KEGG   DRUG: MecaserminHelp
Entry
D03297                      Drug                                   

Name
Mecasermin (USAN/INN);
Mecasermin (genetical recombination) (JAN);
Increlex (TN);
Myotrophin (TN)
Product
Formula
C331H512N94O101S7
Exact mass
7643.5862
Mol weight
7648.6312
Sequence
GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY
CAPLKPAKSA
(Disulfide bridge: 6-48, 18-61, 47-52)
  Type
Peptide
Remark
Therapeutic category: 2499
ATC code: H01AC03
Chemical structure group: DG01359
Product (DG01359): D03297<JP/US>
Efficacy
Antidiabetic, Insulin-like growth factor receptor agonist
  Disease
Primary IGF-1 deficiency [DS:H00254]
Comment
Recombinant Human Insulin-like growth factor I [HSA:3479] [KO:K05459]
Treatment of amyotrophic lateral sclerosis, Treatment of diabetes mellitus (types I and types II), Treatment of growth hormone insensitivity (GHIS)
Target
IGF1R (CD221) [HSA:3480] [KO:K05087]
GHR [HSA:2690] [KO:K05080]
  Pathway
hsa04151  PI3K-Akt signaling pathway
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H01 PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
   H01A ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES
    H01AC Somatropin and somatropin agonists
     H01AC03 Mecasermin
      D03297  Mecasermin (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Pituitary)
  Mecasermin
   D03297  Mecasermin (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2499  Others
     D03297  Mecasermin (USAN/INN); Mecasermin (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   INSR family
    IGF1R (CD221)
     D03297  Mecasermin (USAN/INN) <JP/US>
 Cytokines and receptors
  Cytokine receptors
   CSF and other factor receptors
    GHR
     D03297  Mecasermin (USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D03297
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03297
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D03297
BRITE hierarchy
Other DBs
CAS: 68562-41-4
PubChem: 17397448
NIKKAJI: J2.215.442G
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