| Entry |
|
|---|
| Name |
Clofarabine (JAN/USAN/INN);
Clolar (TN)
|
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C10H11ClFN5O3
|
|---|
| Exact mass |
303.0534
|
|---|
| Mol weight |
303.6774
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antineoplastic
DG01958 Nucleic acid derivative, antineoplastic
DG01439 Arabinofuranosyl type antineoplastic
DG01439 Arabinofuranosyl type antineoplastic
DG02018 Antimetabolite
DG01958 Nucleic acid derivative, antineoplastic
DG01439 Arabinofuranosyl type antineoplastic
|
|---|
| Remark |
| Therapeutic category: | 4229 |
|
|---|
| Efficacy |
Antineoplastic, Antimetabolite |
|---|
| Disease |
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01B ANTIMETABOLITES
L01BB Purine analogues
L01BB06 Clofarabine
D03546 Clofarabine (JAN/USAN/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
42 Antineoplastics
422 Antimetabolites
4229 Others
D03546 Clofarabine (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Ribonucleoside-diphosphate reductase
RRM1
D03546 Clofarabine (JAN/USAN/INN) <JP/US>
Transferases (EC2)
DNA polymerase
POLA
D03546 Clofarabine (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D03546
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D03546
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D03546
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D03546
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|---|
| Other DBs |
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|---|
| LinkDB |
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|---|
| KCF data |
ATOM 20
1 C1y C 23.0884 -19.5314
2 C1y C 24.4740 -19.5314
3 C1y C 24.9021 -18.2136
4 O2x O 23.7812 -17.3992
5 C1y C 22.6603 -18.2136
6 N5x N 27.3020 -19.5991
7 C8y C 27.3020 -18.2136
8 N4y N 26.1021 -17.5208
9 C1b C 21.4603 -17.5208
10 O1a O 20.2604 -18.2136
11 X F 25.2884 -20.6523
12 O1a O 22.2740 -20.6523
13 C8y C 28.5019 -20.2919
14 N5x N 29.7019 -19.5991
15 C8y C 29.7019 -18.2136
16 C8y C 28.5019 -17.5208
17 C8x C 26.5178 -16.1371
18 N5x N 28.0862 -16.1367
19 X Cl 28.5019 -21.6790
20 N1a N 30.9035 -17.5196
BOND 22
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 1 5 1
6 6 7 1
7 7 8 1
8 3 8 1 #Up
9 5 9 1 #Up
10 9 10 1
11 2 11 1 #Up
12 1 12 1 #Down
13 6 13 2
14 13 14 1
15 14 15 2
16 15 16 1
17 7 16 2
18 8 17 1
19 16 18 1
20 17 18 2
21 13 19 1
22 15 20 1
|
|---|
