KEGG   DRUG: Pipotiazine palmitate
Entry
D02680                      Drug                                   
Name
Pipotiazine palmitate (USAN);
Piportil depot (TN)
Formula
C40H63N3O4S2
Exact mass
713.426
Mol weight
714.0759
Structure
Class
Neuropsychiatric agent
 DG03200  Antipsychotic agent
  DG01905  Phenothiazine antipsychotics
Remark
ATC code: N05AC04
Chemical structure group: DG00884
Efficacy
Antipsychotic
Comment
Phenothiazine derivative
Target
DRD2 [HSA:1813] [KO:K04145]
DRD1 [HSA:1812] [KO:K04144]
HTR2A [HSA:3356] [KO:K04157]
HTR1A [HSA:3350] [KO:K04153]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AC Phenothiazines with piperidine structure
     N05AC04 Pipotiazine
      D02680  Pipotiazine palmitate (USAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG00884  Pipotiazine
     D02680  Pipotiazine palmitate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD1
     D02680  Pipotiazine palmitate (USAN)
    DRD2
     D02680  Pipotiazine palmitate (USAN)
   Serotonin
    HTR1A
     D02680  Pipotiazine palmitate (USAN)
    HTR2A
     D02680  Pipotiazine palmitate (USAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG00884  Pipotiazine
Other DBs
CAS: 37517-26-3
PubChem: 17396849
LigandBox: D02680
NIKKAJI: J261.190B
LinkDB
KCF data

ATOM        49
            1   C8x C    23.8870  -23.0370
            2   C8x C    25.0436  -22.3708
            3   C8y C    25.0436  -21.0316
            4   C8x C    23.8870  -20.3588
            5   C8y C    22.7236  -22.3708
            6   C8y C    22.7236  -21.0316
            7   N1y N    21.5630  -20.3588
            8   S2x S    21.5630  -23.0370
            9   C8y C    20.4022  -22.3708
            10  C8y C    20.4027  -21.0316
            11  C8x C    19.2424  -20.3584
            12  C8x C    18.0815  -21.0309
            13  C8x C    18.0811  -22.3701
            14  C8x C    19.2416  -23.0366
            15  C1b C    21.5595  -19.0264
            16  C1b C    22.7168  -18.3601
            17  C1b C    22.7168  -17.0277
            18  N1y N    23.8742  -16.3547
            19  C1x C    25.0334  -17.0250
            20  C1x C    26.1841  -16.3520
            21  C1y C    26.1825  -15.0155
            22  C1x C    25.0302  -14.3521
            23  C1x C    23.8726  -15.0183
            24  C1b C    27.3398  -14.3493
            25  C1b C    28.4973  -15.0089
            26  O7a O    29.6549  -14.3427
            27  C7a C    30.8122  -15.0021
            28  O6a O    30.8150  -16.3413
            29  S4a S    26.2048  -20.3596
            30  N1c N    27.3581  -21.0333
            31  C1a C    28.5193  -20.3613
            32  C1a C    27.3571  -22.3726
            33  O3c O    27.1447  -19.4099
            34  O3c O    25.2471  -19.4099
            35  C1b C    32.0222  -14.2972
            36  C1b C    33.2057  -14.9744
            37  C1b C    34.3937  -14.2821
            38  C1b C    35.5900  -14.9667
            39  C1b C    36.7715  -14.2783
            40  C1b C    37.9711  -14.9648
            41  C1b C    39.1510  -14.2775
            42  C1b C    40.3513  -14.9645
            43  C1b C    41.5309  -14.2774
            44  C1b C    42.7313  -14.9645
            45  C1b C    43.9110  -14.2775
            46  C1b C    45.1112  -14.9646
            47  C1b C    46.2911  -14.2776
            48  C1b C    47.4911  -14.9648
            49  C1a C    48.6712  -14.2778
BOND        52
            1    23  18 1
            2     1   2 2
            3    21  24 1
            4     2   3 1
            5    24  25 1
            6     9  10 2
            7    25  26 1
            8    10  11 1
            9    26  27 1
            10   11  12 2
            11   12  13 1
            12   13  14 2
            13   27  28 2
            14   14   9 1
            15    3  29 1
            16    5   6 2
            17   29  30 1
            18    7  15 1
            19   30  31 1
            20    6   7 1
            21   30  32 1
            22   15  16 1
            23   29  33 2
            24    7  10 1
            25   29  34 2
            26   16  17 1
            27    9   8 1
            28   17  18 1
            29    8   5 1
            30    3   4 2
            31    4   6 1
            32    5   1 1
            33   18  19 1
            34   19  20 1
            35   20  21 1
            36   21  22 1
            37   22  23 1
            38   27  35 1
            39   35  36 1
            40   36  37 1
            41   37  38 1
            42   38  39 1
            43   39  40 1
            44   40  41 1
            45   41  42 1
            46   42  43 1
            47   43  44 1
            48   44  45 1
            49   45  46 1
            50   46  47 1
            51   47  48 1
            52   48  49 1

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