| Entry |
|
|---|
| Name |
Peginterferon alfa-2a (USAN/INN);
Peginterferon alfa-2a (genetical recombination) (JAN);
Pegasys (TN) |
|---|
| Product |
|
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| Formula |
C10H17N2O5R(C2H4O)n(C2H4O)n
|
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| Structure |
|
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| Sequence |
CDLPQTHSLG SRRTLMLLAQ MRKISLFSCL KDRHDFGFPQ EEFGNQFQKA ETIPVLHEMI
QQIFNLFSTK DSSAAWDETL LDKFYTELYQ QLNDLEACVI QGVGVTETPL MKEDSILAVR
KYFQRITLYL KEKKYSPCAW EVVRAEIMRS FSLSTNLQES LRSKE
(Disulfide bridge: 1-98, 29-138; Pegylation site: 31, 121, 131, 134) |
|---|
| Type |
Peptide |
|---|
| Class |
Immunological agent
DG01752 Interferone
|
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| Remark |
| Therapeutic category: | 6399 |
|
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| Efficacy |
Antiviral, Biological response modifier |
|---|
| Disease |
Chronic hepatitis C [DS: H00413] Chronic hepatitis B [DS: H00412] |
|---|
| Comment |
R: Interferon alfa-2a [DR: D00745]
Treatment of hepatitis C
|
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| Target |
|
|---|
| Pathway |
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa04620 | Toll-like receptor signaling pathway |
| hsa04650 | Natural killer cell mediated cytotoxicity |
|
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| Interaction |
|
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| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L03 IMMUNOSTIMULANTS
L03A IMMUNOSTIMULANTS
L03AB Interferons
L03AB11 Peginterferon alfa-2a
D02747 Peginterferon alfa-2a (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
Immunological Agents
Immunostimulants
Interferons
Peginterferon Alfa 2a
D02747 Peginterferon alfa-2a (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
63 Biological preparations
639 Miscellaneous
6399 Others
D02747 Peginterferon alfa-2a (USAN/INN); Peginterferon alfa-2a (genetical recombination) (JAN)
Drug groups [BR:br08330]
Immunological agent
DG01752 Interferone
D02747 Peginterferon alfa-2a
Drug classes [BR:br08332]
Immunological agent
DG01752 Interferone
D02747 Peginterferon alfa-2a
Target-based classification of drugs [BR:br08310]
Cytokines and receptors
Cytokine receptors
Interferon receptors
IFNAR1
D02747 Peginterferon alfa-2a (USAN/INN) <JP/US>
IFNAR2
D02747 Peginterferon alfa-2a (USAN/INN) <JP/US>
Antimicrobials [BR:br08307]
Antivirals
Entry, fusion or uncoating inhibitor
Interferon
D02747 Peginterferon alfa-2a (USAN/INN) <JP/US>
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D02747
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D02747
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 24
1 O2a O 20.5100 -27.6500
2 C1b C 21.7224 -28.3500
3 C1b C 22.9349 -27.6500
4 O7a O 24.1473 -28.3500
5 C7a C 25.3597 -27.6500
6 N1b N 26.5722 -28.3500
7 C1c C 27.7846 -27.6500
8 C5a C 28.9970 -28.3500
9 R R 30.2095 -27.6500
10 O5a O 28.9970 -29.7499
11 C1b C 27.7846 -26.2500
12 O6a O 25.3597 -26.2501
13 C1b C 26.5762 -25.5523
14 C1b C 26.5762 -24.1523
15 C1b C 25.3807 -23.4620
16 N1b N 24.1954 -24.1463
17 C7a C 23.0031 -23.4577
18 O7a O 21.8142 -24.1441
19 C1b C 20.6238 -23.4566
20 C1b C 19.4339 -24.1436
21 O6a O 23.0031 -22.0503
22 O2a O 18.2439 -23.4563
23 C1a C 19.2976 -28.3500
24 C1a C 17.0537 -24.1433
BOND 23
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 6 7 1
7 7 8 1
8 8 9 1
9 8 10 2
10 7 11 1 #Up
11 5 12 2
12 11 13 1
13 13 14 1
14 14 15 1
15 15 16 1
16 16 17 1
17 17 18 1
18 18 19 1
19 19 20 1
20 17 21 2
21 20 22 1
22 1 23 1
23 22 24 1
BRACKET 1 17.9200 -25.1300 17.9200 -23.0300
1 20.7900 -23.0300 20.7900 -25.1300
1 n
ORIGINAL 1 19 20 22
REPEAT 1
2 20.1600 -29.3300 20.1600 -27.2300
2 23.1000 -27.2300 23.1000 -29.3300
2 n
ORIGINAL 2 1 2 3
REPEAT 2
|
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