a2)

SRX:	107713067 107755047

SANH:

107657091 107696692

SGH:	107548932 107563470

CCAR:

109058357 109105149

CAUA:

113051474 113106042

CGIB:

127961269 128016866

PTET:

122348318(slc6a2)

LROH:

127168525(slc6a2)

GRF:	141331150(slc6a2)

OMC:	131544548(slc6a2)

PPRM:

120491040(slc6a2)

RKG:	130099608(slc6a2)

MAMB:

125264832(slc6a2)

CIDE:

127516485

CERY:

137031353(slc6a2)

MASI:

127415964 127448402

TROS:

130560674(slc6a2)

TDW:	130419605(slc6a2)

MANU:

129444619(slc6a2) 141363515

PDAB:

135749221(slc6a2)

IPU:

108259314

IFU:	128602945(slc6a2)

PHYP:

113540907(slc6a2)

SMEO:

124379952(slc6a2)

TFD:	113636842(slc6a2)

TVC:	132838783(slc6a2)

CGAR:

128518613(slc6a2)

NGRA:

132875219(slc6a2)

TRN:	134303903(slc6a2)

AMEX:

125787312(slc6a2)

CMAO:

118817457(slc6a2)

EEE:

113590948

CHAR:

105899787(slc6a2)

SPIL:

134095179(slc6a2)

ASAD:

121681936(slc6a2)

TRU:	101067849(slc6a2)

TFS:	130519526(slc6a2)

LCO:	104926948(slc6a2)

NCC:

104949971

TBEN:

117496688(slc6a2)

CGOB:

115024602(slc6a2)

PGEO:

117443208(slc6a2)

GACU:

117549200(slc6a2)

EMAC:

134863487(slc6a2)

ELY:	117271635(slc6a2)

EFO:	125904021(slc6a2)

PLEP:

121966622(slc6a2)

SLUC:

116037546(slc6a2)

ECRA:

117941836(slc6a2)

ESP:	116690483(slc6a2)

PFLV:

114553263(slc6a2)

GAT:	120810173(slc6a2)

PPUG:

119226509(slc6a2)

AFB:	129099286(slc6a2)

CLUM:

117728672(slc6a2)

PSWI:

130193111(slc6a2)

CANA:

137805127(slc6a2)

CVE:	137887446(slc6a2)

MSAM:

119890372(slc6a2)

SCHU:

122878827(slc6a2)

EARM:

139287788(slc6a2)

CUD:	121514941(slc6a2)

SPUL:

138607743(slc6a2)

LMIX:

132974870(slc6a2)

HTC:	141787663(slc6a2)

ALAT:

119018809(slc6a2)

ASTR:

137614083(slc6a2)

PKLU:

139214494(slc6a2)

MZE:	101471905(slc6a2)

ONL:	100700329(slc6a2)

OAU:	116325636(slc6a2)

OLA:	101172721(slc6a2)

OML:	112160734(slc6a2)

CSAI:

133464022(slc6a2)

XMA:	102227470(slc6a2)

XCO:	114143628(slc6a2)

XHE:	116719073(slc6a2)

PRET:

103462670(slc6a2)

PFOR:

103138103(slc6a2)

PLAI:

106948462

PMEI:

106910972

GAF:	122819899(slc6a2)

PPRL:

129364148(slc6a2)

CVG:

107095643

CTUL:

119795144(slc6a2)

GMU:	124867375(slc6a2)

NFU:	107381258(slc6a2)

KMR:	108240271(slc6a2)

ALIM:

106517246(slc6a2)

NWH:	119426361(slc6a2)

AOCE:

111577722(slc6a2)

EJA:	138213208(slc6a2)

BFRE:

138616259(slc6a2)

MCEP:

125005810(slc6a2)

CSEM:

103378986

POV:	109625157(slc6a2)

SSEN:

122772766(slc6a2)

SSOE:

131459339(slc6a2)

HHIP:

117759238(slc6a2)

HSP:	118112270(slc6a2)

PPLT:

128444262(slc6a2)

SMAU:

118302734(slc6a2)

LCF:

108877063

SDU:	111218552(slc6a2)

SLAL:

111649515

XGL:	120794649(slc6a2)

HCQ:	109514028(slc6a2)

SSCV:

125967307(slc6a2)

SBIA:

133498145(slc6a2)

PEE:	133397683(slc6a2)

PTAO:

