KEGG   DISEASE: Deep vein thrombosis
Entry
H01723                      Disease                                

Name
Deep vein thrombosis
Description
Deep vein thrombosis (DVT) is the formation of blood clots (thrombi) in the deep veins. It can lead to complications such as postphlebitic syndrome, pulmonary embolism and death. DVT has genetic and acquired risk factors. The genetic risk factors can be subdivided into those that are strong, moderate and weak. Strong risk factors are deficiencies of antithrombin, protein C and protein S. Moderately strong are factor V Leiden, prothrombin 20210A, non-O blood group and fibrinogen 10034T. There are many weak genetic risk factors, including fibrinogen, factor XIII and factor XI variants. Acquired risk factors include surgery, oral contraceptives, trauma, obesity, cancer, and so on. In some patients, venous thrombosis occurs in the presence of such risk factors for DVT. These patients are classified as having secondary DVT. In the other patients, no predisposing factors are found, and thus, are considered as having an idiopathic DVT.
Category
Hematologic disease
Brite
Human diseases [BR:br08402]
 Cardiovascular diseases
  Vascular diseases
   H01723  Deep vein thrombosis
Human diseases in ICD-11 classification [BR:br08403]
 11 Diseases of the circulatory system
  Diseases of veins
   BD71  Deep vein thrombosis
    H01723  Deep vein thrombosis
Related
pathway
hsa04610  Complement and coagulation cascades
Gene
Antithrombin (deficiency) [HSA:462] [KO:K03911]
Protein C (deficiency) [HSA:5624] [KO:K01344]
Protein S (deficiency) [HSA:5627] [KO:K03908]
Drug
Dalteparin sodium [DR:D03353]
Apixaban [DR:D03213]
Other DBs
ICD-11: BD71
ICD-10: I80.2
MeSH: D020246
Reference
PMID:8568483
  Authors
Bastounis EA, Karayiannakis AJ, Makri GG, Alexiou D, Papalambros EL
  Title
The incidence of occult cancer in patients with deep venous thrombosis: a prospective study.
  Journal
J Intern Med 239:153-6 (1996)
DOI:10.1046/j.1365-2796.1996.426000.x
Reference
  Authors
Scarvelis D, Wells PS
  Title
Diagnosis and treatment of deep-vein thrombosis.
  Journal
CMAJ 175:1087-92 (2006)
DOI:10.1503/cmaj.060366
Reference
  Authors
Rosendaal FR, Reitsma PH
  Title
Genetics of venous thrombosis.
  Journal
J Thromb Haemost 7 Suppl 1:301-4 (2009)
DOI:10.1111/j.1538-7836.2009.03394.x
Reference
PMID:19784750 (drug)
  Authors
Spiezia L, Simioni P
  Title
Upper extremity deep vein thrombosis.
  Journal
Intern Emerg Med 5:103-9 (2010)
DOI:10.1007/s11739-009-0320-x
Reference
  Authors
Kesieme E, Kesieme C, Jebbin N, Irekpita E, Dongo A
  Title
Deep vein thrombosis: a clinical review.
  Journal
J Blood Med 2:59-69 (2011)
DOI:10.2147/JBM.S19009
Reference
  Authors
Rosendaal FR
  Title
Causes of venous thrombosis.
  Journal
Thromb J 14:24 (2016)
DOI:10.1186/s12959-016-0108-y
Reference
PMID:27572888 (drug)
  Authors
Cote LP, Greenberg S, Caprini JA, Tafur A, Choi C, Munoz FJ, Skride A, Valero B, Porras JA, Ciammaichella M, Hernandez-Blasco LM, Monreal M
  Title
Comparisons Between Upper and Lower Extremity Deep Vein Thrombosis: A Review of the RIETE Registry.
  Journal
Clin Appl Thromb Hemost 23:748-754 (2017)
DOI:10.1177/1076029616663847
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