| Entry |
|
|---|
| Name |
Fosamprenavir calcium hydrate (JAN);
Lexiva (TN) |
|---|
| Formula |
C25H34N3O9PS. Ca. xH2O
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antiviral
DG03107 Anti-HIV agent
DG01647 HIV protease inhibitor
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
|
|---|
| Remark |
| Therapeutic category: | 6250 |
| Product (DG00656): | D03835<US> |
|
|---|
| Efficacy |
Antiviral, HIV protease inhibitor |
|---|
| Comment |
Active form of prodrug: Amprenavir [DR: D00894]
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
CYP inhibition: CYP3A4 [HSA: 1576]
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J05 ANTIVIRALS FOR SYSTEMIC USE
J05A DIRECT ACTING ANTIVIRALS
J05AE Protease inhibitors
J05AE07 Fosamprenavir
D02867 Fosamprenavir calcium hydrate (JAN)
USP drug classification [BR:br08302]
Antivirals
Anti-HIV Agents, Protease Inhibitors (PI)
Fosamprenavir
D02867 Fosamprenavir calcium hydrate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
62 Chemotherapeutics
625 Antivirals
6250 Antivirals
D02867 Fosamprenavir calcium hydrate (JAN)
Drug groups [BR:br08330]
Antiviral
DG03107 Anti-HIV agent
DG01647 HIV protease inhibitor
DG00656 Fosamprenavir
D02867 Fosamprenavir calcium hydrate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00656 Fosamprenavir
D02867 Fosamprenavir calcium hydrate
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00656 Fosamprenavir
D02867 Fosamprenavir calcium hydrate
Drug classes [BR:br08332]
Antiviral
DG03107 Anti-HIV agent
D02867 Fosamprenavir calcium hydrate
Antimicrobials [BR:br08307]
Antivirals
Polyprotein cleavage inhibitor
HIV protease inhibitor
D02867 Fosamprenavir calcium hydrate (JAN)
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D02867
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02867
Drug groups [BR:br08330]
Antiviral
DG03107 Anti-HIV agent
DG01647 HIV protease inhibitor
DG00656 Fosamprenavir
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00656 Fosamprenavir
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00656 Fosamprenavir
Antimicrobials abbreviations [BR:br08327]
Antivirals
Polyprotein cleavage inhibitor
HIV protease inhibitor
DG00656 Fosamprenavir
Prodrugs [br08324.html]
DG00656
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 41
1 O0 O 23.4177 -18.9171
2 Z Ca 7.9800 -25.9700 #2+
3 N1c N 16.1000 -22.0500
4 C1b C 14.9800 -21.3500
5 S4a S 17.6400 -21.3500
6 C1c C 13.7900 -22.0500
7 C8y C 19.0400 -22.0500
8 C1c C 12.6000 -21.3500
9 N1b N 11.4800 -22.0500
10 C7a C 10.2900 -21.3500
11 O7a O 9.1000 -22.0500
12 O6a O 10.2900 -20.0200
13 C1y C 7.9100 -21.4200
14 C8x C 19.0400 -23.4500
15 C8x C 20.2300 -24.0800
16 C8y C 21.3500 -23.4500
17 C8x C 21.3500 -22.0500
18 C8x C 20.2300 -21.3500
19 N1a N 22.6100 -24.1500
20 O2b O 13.7900 -24.0800
21 P1b P 12.6000 -24.8500
22 O1c O 11.0600 -25.6200 #-
23 O3c O 16.6600 -20.4400
24 O3c O 18.5500 -20.4400
25 O1c O 13.3000 -26.0400 #-
26 O1c O 11.9000 -23.6600
27 C1x C 7.9100 -20.0900
28 C1x C 6.6500 -21.8400
29 C1x C 5.8100 -20.7900
30 O2x O 6.6500 -19.6700
31 C1b C 16.1000 -23.4500
32 C1c C 17.2900 -24.2200
33 C1a C 18.5500 -23.5200
34 C1a C 17.2900 -25.5500
35 C1b C 12.6000 -19.9500
36 C8y C 13.7900 -19.2500
37 C8x C 15.0500 -19.9500
38 C8x C 16.2400 -19.1800
39 C8x C 16.2400 -17.7800
40 C8x C 14.9800 -17.0800
41 C8x C 13.7900 -17.8500
BOND 41
1 3 4 1
2 3 5 1
3 4 6 1
4 5 7 1
5 6 8 1
6 8 9 1
7 9 10 1
8 10 11 1
9 10 12 2
10 13 11 1 #Up
11 7 14 2
12 14 15 1
13 15 16 2
14 16 17 1
15 17 18 2
16 7 18 1
17 16 19 1
18 6 20 1 #Up
19 20 21 1
20 21 22 1
21 5 23 2
22 5 24 2
23 21 25 1
24 21 26 2
25 13 27 1
26 13 28 1
27 28 29 1
28 29 30 1
29 27 30 1
30 3 31 1
31 31 32 1
32 32 33 1
33 32 34 1
34 8 35 1 #Up
35 35 36 1
36 36 37 2
37 37 38 1
38 38 39 2
39 39 40 1
40 40 41 2
41 36 41 1
BRACKET 1 21.2800 -19.8800 21.2800 -17.7800
1 24.2200 -17.7800 24.2200 -19.8800
1 x
ORIGINAL 1 1
REPEAT 1
|
|---|
