| Entry |
|
|---|
| Name |
Anagrelide hydrochloride (USP);
Agrylin (TN);
Xagrid (TN) |
|---|
| Formula |
C10H7Cl2N3O. HCl
|
|---|
| Exact mass |
290.9733
|
|---|
| Mol weight |
292.549
|
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| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01507 Phosphodiesterase III inhibitor
Metabolizing enzyme substrate
DG01891 CYP1A1 substrate
DG01892 CYP1A2 substrate
|
|---|
| Remark |
| Product (DG00727): | D10255<JP/US> |
|
|---|
| Efficacy |
Thrombocythemia treatment, Platelet aggregation inhibitor, Phosphodiesterase inhibitor |
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP1A1 [HSA: 1543], CYP1A2 [HSA: 1544]
|
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| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01X OTHER ANTINEOPLASTIC AGENTS
L01XX Other antineoplastic agents
L01XX35 Anagrelide
D02933 Anagrelide hydrochloride (USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01507 Phosphodiesterase III inhibitor
DG00727 Anagrelide
D02933 Anagrelide hydrochloride
Metabolizing enzyme substrate
DG01891 CYP1A1 substrate
DG00727 Anagrelide
D02933 Anagrelide hydrochloride
DG01892 CYP1A2 substrate
DG00727 Anagrelide
D02933 Anagrelide hydrochloride
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Phosphodiesterases
PDE3
D02933 Anagrelide hydrochloride (USP)
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D02933
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02933
Drug groups [BR:br08330]
Cardiovascular agent
DG01507 Phosphodiesterase III inhibitor
DG00727 Anagrelide
Metabolizing enzyme substrate
DG01891 CYP1A1 substrate
DG00727 Anagrelide
DG01892 CYP1A2 substrate
DG00727 Anagrelide
|
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| Other DBs |
|
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| LinkDB |
|
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| KCF data |
ATOM 17
1 N1y N 9.8700 -6.3000
2 C2y C 9.8700 -7.7000
3 N2x N 8.6800 -8.4000
4 C8y C 7.4200 -7.7000
5 C8y C 7.4200 -6.3000
6 C1x C 8.6100 -5.6000
7 C8y C 6.2076 -5.6000
8 C8y C 4.9951 -6.3000
9 C8x C 4.9951 -7.7000
10 C8x C 6.2076 -8.4000
11 X Cl 6.2076 -4.2000
12 X Cl 3.7827 -5.6000
13 N1x N 11.2015 -8.1326
14 C5x C 12.0244 -7.0000
15 C1x C 11.2015 -5.8674
16 O5x O 13.4244 -7.0000
17 X Cl 16.7300 -7.9800
BOND 18
1 2 3 2
2 3 4 1
3 4 5 2
4 5 6 1
5 6 1 1
6 1 2 1
7 5 7 1
8 7 8 2
9 8 9 1
10 9 10 2
11 10 4 1
12 7 11 1
13 8 12 1
14 2 13 1
15 13 14 1
16 14 15 1
17 1 15 1
18 14 16 2
|
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