Homo sapiens (human): 4306
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Entry
4306 CDS
T01001
Symbol
NR3C2, MCR, MLR, MR, NR3C2VIT
Name
(RefSeq) nuclear receptor subfamily 3 group C member 2
KO
K08555
mineralocorticoid receptor
Organism
hsa
Homo sapiens (human)
Pathway
hsa04960
Aldosterone-regulated sodium reabsorption
Disease
H00243
Hyperkalemic distal renal tubular acidosis (RTA type 4)
H00603
Hypertension exacerbated in pregnancy
H01633
High blood pressure
H02310
Renal tubular acidosis
Drug target
Aldosterone:
D10528
Canrenone:
D03363
Desoxycortone (
DG00507
):
D03698
D03699
D07792
Dicirenone:
D03792
Drospirenone:
D03917
<US>
Eplerenone:
D01115
<JP/US>
Esaxerenone:
D10892
<JP>
Finerenone:
D10633
<JP/US>
Fludrocortisone (
DG00506
):
D00986
<JP/US>
D07967
Mexrenoate potassium:
D05020
Miricorilant:
D11667
Potassium canrenoate:
D01943
<JP>
Prorenoate potassium:
D05640
Spironolactone:
D00443
<JP/US>
Spiroxasone:
D05912
Triamterene:
D00386
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
4306 (NR3C2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
4306 (NR3C2)
09183 Protein families: signaling and cellular processes
03310 Nuclear receptors [BR:
hsa03310
]
4306 (NR3C2)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
Zinc finger
Cys4 estrogen receptor-like
4306 (NR3C2)
Nuclear receptors [BR:
hsa03310
]
3. Estrogen like
3C. 3-Ketosteroid receptor
4306 (NR3C2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
zf-C4
Hormone_recep
Motif
Other DBs
NCBI-GeneID:
4306
NCBI-ProteinID:
NP_000892
OMIM:
600983
HGNC:
7979
Ensembl:
ENSG00000151623
UniProt:
P08235
B0ZBF6
Structure
PDB
LinkDB
All DBs
Position
4:complement(148078764..148445508)
Genome browser
AA seq
984 aa
AA seq
DB search
METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNST
QGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYE
QQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAV
VKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPN
VENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSP
ANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVP
SPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSD
SSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGF
DGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSAR
DQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPS
KICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRL
QKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVN
TALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQV
VKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKM
HQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYI
KELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAML
VEIISDQLPKVESGNAKPLYFHRK
NT seq
2955 nt
NT seq
+upstream
nt +downstream
nt
atggagaccaaaggctaccacagtctccctgaaggtctagatatggaaagacggtggggt
caagtttctcaggctgtggagcgttcttccctgggacctacagagaggaccgatgagaat
aactacatggagattgtcaacgtaagctgtgtttccggtgctattccaaacaacagtact
caaggaagcagcaaagaaaaacaagaactactcccttgccttcagcaagacaataatcgg
cctgggattttaacatctgatattaaaactgagctggaatctaaggaactttcagcaact
gtagctgagtccatgggtttatatatggattctgtaagagatgctgactattcctatgag
cagcagaaccaacaaggaagcatgagtccagctaagatttatcagaatgttgaacagctg
gtgaaattttacaaaggaaatggccatcgtccttccactctaagttgtgtgaacacgccc
ttgagatcatttatgtctgactctgggagctccgtgaatggtggcgtcatgcgcgccgtt
gttaaaagccctatcatgtgtcatgagaaaagcccgtctgtttgcagccctctgaacatg
acatcttcggtttgcagccctgctggaatcaactctgtgtcctccaccacagccagcttt
ggcagttttccagtgcacagcccaatcacccagggaactcctctgacatgctcccctaat
gttgaaaatcgaggctccaggtcgcacagccctgcacatgctagcaatgtgggctctcct
ctctcaagtccgttaagtagcatgaaatcctcaatttccagccctccaagtcactgcagt
gtaaaatctccagtctccagtcccaataatgtcactctgagatcctctgtgtctagccct
gcaaatattaacaactcaaggtgctctgtttccagcccttcgaacactaataacagatcc
acgctttccagtccggcagccagtactgtgggatctatctgtagccctgtaaacaatgcc
ttcagctacactgcttctggcacctctgctggatccagtacattgcgggatgtggttccc
agtccagacacgcaggagaaaggtgctcaagaggtcccttttcctaagactgaggaagta
gagagtgccatctcaaatggtgtgactggccagcttaatattgtccagtacataaaacca
gaaccagatggagcttttagcagctcatgtctaggaggaaatagcaaaataaattcggat
tcttcattctcagtaccaataaagcaagaatcaaccaagcattcatgttcaggcacctct
tttaaagggaatccaacagtaaacccgtttccatttatggatggctcgtatttttccttt
atggatgataaagactattattccctatcaggaattttaggaccacctgtgcccggcttt
gatggtaactgtgaaggcagcggattcccagtgggtattaaacaagaaccagatgatggg
agctattacccagaggccagcatcccttcctctgctattgttggggtgaattcaggtgga
cagtccttccactacaggattggtgctcaaggtacaatatctttatcacgatcggctaga
gaccaatctttccaacacctgagttcctttcctcctgtcaatactttagtggagtcatgg
aaatcacacggcgacctgtcgtctagaagaagtgatgggtatccggtcttagaatacatt
ccagaaaatgtatcaagctctactttacgaagtgtttctactggatcttcaagaccttca
aaaatatgtttggtgtgtggggatgaggcttcaggatgccattatggggtagtcacctgt
ggcagctgcaaagttttcttcaaaagagcagtggaagggcaacacaactatttatgtgct
ggaagaaatgattgcatcattgataagattcgacgaaagaattgtcctgcttgcagactt
cagaaatgtcttcaagctggaatgaatttaggagcacgaaagtcaaagaagttgggaaag
ttaaaagggattcacgaggagcagccacagcagcagcagcccccacccccacccccaccc
ccgcaaagcccagaggaagggacaacgtacatcgctcctgcaaaagaaccctcggtcaac
acagcactggttcctcagctctccacaatctcacgagcgctcacaccttcccccgttatg
gtccttgaaaacattgaacctgaaattgtatatgcaggctatgacagctcaaaaccagat
acagccgaaaatctgctctccacgctcaaccgcttagcaggcaaacagatgatccaagtc
gtgaagtgggcaaaggtacttccaggatttaaaaacttgcctcttgaggaccaaattacc
ctaatccagtattcttggatgtgtctatcatcatttgccttgagctggagatcgtacaaa
catacgaacagccaatttctctattttgcaccagacctagtctttaatgaagagaagatg
catcagtctgccatgtatgaactatgccaggggatgcaccaaatcagccttcagttcgtt
cgactgcagctcacctttgaagaatacaccatcatgaaagttttgctgctactaagcaca
attccaaaggatggcctcaaaagccaggctgcatttgaagaaatgaggacaaattacatc
aaagaactgaggaagatggtaactaagtgtcccaacaattctgggcagagctggcagagg
ttctaccaactgaccaagctgctggactccatgcatgacctggtgagcgacctgctggaa
ttctgcttctacaccttccgagagtcccatgcgctgaaggtagagttccccgcaatgctg
gtggagatcatcagcgaccagctgcccaaggtggagtcggggaacgccaagccgctctac
ttccaccggaagtga
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