KEGG   DRUG: Pantoprazole sodium
Entry
D02593                      Drug                                   

Name
Pantoprazole sodium (USP);
Pantoprazole sodium hydrate (JAN);
Protonix (TN)
Product
  Generic
PANTOPRAZOLE SODIUM (A-S Medication Solutions), PANTOPRAZOLE SODIUM (A-S Medication Solutions), PANTOPRAZOLE SODIUM (Amneal Pharmaceuticals LLC), PANTOPRAZOLE SODIUM (Bryant Ranch Prepack), PANTOPRAZOLE SODIUM (Bryant Ranch Prepack), PANTOPRAZOLE SODIUM (Camber Pharmaceuticals), PANTOPRAZOLE SODIUM (DIRECT RX), PANTOPRAZOLE (Dr.Reddy's Laboratories Limited), PANTOPRAZOLE SODIUM (Medsource Pharmaceuticals), PANTOPRAZOLE SODIUM (NuCare Pharmaceuticals), PANTOPRAZOLE SODIUM (NuCare Pharmaceuticals), PANTOPRAZOLE SODIUM (NuCare Pharmaceuticals), PANTOPRAZOLE SODIUM (Preferred Pharmaceuticals), PANTOPRAZOLE SODIUM (Proficient Rx LP), PANTOPRAZOLE SODIUM (Proficient Rx LP), PANTOPRAZOLE SODIUM (Proficient Rx LP), PANTOPRAZOLE SODIUM (Proficient Rx LP), PANTOPRAZOLE SODIUM (QPharma), PANTOPRAZOLE SODIUM (Quality Care Products), PANTOPRAZOLE SODIUM (Quality Care Products), PANTOPRAZOLE SODIUM (REMEDYREPACK), PANTOPRAZOLE SODIUM (REMEDYREPACK), PANTOPRAZOLE SODIUM (St. Mary's Medical Park Pharmacy), PANTOPRAZOLE SODIUM (Unit Dose Services), PANTOPRAZOLE SODIUM (medsource pharmaceuticals), PROTONIX (Advanced Rx Pharmacy of Tennessee), PROTONIX (Advanced Rx Pharmacy of Tennessee), PROTONIX (Advanced Rx Pharmacy of Tennessee), PANTOPRAZOLE SODIUM (A-S Medication Solutions), PANTOPRAZOLE SODIUM (A-S Medication Solutions), PANTOPRAZOLE SODIUM (A-S Medication Solutions), PANTOPRAZOLE SODIUM (A-S Medication Solutions), PANTOPRAZOLE SODIUM (A-S Medication Solutions), PANTOPRAZOLE SODIUM (A-S Medication Solutions), PANTOPRAZOLE SODIUM (A-S Medication Solutions), PANTOPRAZOLE SODIUM (American Health Packaging), PANTOPRAZOLE SODIUM (American Health Packaging), PANTOPRAZOLE SODIUM (Aphena Pharma Solutions - Tennessee), PANTOPRAZOLE SODIUM (Aphena Pharma Solutions - Tennessee), PANTOPRAZOLE SODIUM (Aphena Pharma Solutions - Tennessee), PANTOPRAZOLE SODIUM (Aphena Pharma Solutions - Tennessee), PANTOPRAZOLE SODIUM (Aphena Pharma Solutions - Tennessee), PANTOPRAZOLE SODIUM (Aphena Pharma Solutions - Tennessee), PANTOPRAZOLE SODIUM (Aphena Pharma Solutions - Tennessee), PANTOPRAZOLE SODIUM (Aphena Pharma Solutions - Tennessee), PANTOPRAZOLE SODIUM (Aphena Pharma Solutions - Tennessee), PANTOPRAZOLE SODIUM (AuroMedics Pharma LLC), PANTOPRAZOLE SODIUM (Aurobindo Pharma Limited), PANTOPRAZOLE SODIUM (AvKARE), PANTOPRAZOLE SODIUM (AvPAK), PANTOPRAZOLE SODIUM (AvPAK), PANTOPRAZOLE SODIUM (Bryant Ranch Prepack), PANTOPRAZOLE SODIUM (Bryant Ranch Prepack), PANTOPRAZOLE SODIUM (Bryant Ranch Prepack), PANTOPRAZOLE SODIUM (Bryant Ranch Prepack), PANTOPRAZOLE SODIUM (Bryant Ranch Prepack), PANTOPRAZOLE SODIUM (Bryant Ranch Prepack), PANTOPRAZOLE SODIUM (Bryant Ranch Prepack), PANTOPRAZOLE SODIUM (Burel Pharmaceuticals), PANTOPRAZOLE SODIUM (Cardinal Health), PANTOPRAZOLE SODIUM (Cardinal Health), PANTOPRAZOLE SODIUM (Cardinal Health), PANTOPRAZOLE