Homo sapiens (human): 2690
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Entry
2690 CDS
T01001
Symbol
GHR, GHBP, GHIP
Name
(RefSeq) growth hormone receptor
KO
K05080
growth hormone receptor
Organism
hsa
Homo sapiens (human)
Pathway
hsa04060
Cytokine-cytokine receptor interaction
hsa04080
Neuroactive ligand-receptor interaction
hsa04151
PI3K-Akt signaling pathway
hsa04630
JAK-STAT signaling pathway
hsa04935
Growth hormone synthesis, secretion and action
Network
nt06324
GHRH-GH-IGF signaling
nt06518
JAK-STAT signaling
Element
N00907
GH-Jak-STAT signaling pathway
N01555
Hormone-like-cytokine to Jak-STAT signaling pathway
Disease
H00155
Familial hypercholesterolemia
H00254
Growth hormone deficiency
H02037
Laron syndrome
Drug target
Atesidorsen:
D11161
Atesidorsen sodium:
D11162
Lonapegsomatropin:
D11486
<US>
Mecasermin:
D03297
<JP/US>
Mecasermin rinfabate:
D04870
Pegvisomant:
D05394
<JP/US>
Somapacitan:
D11194
<JP/US>
Somatrem:
D05884
Somatrogon:
D10990
<JP/US>
Somatropin:
D02691
<JP/US>
Somavaratan:
D11193
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
2690 (GHR)
04151 PI3K-Akt signaling pathway
2690 (GHR)
09133 Signaling molecules and interaction
04080 Neuroactive ligand-receptor interaction
2690 (GHR)
04060 Cytokine-cytokine receptor interaction
2690 (GHR)
09150 Organismal Systems
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
2690 (GHR)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04050 Cytokine receptors [BR:
hsa04050
]
2690 (GHR)
Cytokine receptors [BR:
hsa04050
]
Interleukin receptor families
Prolactin receptor family
2690 (GHR)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
GHBP
EpoR_lig-bind
fn3
CRLF2-like_D2
Motif
Other DBs
NCBI-GeneID:
2690
NCBI-ProteinID:
NP_000154
OMIM:
600946
HGNC:
4263
Ensembl:
ENSG00000112964
Pharos:
P10912
(Tclin)
UniProt:
P10912
Structure
PDB
LinkDB
All DBs
Position
5:42423439..42721878
Genome browser
AA seq
638 aa
AA seq
DB search
MDLWQLLLTLALAGSSDAFSGSEATAAILSRAPWSLQSVNPGLKTNSSKEPKFTKCRSPE
RETFSCHWTDEVHHGTKNLGPIQLFYTRRNTQEWTQEWKECPDYVSAGENSCYFNSSFTS
IWIPYCIKLTSNGGTVDEKCFSVDEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRN
ADIQKGWMVLEYELQYKEVNETKWKMMDPILTTSVPVYSLKVDKEYEVRVRSKQRNSGNY
GEFSEVLYVTLPQMSQFTCEEDFYFPWLLIIIFGIFGLTVMLFVFLFSKQQRIKMLILPP
VPVPKIKGIDPDLLKEGKLEEVNTILAIHDSYKPEFHSDDSWVEFIELDIDEPDEKTEES
DTDRLLSSDHEKSHSNLGVKDGDSGRTSCCEPDILETDFNANDIHEGTSEVAQPQRLKGE
ADLLCLDQKNQNNSPYHDACPATQQPSVIQAEKNKPQPLPTEGAESTHQAAHIQLSNPSS
LSNIDFYAQVSDITPAGSVVLSPGQKNKAGMSQCDMHPEMVSLCQENFLMDNAYFCEADA
KKCIPVAPHIKVESHIQPSLNQEDIYITTESLTTAAGRPGTGEHVPGSEMPVPDYTSIHI
VQSPQGLILNATALPLPDKEFLSSCGYVSTDQLNKIMP
NT seq
1917 nt
NT seq
+upstream
nt +downstream
nt
atggatctctggcagctgctgttgaccttggcactggcaggatcaagtgatgctttttct
ggaagtgaggccacagcagctatccttagcagagcaccctggagtctgcaaagtgttaat
ccaggcctaaagacaaattcttctaaggagcctaaattcaccaagtgccgttcacctgag
cgagagactttttcatgccactggacagatgaggttcatcatggtacaaagaacctagga
cccatacagctgttctataccagaaggaacactcaagaatggactcaagaatggaaagaa
tgccctgattatgtttctgctggggaaaacagctgttactttaattcatcgtttacctcc
atctggataccttattgtatcaagctaactagcaatggtggtacagtggatgaaaagtgt
ttctctgttgatgaaatagtgcaaccagatccacccattgccctcaactggactttactg
aacgtcagtttaactgggattcatgcagatatccaagtgagatgggaagcaccacgcaat
gcagatattcagaaaggatggatggttctggagtatgaacttcaatacaaagaagtaaat
gaaactaaatggaaaatgatggaccctatattgacaacatcagttccagtgtactcattg
aaagtggataaggaatatgaagtgcgtgtgagatccaaacaacgaaactctggaaattat
ggcgagttcagtgaggtgctctatgtaacacttcctcagatgagccaatttacatgtgaa
gaagatttctactttccatggctcttaattattatctttggaatatttgggctaacagtg
atgctatttgtattcttattttctaaacagcaaaggattaaaatgctgattctgccccca
gttccagttccaaagattaaaggaatcgatccagatctcctcaaggaaggaaaattagag
gaggtgaacacaatcttagccattcatgatagctataaacccgaattccacagtgatgac
tcttgggttgaatttattgagctagatattgatgagccagatgaaaagactgaggaatca
gacacagacagacttctaagcagtgaccatgagaaatcacatagtaacctaggggtgaag
gatggcgactctggacgtaccagctgttgtgaacctgacattctggagactgatttcaat
gccaatgacatacatgagggtacctcagaggttgctcagccacagaggttaaaaggggaa
gcagatctcttatgccttgaccagaagaatcaaaataactcaccttatcatgatgcttgc
cctgctactcagcagcccagtgttatccaagcagagaaaaacaaaccacaaccacttcct
actgaaggagctgagtcaactcaccaagctgcccatattcagctaagcaatccaagttca
ctgtcaaacatcgacttttatgcccaggtgagcgacattacaccagcaggtagtgtggtc
ctttccccgggccaaaagaataaggcagggatgtcccaatgtgacatgcacccggaaatg
gtctcactctgccaagaaaacttccttatggacaatgcctacttctgtgaggcagatgcc
aaaaagtgcatccctgtggctcctcacatcaaggttgaatcacacatacagccaagctta
aaccaagaggacatttacatcaccacagaaagccttaccactgctgctgggaggcctggg
acaggagaacatgttccaggttctgagatgcctgtcccagactatacctccattcatata
gtacagtccccacagggcctcatactcaatgcgactgccttgcccttgcctgacaaagag
tttctctcatcatgtggctatgtgagcacagaccaactgaacaaaatcatgccttag
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