| Entry |
|
|---|
| Name |
Canrenone (USAN) |
|---|
| Formula |
C22H28O3
|
|---|
| Exact mass |
340.2038
|
|---|
| Mol weight |
340.45
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG03231 Antihypertensive
DG01676 Aldosterone antagonist
DG01885 Potassium-sparing diuretic
|
|---|
| Remark |
|
|---|
| Efficacy |
Diuretic, Aldosterone antagonist |
|---|
| Comment |
Spironolactone derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04960 | Aldosterone-regulated sodium reabsorption |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C03 DIURETICS
C03D ALDOSTERONE ANTAGONISTS AND OTHER POTASSIUM-SPARING AGENTS
C03DA Aldosterone antagonists
C03DA03 Canrenone
D03363 Canrenone (USAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG03231 Antihypertensive
DG01676 Aldosterone antagonist
D03363 Canrenone
DG01885 Potassium-sparing diuretic
D03363 Canrenone
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C2 (MR)
D03363 Canrenone (USAN)
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 25
1 C1z C 26.1100 -21.4200
2 C1z C 24.8500 -22.1200
3 C1x C 27.2300 -22.1200
4 O7x O 27.2300 -20.6500
5 C1x C 24.9900 -20.6500
6 C1y C 24.8500 -23.4500
7 C1x C 23.7300 -21.4200
8 C1a C 24.2200 -20.5800
9 C1x C 27.2300 -23.4500
10 C7x C 26.8100 -19.3200
11 C1x C 25.4100 -19.3200
12 C1y C 23.7300 -24.1500
13 C1x C 22.5400 -22.1200
14 O6a O 27.5800 -18.2700
15 C1y C 22.5400 -23.4500
16 C2x C 23.7300 -25.5500
17 C1z C 21.3500 -24.1500
18 C2x C 22.5400 -26.1800
19 C2y C 21.3500 -25.4800
20 C1x C 20.1600 -23.4500
21 C1a C 21.3500 -22.7500
22 C2x C 20.1600 -26.1800
23 C1x C 18.9700 -24.1500
24 C5x C 18.9700 -25.4800
25 O5x O 17.7800 -26.1800
BOND 29
1 1 2 1
2 1 3 1
3 1 4 1 #Up
4 1 5 1 #Down
5 2 6 1
6 2 7 1
7 2 8 1 #Up
8 3 9 1
9 4 10 1
10 5 11 1
11 6 12 1
12 7 13 1
13 10 14 2
14 12 15 1
15 12 16 1
16 15 17 1
17 16 18 2
18 17 19 1
19 17 20 1
20 17 21 1 #Up
21 19 22 2
22 20 23 1
23 22 24 1
24 24 25 2
25 6 9 1
26 10 11 1
27 13 15 1
28 18 19 1
29 23 24 1
|
|---|
