KEGG   DRUG: ClofarabineHelp
Entry
D03546                      Drug                                   

Name
Clofarabine (JAN/USAN/INN);
Clolar (TN)
Product
  Generic
Formula
C10H11ClFN5O3
Exact mass
303.0534
Mol weight
303.6774
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antineoplastic
 DG01958  Nucleic acid derivative, antineoplastic
  DG01439  Arabinofuranosyl type antineoplastic
 DG01439  Arabinofuranosyl type antineoplastic
 DG02018  Antimetabolite
  DG01958  Nucleic acid derivative, antineoplastic
   DG01439  Arabinofuranosyl type antineoplastic
Remark
Therapeutic category: 4229
ATC code: L01BB06
Product: D03546<JP/US>
Efficacy
Antineoplastic, Antimetabolite
  Disease
Acute myelogenous leukemia [DS:H00001 H00002]
Acute lymphoblastic leukemia [DS:H00001 H00002]
Target
RRM1 [HSA:6240] [KO:K10807]
POLA [HSA:5422 23649] [KO:K02320 K02321]
  Pathway
hsa00230  Purine metabolism
hsa00240  Pyrimidine metabolism
hsa03030  DNA replication
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01B ANTIMETABOLITES
    L01BB Purine analogues
     L01BB06 Clofarabine
      D03546  Clofarabine (JAN/USAN/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   422  Antimetabolites
    4229  Others
     D03546  Clofarabine (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Ribonucleoside-diphosphate reductase
    RRM1
     D03546  Clofarabine (JAN/USAN/INN) <JP/US>
  Transferases (EC2)
   DNA polymerase
    POLA
     D03546  Clofarabine (JAN/USAN/INN) <JP/US>
Antineoplastics [br08340.html]
 D03546
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D03546
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03546
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03546
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D03546
BRITE hierarchy
Other DBs
CAS: 123318-82-1
PubChem: 47205855
ChEBI: 681569
ChEMBL: CHEMBL1750
DrugBank: DB00631
PDB-CCD: CFB[PDBj]
LigandBox: D03546
NIKKAJI: J457.798A
LinkDB All DBs
KCF data Show

ATOM        20
            1   C1y C    23.0884  -19.5314
            2   C1y C    24.4740  -19.5314
            3   C1y C    24.9021  -18.2136
            4   O2x O    23.7812  -17.3992
            5   C1y C    22.6603  -18.2136
            6   N5x N    27.3020  -19.5991
            7   C8y C    27.3020  -18.2136
            8   N4y N    26.1021  -17.5208
            9   C1b C    21.4603  -17.5208
            10  O1a O    20.2604  -18.2136
            11  X   F    25.2884  -20.6523
            12  O1a O    22.2740  -20.6523
            13  C8y C    28.5019  -20.2919
            14  N5x N    29.7019  -19.5991
            15  C8y C    29.7019  -18.2136
            16  C8y C    28.5019  -17.5208
            17  C8x C    26.5178  -16.1371
            18  N5x N    28.0862  -16.1367
            19  X   Cl   28.5019  -21.6790
            20  N1a N    30.9035  -17.5196
BOND        22
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     6   7 1
            7     7   8 1
            8     3   8 1 #Up
            9     5   9 1 #Up
            10    9  10 1
            11    2  11 1 #Up
            12    1  12 1 #Down
            13    6  13 2
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17    7  16 2
            18    8  17 1
            19   16  18 1
            20   17  18 2
            21   13  19 1
            22   15  20 1

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