KEGG   DRUG: Acitretin
Entry
D02754                      Drug                                   
Name
Acitretin (USP/INN);
Soriatane (TN)
Product
  Generic
ACITRETIN (Alembic Pharmaceuticals Limited), ACITRETIN (Alembic Pharmaceuticals), ACITRETIN (Amneal Pharmaceuticals of New York LLC), ACITRETIN (AvKARE), ACITRETIN (Bryant Ranch Prepack), ACITRETIN (Bryant Ranch Prepack), ACITRETIN (Bryant Ranch Prepack), ACITRETIN (Mylan Pharmaceuticals), ACITRETIN (Sigmapharm Laboratories), ACITRETIN (Teva Pharmaceuticals USA)
Formula
C21H26O3
Exact mass
326.1882
Mol weight
326.43
Structure
Simcomp
Class
Vitamin and mineral
 DG01604  Retinol derivative
Remark
ATC code: D05BB02
Product: D02754<US>
Efficacy
Antipsoriatic, Retinoic acid receptor agonist
  Disease
Psoriasis [DS:H01656]
Comment
Vitamin A derivative
Target
NR1B (RAR) [HSA:5914 5915 5916] [KO:K08527 K08528 K08529]
NR2B (RXR) [HSA:6256 6257 6258] [KO:K08524 K08525 K08526]
  Pathway
hsa04659  Th17 cell differentiation
Structure map
map07223  Retinoic acid receptor (RAR) and retinoid X receptor (RXR) agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D05 ANTIPSORIATICS
   D05B ANTIPSORIATICS FOR SYSTEMIC USE
    D05BB Retinoids for treatment of psoriasis
     D05BB02 Acitretin
      D02754  Acitretin (USP/INN) <US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Acne and Rosacea Agents
   Retinoids
    Acitretin
     D02754  Acitretin (USP/INN)
Drug groups [BR:br08330]
 Vitamin and mineral
  DG01604  Retinol derivative
   D02754  Acitretin
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Retinoic acid receptor (RAR)
    NR1B (RAR)
     D02754  Acitretin (USP/INN) <US>
  Hepatocyte nuclear factor 4 like receptors
   Retinoid X receptor (RXR)
    NR2B (RXR)
     D02754  Acitretin (USP/INN) <US>
Other DBs
CAS: 55079-83-9
PubChem: 17396912
ChEBI: 50173
LigandBox: D02754
NIKKAJI: J23.289K
LinkDB
KCF data

ATOM        24
            1   C8y C    21.1622  -16.4882
            2   C8y C    21.1622  -17.8979
            3   C8y C    19.9639  -15.7834
            4   C2b C    22.4309  -15.7834
            5   C8x C    19.9639  -18.6028
            6   C8y C    18.7657  -16.4882
            7   C1a C    19.9639  -14.3736
            8   C2b C    23.6292  -16.4882
            9   C8y C    18.7657  -17.8979
            10  C2c C    24.8274  -15.7834
            11  C2b C    26.0257  -16.4882
            12  C1a C    24.8274  -14.3736
            13  C2b C    27.2239  -15.7834
            14  C2b C    28.4222  -16.4882
            15  C2c C    29.6204  -15.7834
            16  C2b C    30.8187  -16.4177
            17  C1a C    29.6204  -14.3736
            18  C6a C    32.0169  -15.7834
            19  O6a O    33.2857  -16.4177
            20  O6a O    32.0169  -14.3736
            21  C1a C    17.5392  -15.7933
            22  O2a O    17.5449  -18.6028
            23  C1a C    22.4057  -18.6028
            24  C1a C    16.3183  -17.9079
BOND        24
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     5   9 1
            9     8  10 1
            10   10  11 2
            11   10  12 1
            12   11  13 1
            13   13  14 2
            14   14  15 1
            15   15  16 2
            16   15  17 1
            17   16  18 1
            18   18  19 1
            19   18  20 2
            20    6   9 2
            21    6  21 1
            22    9  22 1
            23   23   2 1
            24   24  22 1

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