KEGG   DRUG: Apixaban
Entry
D03213                      Drug                                   

Name
Apixaban (JAN/USAN/INN);
Eliquis (TN)
Product
  Generic
Formula
C25H25N5O4
Exact mass
459.1907
Mol weight
459.4971
Structure
Class
Blood modifier agent
 DG01950  Antithrombotic agent
  DG01662  Factor Xa inhibitor
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
 DG02925  CYP3A5 substrate
Transporter substrate
 DG01665  ABCB1 substrate
 DG01913  ABCG2 substrate
Remark
Therapeutic category: 3339
ATC code: B01AF02
Product: D03213<JP/US>
Efficacy
Anticoagulant, Antithrombotic, Factor Xa inhibitor
  Disease
Deep vein thrombosis [DS:H01723]
Target
F10 [HSA:2159] [KO:K01314]
  Pathway
hsa04610  Complement and coagulation cascades
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577]
Transporter: ABCB1 [HSA:5243], ABCG2 [HSA:9429]
Interaction
Structure map
map07049  Antithrombosis agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AF Direct factor Xa inhibitors
     B01AF02 Apixaban
      D03213  Apixaban (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Blood Products and Modifiers
  Anticoagulants
   Factor Xa Inhibitors, direct
    Apixaban
     D03213  Apixaban (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   333  Anticoagulants
    3339  Others
     D03213  Apixaban (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Serine peptidases
    F10
     D03213  Apixaban (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D03213
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03213
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03213
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D03213
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D03213
 Drug transporters
  D03213
Other DBs
CAS: 503612-47-3
PubChem: 17397366
ChEBI: 72296
ChEMBL: CHEMBL231779
PDB-CCD: GG2[PDBj]
LigandBox: D03213
NIKKAJI: J2.566.952E
LinkDB
KCF data

ATOM        34
            1   C1x C    21.2579  -15.3879
            2   C1x C    21.2579  -16.7863
            3   C5x C    22.4689  -17.4855
            4   N1y N    23.6799  -16.7863
            5   C1x C    23.6799  -15.3879
            6   C1x C    22.4689  -14.6887
            7   C8y C    24.9097  -17.4965
            8   C8x C    24.9094  -18.8839
            9   C8x C    26.1203  -19.5833
            10  C8y C    27.3315  -18.8845
            11  C8x C    27.3318  -17.4971
            12  C8x C    26.1209  -16.7976
            13  N1y N    28.5492  -19.5878
            14  C1x C    28.5489  -20.9815
            15  C1x C    29.7597  -21.6809
            16  C8y C    30.9709  -20.9822
            17  C8y C    30.9714  -19.5886
            18  C5x C    29.7605  -18.8890
            19  O5x O    22.4689  -18.8838
            20  O5x O    29.7609  -17.4858
            21  C8y C    32.2962  -21.4131
            22  N5x N    33.1156  -20.2860
            23  N4y N    32.2968  -19.1583
            24  C8y C    32.7204  -17.8544
            25  C5a C    32.7279  -22.7430
            26  N1a N    34.1279  -22.7430
            27  O5a O    31.9130  -23.8647
            28  C8x C    34.1204  -17.8544
            29  C8x C    34.8204  -16.6420
            30  C8y C    34.1204  -15.4296
            31  C8x C    32.7204  -15.4296
            32  C8x C    32.0204  -16.6420
            33  O2a O    34.8256  -14.2088
            34  C1a C    36.2600  -14.2091
BOND        38
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13    7  12 1
            14   10  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   13  18 1
            21    3  19 2
            22   18  20 2
            23   16  21 1
            24   21  22 2
            25   22  23 1
            26   17  23 1
            27   23  24 1
            28   21  25 1
            29   25  26 1
            30   25  27 2
            31   24  28 1
            32   28  29 2
            33   29  30 1
            34   30  31 2
            35   31  32 1
            36   24  32 2
            37   30  33 1
            38   33  34 1

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