KEGG   DRUG: ActisomideHelp
Entry
D02762                      Drug                                   

Name
Actisomide (USAN/INN)
Formula
C23H35N3O
Exact mass
369.278
Mol weight
369.5435
Structure
Mol fileKCF fileDB search
Efficacy
Antiarrhythmic, Cardiac depressant, Sodium channel blocker
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Brite
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D02762  Actisomide (USAN/INN)
    SCN2A
     D02762  Actisomide (USAN/INN)
    SCN3A
     D02762  Actisomide (USAN/INN)
    SCN4A
     D02762  Actisomide (USAN/INN)
    SCN5A
     D02762  Actisomide (USAN/INN)
    SCN8A
     D02762  Actisomide (USAN/INN)
    SCN9A
     D02762  Actisomide (USAN/INN)
    SCN10A
     D02762  Actisomide (USAN/INN)
    SCN11A
     D02762  Actisomide (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 96914-39-5
PubChem: 17396920
LigandBox: D02762
NIKKAJI: J540.519J
LinkDB All DBs
KCF data Show

ATOM        27
            1   C1x C    31.8264  -19.2608
            2   C1x C    30.6802  -18.5866
            3   C1y C    29.4665  -19.2608
            4   N1y N    29.4665  -20.6093
            5   C1x C    30.6802  -21.2836
            6   C1x C    31.8264  -20.6093
            7   C1z C    28.3204  -18.5866
            8   C5x C    27.1742  -19.2608
            9   N2x N    27.1742  -20.6093
            10  C2y C    28.3204  -21.2836
            11  C1a C    28.3204  -22.6321
            12  O5x O    26.0279  -18.5866
            13  C8y C    28.3210  -17.2203
            14  C8x C    29.5555  -16.5081
            15  C8x C    29.5560  -15.1081
            16  C8x C    28.3438  -14.4077
            17  C8x C    27.1093  -15.1199
            18  C8x C    27.1088  -16.5199
            19  C1b C    25.9879  -16.9766
            20  C1b C    24.7574  -17.7097
            21  N1c N    23.5529  -17.0360
            22  C1c C    22.3380  -17.7602
            23  C1a C    21.1184  -17.0785
            24  C1a C    22.3578  -19.1797
            25  C1c C    23.5339  -15.6101
            26  C1a C    22.3017  -14.9203
            27  C1a C    24.7266  -14.9001
BOND        29
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     3   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 2
            11    4  10 1
            12   10  11 1
            13    8  12 2
            14    7  13 1 #Down
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   13  18 1
            21    7  19 1 #Up
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   22  24 1
            27   21  25 1
            28   25  26 1
            29   25  27 1

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