133474180(slc6a2)

BPEC:

110175264(slc6a2)

ENY:	140381003(slc6a2)

MALB:

109955887(slc6a2)

BSPL:

114852566(slc6a2)

SJO:	128376527(slc6a2)

SSCO:

134002662(slc6a2)

TTY:	137186070(slc6a2)

GMH:	115558961(slc6a2)

SASA:

106562417 106562421

STRU:

115167015 115203312

OTW:	112235785(slc6a2) 112236514

OMY:	110506750 110526616

OGO:	124033572 124035548

ONE:

115126128

OKI:	109878794 109880633

OKE:	118376015 118382143

OMM:	135551249 135557066

OCLA:

139384541 139411616

SALP:

112075721

SNH:	120025183 120039803

SFON:

129834587 129854477

CCLU:

121580364(slc6a2)

ELS:	105023460(slc6a2)

OEP:	134027872(slc6a2)

SFM:	108926194 108928306

PKI:	111832722(slc6a2) 111858176

AANG:

118214787 118227629

AROT:

135241535 135255087

CCOG:

133111944 133130486

LOC:	102687925(slc6a2)

PSPA:

121296716(slc6a2) 121326189

ARUT:

117424449 117425320

PSEX:

120535226(slc6a2)

LCM:	102350552(SLC6A2)

CMK:	103176104(slc6a2)

RTP:	109933884(slc6a2)

CPLA:

122558438(slc6a2)

CPUN:

140453044(slc6a2)

HOC:	132823965(slc6a2)

SCAU:

119971337(slc6a2)

LERI:

129705055(slc6a2)

HAKA:

140740633(slc6a2)

PMRN:

LRJ:

BFO:

BBEL:

SCLV:

SPU:

LPIC:

LVG:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

TCA:	661387 664252

TMOL:

138122622 138138687

DPA:	109534825 109546959

ESIM:

EFOR:

SOY:

RFG:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

BMOR:

BMAN:

MSEX:

DPL:	KGM_204532

BANY:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

LDA:

PHU:	Phum_PHUM228010

FOC:

TPAL:

ZNE:

CSEC:

PAME:

SGRE:

BROR:

IEL:

HAMR:

FCD:

PJA:	122242309 122248300

PCHN:

PMOO:

PTRU:

SPRM:

MNZ:

PORN:

HAZT:

OOT:

ISC:

DSV:

DALB:

135911055 135911057 139046740 139052724 139059306

RSAN:

RMP:

VDE:

VJA:

GOE:

DPTE:

DFR:

CSCU:

CVS:	136970469 136983947

PTEP:

107445150 107451050

ABRU:

129960508 129972627

UDV:	129218952 129220555

SDM:	118186983 118193103 118198446

LPOL:

106461534

HRO:	HELRODRAFT_166710

LGI:	LOTGIDRAFT_123645

PVUL:

LSAX:

BARL:

BGT:

HRF:	124116200 124140834 124140835

HRJ:	124259037 124259040 124269277 124278161

HASI:

137255720 137258313 137282536 137298888

HCRA:

139448701 139451410 139464350 139465163 139470164

CRG:

105320872

OED:	125651648 125661680

MYI:

110449896

PMAX:

117337676

AIRR:

138315673

YBA:	132557235 132557826

MCAF:

MMER:

RPHI:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_193800

SHX:	MS3_00002785(SLC6A3)

LLON:

135483661 135495927 135496004

MCAZ:

138042665

MFOO:

138007635

» show all

Reference

PMID:17067279

Authors

Hahn MK, Blakely RD

Title

The functional impact of SLC6 transporter genetic variation.

Journal

Annu Rev Pharmacol Toxicol 47:401-41 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105242

Reference

PMID:16916974

Authors

Thimgan MS, Berg JS, Stuart AE

Title

Comparative sequence analysis and tissue localization of members of the SLC6 family of transporters in adult Drosophila melanogaster.

Journal

J Exp Biol 209:3383-404 (2006)
DOI:10.1242/jeb.02328

Reference

PMID:11343649

Authors

Torres GE, Yao WD, Mohn AR, Quan H, Kim KM, Levey AI, Staudinger J, Caron MG

Title

Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1.

Journal

Neuron 30:121-34 (2001)
DOI:10.1016/S0896-6273(01)00267-7

Sequence

[hsa:6530]

LinkDB

DBGET integrated database retrieval system