KEGG ORTHOLOGY: K08555

ORTHOLOGY: K08555

Entry

K08555                      KO

Symbol

NR3C2, MR

Name

mineralocorticoid receptor

Pathway

map04960

Aldosterone-regulated sodium reabsorption

Disease

H00243

Hyperkalemic distal renal tubular acidosis (RTA type 4)

H00603

Hypertension exacerbated in pregnancy

H01633

High blood pressure

H02310

Renal tubular acidosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K08555  NR3C2, MR; mineralocorticoid receptor
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K08555  NR3C2, MR; mineralocorticoid receptor
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors
    K08555  NR3C2, MR; mineralocorticoid receptor
Transcription factors [BR:ko03000]
Eukaryotic type
  Zinc finger
   Cys4 estrogen receptor-like
    K08555  NR3C2, MR; mineralocorticoid receptor
Nuclear receptors [BR:ko03310]
3. Estrogen like
  3C. 3-Ketosteroid receptor
   K08555  NR3C2, MR; mineralocorticoid receptor

Genes

HSA:	4306(NR3C2)

PTR:	461533(NR3C2)

PPS:	100970550(NR3C2)

GGO:	101137339(NR3C2)

PON:	100172884(NR3C2)

NLE:	100584329(NR3C2)

HMH:	116464826(NR3C2)

MCC:	704789(NR3C2)

MCF:	102118229(NR3C2)

MTHB:

126954881

MNI:	105463453(NR3C2)

CSAB:

103236358(NR3C2)

CATY:

105580729(NR3C2)

PANU:

101025845(NR3C2)

TGE:	112624577(NR3C2)

MLEU:

105534518(NR3C2)

RRO:	104666371(NR3C2)

RBB:	108514048(NR3C2)

TFN:	117086001(NR3C2)

PTEH:

111552910(NR3C2)

CANG:

105522241(NR3C2)

CJC:	100405081(NR3C2)

SBQ:	101031058(NR3C2)

CIMI:

108307346(NR3C2)

CSYR:

103267459(NR3C2)

MMUR:

105881834(NR3C2)

LCAT:

123638474(NR3C2)

PCOQ:

105822965(NR3C2)

OGA:	100956592(NR3C2)

MMU:	110784(Nr3c2)

MCAL:

110299932(Nr3c2)

MPAH:

110337580(Nr3c2)

RNO:	25672(Nr3c2)

MCOC:

116069596(Nr3c2)

ANU:	117723230(Nr3c2)

CGE:	100750556(Nr3c2)

MAUA:

101833082(Nr3c2)

PROB:

127237554(Nr3c2)

PLEU:

114709925(Nr3c2)

MORG:

121455666(Nr3c2)

MFOT:

126489136

AAMP:

119802080(Nr3c2)

NGI:	103748464(Nr3c2)

CPOC:

100735309(Nr3c2)

CCAN:

109697651(Nr3c2)

DORD:

105995668(Nr3c2)

DSP:	122127257(Nr3c2)

PLOP:

125341668(Nr3c2)

NCAR:

124995063

OCU:	100358449 103349910

OPI:	101519367(NR3C2)

TUP:	102497749(NR3C2)

GVR:	103587359(NR3C2)

CFA:	475461(NR3C2)

CLUD:

112654352(NR3C2)

VVP:	112934698(NR3C2)

VLG:	121481067(NR3C2)

NPO:	129516861(NR3C2)

AML:

100475310

UMR:	103658011(NR3C2)

UAH:	113255738(NR3C2)

UAR:	123793227(NR3C2)

ELK:

111154998

LLV:

125093025

MPUF:

101687999(NR3C2)

MNP:	132000083(NR3C2)

NVS:	122889597(NR3C2)

ORO:	101386208(NR3C2)

EJU:	114225556(NR3C2)

ZCA:	113925303(NR3C2)

MLX:	118022257(NR3C2)