SODIUM (Cardinal Health), PANTOPRAZOLE SODIUM (Cardinal Health), PANTOPRAZOLE SODIUM (Civica), PANTOPRAZOLE SODIUM (Clinical Solutions Wholesale), PANTOPRAZOLE SODIUM (Contract Pharmacy Services-PA), PANTOPRAZOLE SODIUM (Contract Pharmacy Services-PA), PANTOPRAZOLE SODIUM (DIRECT RX), PANTOPRAZOLE SODIUM (DIRECT RX), PANTOPRAZOLE SODIUM (DOH CENTRAL PHARMACY), PANTOPRAZOLE SODIUM (Denton Pharma), PANTOPRAZOLE SODIUM (Denton Pharma), PANTOPRAZOLE SODIUM (Denton Pharma), PANTOPRAZOLE SODIUM (Denton Pharma), PANTOPRAZOLE SODIUM (Denton Pharma), PANTOPRAZOLE SODIUM (Fresenius Kabi USA), PANTOPRAZOLE SODIUM (Golden State Medical Supply), PANTOPRAZOLE SODIUM (Golden State Medical Supply), PANTOPRAZOLE SODIUM (Ingenus Pharmaceuticals), PANTOPRAZOLE SODIUM (Jubilant Cadista Pharmaceuticals), PANTOPRAZOLE SODIUM (Lake Erie Medical DBA Quality Care Products LLC), PANTOPRAZOLE SODIUM (Lannett Company), PANTOPRAZOLE SODIUM (Legacy Pharmaceutical Packaging), PANTOPRAZOLE SODIUM (Legacy Pharmaceutical Packaging), PANTOPRAZOLE SODIUM (Major Pharmaceuticals), PANTOPRAZOLE SODIUM (Major Pharmaceuticals), PANTOPRAZOLE SODIUM (McKesson Corporation dba SKY Packaging), PANTOPRAZOLE SODIUM (Medsource Pharmaceuticals), PANTOPRAZOLE SODIUM (Mylan Institutional), PANTOPRAZOLE SODIUM (Mylan Pharmaceuticals), PANTOPRAZOLE SODIUM (NCS HealthCare of KY), PANTOPRAZOLE SODIUM (NCS HealthCare of KY), PANTOPRAZOLE SODIUM (NuCare Pharmaceuticals), PANTOPRAZOLE SODIUM (NuCare Pharmaceuticals), PANTOPRAZOLE SODIUM (NuCare Pharmaceuticals), PANTOPRAZOLE SODIUM (NuCare Pharmaceuticals), PANTOPRAZOLE SODIUM (NuCare Pharmaceuticals), PANTOPRAZOLE SODIUM (NuCare Pharmaceuticals), PANTOPRAZOLE SODIUM (NuCare Pharmaceuticals), PANTOPRAZOLE SODIUM (NuCare Pharmaceuticals), PANTOPRAZOLE SODIUM (NuCare Pharmaceuticals), PANTOPRAZOLE SODIUM (NuCare Pharmaceuticals), PANTOPRAZOLE SODIUM (NuCare Pharmaceuticals), PANTOPRAZOLE SODIUM (PD-Rx Pharmaceuticals), PANTOPRAZOLE SODIUM (PD-Rx Pharmaceuticals), PANTOPRAZOLE SODIUM (Prasco Laboratories), PANTOPRAZOLE SODIUM (Preferred Pharmaceuticals), PANTOPRAZOLE SODIUM (Preferred Pharmaceuticals), PANTOPRAZOLE SODIUM (Proficient Rx LP), PANTOPRAZOLE SODIUM (Proficient Rx LP), PANTOPRAZOLE SODIUM (REMEDYREPACK), PANTOPRAZOLE SODIUM (REMEDYREPACK), PANTOPRAZOLE SODIUM (REMEDYREPACK), PANTOPRAZOLE SODIUM (REMEDYREPACK), PANTOPRAZOLE SODIUM (REMEDYREPACK), PANTOPRAZOLE SODIUM (REMEDYREPACK), PANTOPRAZOLE SODIUM (REMEDYREPACK), PANTOPRAZOLE SODIUM (RPK Pharmaceuticals), PANTOPRAZOLE SODIUM (RedPharm Drug), PANTOPRAZOLE SODIUM (RedPharm Drug), PANTOPRAZOLE SODIUM (Sandoz), PANTOPRAZOLE SODIUM (St. Mary's Medical Park Pharmacy), PANTOPRAZOLE SODIUM (St. Mary's Medical Park Pharmacy), PANTOPRAZOLE SODIUM (Sun Pharmaceutical Industries), PANTOPRAZOLE SODIUM (Sun Pharmaceutical Industries), PANTOPRAZOLE SODIUM (Torrent Pharmaceuticals Limited), PANTOPRAZOLE SODIUM (Wockhardt USA LLC.), PANTOPRAZOLE SODIUM (medsource pharmaceuticals), PANTOPRAZOLE SODIUM D/R (DIRECT RX), PANTOPRAZOLE SODIUM D/R (Direct_Rx), PANTOPRAZOLE SODIUM D/R (Direct_Rx)
