| Entry |
|
|---|
| Name |
Fosamprenavir calcium (USAN);
Lexiva (TN);
Telzir (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C25H34N3O9PS. Ca
|
|---|
| Exact mass |
623.1379
|
|---|
| Mol weight |
623.67
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antiviral
DG03107 Anti-HIV agent
DG01647 HIV protease inhibitor
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
|
|---|
| Remark |
| Product (DG00656): | D03835<US> |
|
|---|
| Efficacy |
Antiviral, HIV protease inhibitor |
|---|
| Disease |
|
|---|
| Comment |
Active form of prodrug: Amprenavir [DR: D00894]
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
CYP inhibition: CYP3A4 [HSA: 1576]
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J05 ANTIVIRALS FOR SYSTEMIC USE
J05A DIRECT ACTING ANTIVIRALS
J05AE Protease inhibitors
J05AE07 Fosamprenavir
D03835 Fosamprenavir calcium (USAN) <US>
USP drug classification [BR:br08302]
Antivirals
Anti-HIV Agents, Protease Inhibitors (PI)
Fosamprenavir
D03835 Fosamprenavir calcium (USAN)
Drug groups [BR:br08330]
Antiviral
DG03107 Anti-HIV agent
DG01647 HIV protease inhibitor
DG00656 Fosamprenavir
D03835 Fosamprenavir calcium
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00656 Fosamprenavir
D03835 Fosamprenavir calcium
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00656 Fosamprenavir
D03835 Fosamprenavir calcium
Drug classes [BR:br08332]
Antiviral
DG03107 Anti-HIV agent
D03835 Fosamprenavir calcium
Antimicrobials [BR:br08307]
Antivirals
Polyprotein cleavage inhibitor
HIV protease inhibitor
D03835 Fosamprenavir calcium (USAN) <US>
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D03835
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D03835
Drug groups [BR:br08330]
Antiviral
DG03107 Anti-HIV agent
DG01647 HIV protease inhibitor
DG00656 Fosamprenavir
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00656 Fosamprenavir
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00656 Fosamprenavir
Antimicrobials abbreviations [BR:br08327]
Antivirals
Polyprotein cleavage inhibitor
HIV protease inhibitor
DG00656 Fosamprenavir
Prodrugs [br08324.html]
DG00656
|
|---|
| Other DBs |
|
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| LinkDB |
|
|---|
| KCF data |
ATOM 40
1 Z Ca 14.7700 -21.1400 #2+
2 N1c N 22.8900 -17.2200
3 C1b C 21.7700 -16.5200
4 S4a S 24.4300 -16.5200
5 C1c C 20.5800 -17.2200
6 C8y C 25.8300 -17.2200
7 C1c C 19.3900 -16.5200
8 N1b N 18.2700 -17.2200
9 C7a C 17.0800 -16.5200
10 O7a O 15.8900 -17.2200
11 O6a O 17.0800 -15.1900
12 C1y C 14.7000 -16.5900
13 C8x C 25.8300 -18.6200
14 C8x C 27.0200 -19.2500
15 C8y C 28.1400 -18.6200
16 C8x C 28.1400 -17.2200
17 C8x C 27.0200 -16.5200
18 N1a N 29.4000 -19.3200
19 O2b O 20.5800 -19.2500
20 P1b P 19.3900 -20.0200
21 O1c O 17.8500 -20.7900 #-
22 O3c O 23.4500 -15.6100
23 O3c O 25.3400 -15.6100
24 O1c O 20.0900 -21.2100 #-
25 O1c O 18.6900 -18.8300
26 C1x C 14.7000 -15.2600
27 C1x C 13.4400 -17.0100
28 C1x C 12.6000 -15.9600
29 O2x O 13.4400 -14.8400
30 C1b C 22.8900 -18.6200
31 C1c C 24.0800 -19.3900
32 C1a C 25.3400 -18.6900
33 C1a C 24.0800 -20.7200
34 C1b C 19.3900 -15.1200
35 C8y C 20.5800 -14.4200
36 C8x C 21.8400 -15.1200
37 C8x C 23.0300 -14.3500
38 C8x C 23.0300 -12.9500
39 C8x C 21.7700 -12.2500
40 C8x C 20.5800 -13.0200
BOND 41
1 2 3 1
2 2 4 1
3 3 5 1
4 4 6 1
5 5 7 1
6 7 8 1
7 8 9 1
8 9 10 1
9 9 11 2
10 12 10 1 #Up
11 6 13 2
12 13 14 1
13 14 15 2
14 15 16 1
15 16 17 2
16 6 17 1
17 15 18 1
18 5 19 1 #Up
19 19 20 1
20 20 21 1
21 4 22 2
22 4 23 2
23 20 24 1
24 20 25 2
25 12 26 1
26 12 27 1
27 27 28 1
28 28 29 1
29 26 29 1
30 2 30 1
31 30 31 1
32 31 32 1
33 31 33 1
34 7 34 1 #Up
35 34 35 1
36 35 36 2
37 36 37 1
38 37 38 2
39 38 39 1
40 39 40 2
41 35 40 1
|
|---|