NSU:	110588473(NR3C2)

LWW:

102745228

FCA:	101081977(NR3C2)

PYU:	121028744(NR3C2)

PCOO:

112858014(NR3C2)

PBG:	122475715(NR3C2)

LRUF:

124520702

PTG:	102951221(NR3C2)

PPAD:

109262546(NR3C2)

PUC:

125923141

AJU:

106983308

HHV:	120246309(NR3C2)

BTA:	537614(NR3C2)

BOM:

102269594

BIU:	109571245(NR3C2)

BBUB:

102395884(NR3C2)

BBIS:

104989175(NR3C2)

CHX:	102172834(NR3C2)

OAS:	101107046(NR3C2)

BTAX:

128062237(NR3C2)

ODA:	120871451(NR3C2)

CCAD:

122451839(NR3C2)

MBEZ:

129542840(NR3C2)

SSC:	100620970(NR3C2)

CFR:	102520495(NR3C2)

CBAI:

105071334

CDK:	105091218(NR3C2)

VPC:	102533849(NR3C2)

BACU:

103008784(NR3C2)

LVE:

103088347

OOR:	101271468(NR3C2)

DLE:	111187724(NR3C2)

PCAD:

102988649(NR3C2)

PSIU:

116754584(NR3C2)

NASI:

112393788(NR3C2)

ECB:	100062570(NR3C2)

EPZ:	103546877(NR3C2)

EAI:	106829181(NR3C2)

MYB:	102248146(NR3C2)

MYD:	102768764(NR3C2)

MMYO:

118657639(NR3C2)

MLF:	102439464(NR3C2)

MNA:	107532505(NR3C2)

PKL:	118711689(NR3C2)

EFUS:

103288266(NR3C2)

HAI:	109392734(NR3C2)

DRO:	112312235(NR3C2)

SHON:

118995411(NR3C2)

AJM:	119061719(NR3C2)

PDIC:

114502878(NR3C2)

PHAS:

123813735(NR3C2)

MMF:	118615756(NR3C2)

RFQ:	117037965(NR3C2)

PALE:

102897003(NR3C2)

PGIG:

120613307(NR3C2)

PVP:	105291547(NR3C2)

RAY:	107517767(NR3C2)

MJV:	108398605(NR3C2)

TOD:	119234904(NR3C2)

SARA:

101545737(NR3C2)

LAV:	100661181(NR3C2)

TMU:

101349203

ETF:	101640378(NR3C2)

DNM:	101411727(NR3C2)

MDO:	100018377(NR3C2)

GAS:	123252957(NR3C2)

SHR:	100917276(NR3C2)

AFZ:

127540726

PCW:	110213647(NR3C2)

OAA:	100080085(NR3C2)

GGA:	374131(NR3C2)

PCOC:

116226132(NR3C2)

MGP:	100546597(NR3C2)

CJO:	107313140(NR3C2)

TPAI:

128084306(NR3C2)

LMUT:

125692302(NR3C2)

NMEL:

110398595(NR3C2)

APLA:

101798001(NR3C2)

ACYG:

106032234(NR3C2)

CATA:

118248720(NR3C2)

AFUL:

116488466(NR3C2)

TGU:	751776(NR3C2)

LSR:	110473779(NR3C2)

SCAN:

103826080(NR3C2)

PMOA:

120497221(NR3C2)

OTC:	121339854(NR3C2)

PRUF:

121365221(NR3C2)

GFR:	102038615(NR3C2)

FAB:	101819228(NR3C2)

OMA:	130252823(NR3C2)

PHI:	102111766(NR3C2)

PMAJ:

107202999(NR3C2)

CCAE:

111928848(NR3C2)

CCW:	104697243(NR3C2)

CBRC:

103622347(NR3C2)

ETL:	114062336(NR3C2)

ZAB:	102067653(NR3C2)

ACHL:

103800797

SVG:	106855683(NR3C2)

MMEA:

130575347(NR3C2)

HRT:	120752653(NR3C2)

FPG:	101917775(NR3C2)

FCH:	102057989(NR3C2)

CLV:	102095900(NR3C2)

EGZ:	104130587(NR3C2)

NNI:	104015967(NR3C2)

PCRI:

104038068(NR3C2)

PLET:

104615555

EHS:	104504792(NR3C2)

PCAO:

104040493

ACUN:

113479743(NR3C2)

TALA:

104367599(NR3C2)

PADL:

103919904(NR3C2)

AFOR:

103899757(NR3C2)

ACHC:

115336110(NR3C2)

HALD:

104314298(NR3C2)

HLE:	104837178(NR3C2)

AGEN:

126044820

GCL:

127015417

CCRI:

104163360(NR3C2)

CSTI:

104551575(NR3C2)

CMAC:

104484996(NR3C2)

MUI:	104544651(NR3C2)

BREG:

104632498(NR3C2)

FGA:	104069508(NR3C2)

GSTE:

104250265

LDI:	104341550(NR3C2)

MNB:	103771833(NR3C2)

OHA:	104337010(NR3C2)

NNT:

104401677

SHAB:

115610274(NR3C2)

DPUB:

104297115(NR3C2)

PGUU:

104464622

ACAR:

104519519

CPEA:

104398791(NR3C2)

AVIT:

104272353

CVF:	104291498(NR3C2)

RTD:	128909842(NR3C2)

CUCA:

104066080(NR3C2)

TEO:	104383508(NR3C2)

BRHI:

104497768

AAM:	106492011(NR3C2)

AROW:

112976368(NR3C2)

NPD:	112950124(NR3C2)

TGT:	104578584(NR3C2)

DNE:	112986851(NR3C2)

SCAM:

104153363(NR3C2)

ASN:	102368785(NR3C2)

AMJ:	102567668(NR3C2)

CPOO:

109309657(NR3C2)

GGN:	109301206(NR3C2)

PSS:	102456908(NR3C2)

CMY:	102932569(NR3C2)

CCAY:

125635337(NR3C2)

DCC:	119854303(NR3C2)

CPIC:

101937034(NR3C2)

TST:	117878325(NR3C2)

CABI:

116832480(NR3C2)

MRV:	120406716(NR3C2)

ACS:	100566367(nr3c2)

PVT:	110073618(NR3C2)

SUND:

121930435(NR3C2)

PBI:	103066436(NR3C2)

PMUR:

114922595

CTIG:

120313591(NR3C2)

TSR:	106548648(NR3C2)

PGUT:

117680248(NR3C2)

APRI:

131202999(NR3C2)

PTEX:

113434754(NR3C2)

NSS:	113412869(NR3C2)

VKO:	123023768(NR3C2)

PMUA:

114604751(NR3C2)

PRAF:

128421004(NR3C2)

ZVI:	118084503(NR3C2)

HCG:	128326930(NR3C2)

GJA:	107116535(NR3C2)

STOW:

125439842(NR3C2)

EMC:	129336548(NR3C2)

XLA:	108706664(nr3c2.S) 399290(nr3c2.L)

XTR:	100487449(nr3c2)

NPR:	108785218(NR3C2)

RTEM:

120919630(NR3C2)

BBUF:

120990029(NR3C2)

BGAR:

122942989(NR3C2)

MUO:	115461665(NR3C2)

GSH:	117358792(NR3C2)

DRE:	562171(nr3c2)

SRX:	107734552(nr3c2) 107742541

SANH:

SGH:

CCAR:

CAUA:

CGIB:

PTET:

122346212(nr3c2)

LROH:

127169689(nr3c2)

OMC:	131535913(nr3c2)

PPRM:

120492754 120492781(nr3c2)

MAMB:

125272092(nr3c2)

CIDE:

127514765

MASI:

127443881 127445462

TROS:

130552352(nr3c2)

MANU:

129444431(nr3c2)

IPU:

108263320

IFU:	128606084(nr3c2)

PHYP:

113538995(nr3c2)

SMEO:

124375282(nr3c2)

TFD:	113662681(nr3c2)

AMEX:

103045817(nr3c2)

CMAO:

118810832(nr3c2)

EEE:	113589544(nr3c2)

CHAR:

105903549(nr3c2)

TRU:	101068934(nr3c2)

TFS:	130527780(nr3c2)

TNG:	GSTEN00032894G001

LCO:	104917971(nr3c2)

NCC:	104949230(nr3c2)

CGOB:

115011464(nr3c2)

ELY:	117255415(nr3c2)

EFO:	125886272(nr3c2)

PLEP:

121941668(nr3c2)

SLUC:

116034403(nr3c2)

ECRA:

117935437(nr3c2)

ESP:	116705683(nr3c2)

PFLV:

114546234(nr3c2)

GAT:	120825252(nr3c2)

PPUG:

119217472(nr3c2)

AFB:	129096150(nr3c2)

CLUM:

117735531(nr3c2)

MSAM:

119898848(nr3c2)

SCHU:

122873414(nr3c2)

CUD:	121508093(nr3c2)

ALAT:

119025284(nr3c2)

MZE:	101466971(nr3c2)

ONL:	100712208(nr3c2)

OAU:	116330132(nr3c2)

OLA:	100302443(nr3c2)

OML:	112137377(nr3c2)

XMA:	102235678(nr3c2)

XCO:	114144705(nr3c2)

XHE:	116719827(nr3c2)

PRET:

103471378(nr3c2)

PFOR:

103144846(nr3c2)

PLAI:

106962265

PMEI:

106905099

GAF:	122829821(nr3c2)

CVG:	107094929(nr3c2)

CTUL:

119773889

GMU:	124867854(nr3c2)

NFU:	107389617(nr3c2)

KMR:	108230667(nr3c2)

ALIM:

106527549(nr3c2)

NWH:	119422579(nr3c2)

AOCE:

111563254(nr3c2)

MCEP:

125004115(nr3c2)

CSEM:

103383356(nr3c2)

POV:	109638349(nr3c2)

SSEN:

122770676(nr3c2)

HHIP:

117771457(nr3c2)

HSP:	118116318(nr3c2)

LCF:

108893065

SDU:	111216652(nr3c2)

SLAL:

111652930(nr3c2)

XGL:	120799649(nr3c2)

HCQ:	109511363(nr3c2)

SSCV:

125968801

BPEC:

110168794

MALB:

109955522(nr3c2)

BSPL:

114855067(nr3c2)

SASA:

106602364 106610192

STRU:

115191799 115202228

OTW:	112261287 112261291

OMY:	100136210(mra) 100136953(mrb)

OGO:	124001783 124012602

ONE:	115137495 115145597

OKI:	109881008 109901290

OKE:	118361871 118375786

SALP:

111958481

SNH:	120034956 120053049

CCLU:

121536016 123482121

ELS:	105020929(nr3c2)

SFM:	108924478 108936702

PKI:	111833165 111837269(nr3c2)

AANG:

118226724 118231565(nr3c2)

LOC:	102691674(nr3c2)

PSPA:

121296858 121321317(nr3c2)

ARUT:

117409242(nr3c2) 117421141

PSEX:

120527132(nr3c2)

LCM:	102358348(NR3C2)

CMK:	103185495(nr3c2)

RTP:

109934659

CPLA:

122554435(nr3c2)

LERI:

129703866(nr3c2)

DFR:

124490239

» show all

Reference

PMID:3037703

Authors

Arriza JL, Weinberger C, Cerelli G, Glaser TM, Handelin BL, Housman DE, Evans RM

Title

Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor.

Journal

Science 237:268-75 (1987)
DOI:10.1126/science.3037703

Sequence

[hsa:4306]

LinkDB

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