Formula
(C16H14F2N3O4S. Na)2. 3H2O
Exact mass
864.1458
Mol weight
864.7491
Structure
Class
Gastrointestinal agent
 DG01975  Agents for peptic ulcer
  DG01646  Proton pump inhibitor (PPI)
Metabolizing enzyme substrate
 DG01639  CYP2C19 substrate
Remark
ATC code: A02BC02
Chemical structure group: DG00021
Product (DG00021): D02593<US>
Efficacy
Anti-ulcerative, Proton pump inhibitor
  Disease
Gastroesophageal reflux disease [DS:H01602]
Zollinger-Ellison syndrome [DS:H01522]
Comment
Benzimidazole derivative
Target
ATP4 [HSA:495 496] [KO:K01542 K01543]
  Pathway
hsa04966  Collecting duct acid secretion
hsa04971  Gastric acid secretion
Metabolism
Enzyme: CYP2C19 [HSA:1557]; CYP3A4 [HSA:1576]
Interaction
Structure map
map07038  Antiulcer drugs
map07233  Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BC Proton pump inhibitors
     A02BC02 Pantoprazole
      D02593  Pantoprazole sodium (USP) <US>
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Proton Pump Inhibitors
   Pantoprazole
    D02593  Pantoprazole sodium (USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   ATPase
    ATP4
     D02593  Pantoprazole sodium (USP) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D02593
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D02593
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02593
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02593
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D02593
Other DBs
CAS: 164579-32-2
PubChem: 17396764
DrugBank: DB00213
LigandBox: D02593
LinkDB
KCF data

ATOM        57
            1   O0  O    31.5571  -29.4634
            2   Z   Na   18.5500  -23.1700 #+
            3   C8x C    13.5100  -24.5700
            4   C8y C    13.5100  -25.9700
            5   C8x C    14.7000  -26.6700
            6   C8y C    15.8900  -25.9700
            7   C8y C    15.8900  -24.5700
            8   C8x C    14.7000  -23.8700
            9   N5x N    17.2900  -26.3900
            10  C8y C    18.0600  -25.2700
            11  N4x N    17.2900  -24.1500 #-
            12  S4a S    19.4600  -25.2700
            13  C1b C    20.1600  -26.5300
            14  O3c O    20.1600  -24.0800
            15  O2a O    12.2500  -26.6700
            16  C1c C    11.0600  -25.9700
            17  X   F     9.8700  -26.6700
            18  X   F    11.0600  -24.5700
            19  C8y C    21.5600  -26.5300
            20  C8y C    22.2600  -27.7200
            21  C8y C    23.6600  -27.7200
            22  C8x C    24.3600  -26.4600
            23  C8x C    23.6600  -25.2700
            24  N5x N    22.2600  -25.2700
            25  O2a O    21.5600  -28.9100
            26  C1a C    20.1600  -28.9100
            27  O2a O    24.3600  -28.9100
            28  C1a C    25.7600  -28.9100
            29  O0  O    31.5571  -29.4634
            30  O0  O    31.5571  -29.4634
            31  Z   Na   18.5500  -23.1700 #+
            32  C8x C    13.5100  -24.5700
            33  C8y C    13.5100  -25.9700
            34  C8x C    14.7000  -26.6700
            35  C8y C    15.8900  -25.9700
            36  C8y C    15.8900  -24.5700
            37  C8x C    14.7000  -23.8700
            38  N4x N    17.2900  -24.1500 #-
            39  C8y C    18.0600  -25.2700
            40  N5x N    17.2900  -26.3900
            41  S4a S    19.4600  -25.2700
            42  C1b C    20.1600  -26.5300
            43  C8y C    21.5600  -26.5300
            44  C8y C    22.2600  -27.7200
            45  C8y C    23.6600  -27.7200
            46  C8x C    24.3600  -26.4600
            47  C8x C    23.6600  -25.2700
            48  N5x N    22.2600  -25.2700
            49  O2a O    24.3600  -28.9100
            50  C1a C    25.7600  -28.9100
            51  O2a O    21.5600  -28.9100
            52  C1a C    20.1600  -28.9100
            53  O3c O    20.1600  -24.0800
            54  O2a O    12.2500  -26.6700
            55  C1c C    11.0600  -25.9700
            56  X   F     9.8700  -26.6700
            57  X   F    11.0600  -24.5700
BOND        56
            1     3   4 2
            2     4   5 1
            3     5   6 2
            4     6   7 1
            5     7   8 2
            6     3   8 1
            7     6   9 1
            8     9  10 2
            9    10  11 1
            10    7  11 1
            11   10  12 1
            12   12  13 1
            13   12  14 2
            14    4  15 1
            15   15  16 1
            16   16  17 1
            17   16  18 1
            18   13  19 1
            19   19  20 2
            20   20  21 1
            21   21  22 2
            22   22  23 1
            23   23  24 2
            24   19  24 1
            25   20  25 1
            26   25  26 1
            27   21  27 1
            28   27  28 1
            29   32  33 2
            30   33  34 1
            31   34  35 2
            32   35  36 1
            33   36  37 2
            34   32  37 1
            35   35  40 1
            36   40  39 2
            37   39  38 1
            38   36  38 1
            39   39  41 1
            40   41  42 1
            41   41  53 2
            42   33  54 1
            43   54  55 1
            44   55  56 1
            45   55  57 1
            46   42  43 1
            47   43  44 2
            48   44  45 1
            49   45  46 2
            50   46  47 1
            51   47  48 2
            52   43  48 1
            53   44  51 1
            54   51  52 1
            55   45  49 1
            56   49  50 1
BRACKET     1    29.4000  -29.9600   29.4000  -28.7000
            1    32.2000  -28.7000   32.2000  -29.9600
            1  3
 ORIGINAL  1    1
 REPEAT    1   29  30
            2     9.1700  -29.9600    9.1700  -22.2600
            2    27.5800  -22.2600   27.5800  -29.9600
            2  2
 ORIGINAL  2    2   3   4   5   6   7   8  11  10   9  12  13  19  20  21  22
            2   23  24  27  28  25  26  14  15  16  17  18
 REPEAT    2   31  32  33  34  35  36  37  38  39  40  41  42  43  44  45  46
            2   47  48  49  50  51  52  53  54  55  56  57

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