Homo sapiens (human): 5422
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Entry
5422 CDS
T01001
Symbol
POLA1, NSX, PDR, POLA, VEODS, p180
Name
(RefSeq) DNA polymerase alpha 1, catalytic subunit
KO
K02320
DNA polymerase alpha subunit A [EC:
2.7.7.7
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa03030
DNA replication
Network
nt06509
DNA replication
Element
N01471
Origin unwinding and elongation
Disease
H00658
X-linked syndromic intellectual developmental disorder
H02484
X-linked reticulate pigmentary disorder with systemic manifestations
Drug target
Clofarabine:
D03546
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09124 Replication and repair
03030 DNA replication
5422 (POLA1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03032 DNA replication proteins [BR:
hsa03032
]
5422 (POLA1)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.7 Nucleotidyltransferases
2.7.7.7 DNA-directed DNA polymerase
5422 (POLA1)
DNA replication proteins [BR:
hsa03032
]
Eukaryotic type
DNA Replication Elongation Factors
DNA polymerase alpha / primase complex
5422 (POLA1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DNA_pol_B
zf-DNA_Pol
DNA_pol_B_exo1
DNA_pol_alpha_N
DNA_pol_B_2
DUF1744
MTR4_beta-barrel
Motif
Other DBs
NCBI-GeneID:
5422
NCBI-ProteinID:
NP_058633
OMIM:
312040
HGNC:
9173
Ensembl:
ENSG00000101868
UniProt:
P09884
Structure
PDB
PDBj
LinkDB
All DBs
Position
X:24693918..24996986
Genome browser
AA seq
1462 aa
AA seq
DB search
MAPVHGDDSLSDSGSFVSSRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDFTGVYEE
VDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDADEKGKDGKARNKDK
RNVKKLAVTKPNNIKSMFIACAGKKTADKAVDLSKDGLLGDILQDLNTETPQITPPPVMI
LKKKRSIGASPNPFSVHTATAVPSGKIASPVSRKEPPLTPVPLKRAEFAGDDVQVESTEE
EQESGAMEFEDGDFDEPMEVEEVDLEPMAAKAWDKESEPAEEVKQEADSGKGTVSYLGSF
LPDVSCWDIDQEGDSSFSVQEVQVDSSHLPLVKGADEEQVFHFYWLDAYEDQYNQPGVVF
LFGKVWIESAETHVSCCVMVKNIERTLYFLPREMKIDLNTGKETGTPISMKDVYEEFDEK
IATKYKIMKFKSKPVEKNYAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTN
TSSLELFLMNRKIKGPCWLEVKSPQLLNQPVSWCKVEAMALKPDLVNVIKDVSPPPLVVM
AFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVSKPKDCIFPYAFKE
VIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWS
KIGRLKRSNMPKLGGRSGFGERNATCGRMICDVEISAKELIRCKSYHLSELVQQILKTER
VVIPMENIQNMYSESSQLLYLLEHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTL
MGGRSERNEFLLLHAFYENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKAAYA
GGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVASEAQKVTEDGEQEQIPE
LPDPSLEMGILPREIRKLVERRKQVKQLMKQQDLNPDLILQYDIRQKALKLTANSMYGCL
GFSYSRFYAKPLAALVTYKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFK
LGNKVKSEVNKLYKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIV
RRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALT
KDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQK
QDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIATWLGLDPTQFRVHHYHKDEENDAL
LGGPAQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKASPL
TFTVQLSNKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQ
PEYSDKSLYTQLCFYRYIFDAECALEKLTTDHEKDKLKKQFFTPKVLQDYRKLKNTAEQF
LSRSGYSEVNLSKLFAGCAVKS
NT seq
4389 nt
NT seq
+upstream
nt +downstream
nt
atggcacctgtgcacggcgacgactctctgtcagattcagggagttttgtatcttctcga
gcccggcgagaaaaaaaatcaaagaaggggcgccaagaagccctagaaagactgaaaaag
gctaaagctggtgagaagtataaatatgaagtcgaggacttcacaggtgtttatgaagaa
gttgatgaagaacagtattcgaagctggttcaggcacgccaggatgatgactggattgtg
gatgatgatggtattggctatgtggaagatggccgagagatttttgatgatgaccttgaa
gatgatgcccttgatgctgatgagaaaggaaaagatggtaaagcacgcaataaagacaag
aggaatgtaaagaagctcgcagtgacaaaaccgaacaacattaagtcaatgttcattgct
tgtgctggaaagaaaactgcagataaagctgtagacttgtccaaggatggtctgctaggt
gacattctacaggatcttaacactgagacacctcaaataactccaccacctgtaatgata
ctgaagaagaaaagatccattggagcttcaccgaatcctttctctgtgcacaccgccacg
gcagttccttcaggaaaaattgcttcccctgtctccagaaaggagcctccattaactcct
gttcctcttaaacgtgctgaatttgctggcgatgatgtacaggtcgagagtacagaagaa
gagcaggagtcaggggcaatggagtttgaagatggtgactttgatgagcccatggaagtt
gaagaggtggacctggagcctatggctgccaaggcttgggacaaagagagtgagccagca
gaggaagtgaaacaagaggcggattctgggaaagggaccgtgtcctacttaggaagtttt
ctcccggatgtctcttgttgggacattgatcaagaaggtgatagcagtttctcagtgcaa
gaagttcaagtggattccagtcacctcccattggtaaaaggggcagatgaggaacaagta
ttccacttttattggttggatgcttatgaggatcagtacaaccaaccaggtgtggtattt
ctgtttgggaaagtttggattgaatcagccgagacccatgtgagctgttgtgtcatggtg
aaaaatatcgagcgaacgctttacttccttccccgtgaaatgaaaattgatctaaatacg
gggaaagaaacaggaactccaatttcaatgaaggatgtttatgaggaatttgatgagaaa
atagcaacaaaatataaaattatgaagttcaagtctaagccagtggaaaagaactatgct
tttgagatacctgatgttccagaaaaatctgagtacttggaagttaaatactcggctgaa
atgccacagcttcctcaagatttgaaaggagaaactttttctcatgtatttgggaccaac
acatctagcctggaactgttcttgatgaacagaaagatcaaaggaccttgttggcttgaa
gtaaaaagtccacagctcttgaatcagccagtcagttggtgtaaagttgaggcaatggct
ttgaaaccagacctggtgaatgtaattaaggatgtcagtccaccaccgcttgtcgtgatg
gctttcagcatgaagacaatgcagaatgcaaagaaccatcaaaatgagattattgctatg
gcagctttggtccatcacagttttgcattggataaagcagccccaaagcctccctttcag
tcacacttctgtgttgtgtctaaaccaaaggactgtatttttccatatgctttcaaagaa
gtcattgagaaaaagaatgtgaaggttgaggttgctgcaacagaaagaacactgctaggt
tttttccttgcaaaagttcacaaaattgatcctgatatcattgtgggtcataatatttat
gggtttgaactggaagtactactgcagagaattaatgtgtgcaaagctcctcactggtcc
aagataggtcgactgaagcgatccaacatgccaaagcttgggggccggagtggatttggt
gaaagaaatgctacctgtggtcgaatgatctgtgatgtggaaatttcagcaaaggaattg
attcgttgtaaaagctaccatctgtctgaacttgttcagcagattctaaaaactgaaagg
gttgtaatcccaatggaaaatatacaaaatatgtacagtgaatcttctcaactgttatac
ctgttggaacacacctggaaagatgccaagttcattttgcagatcatgtgtgagctaaat
gttcttccattagcattgcagatcactaacatcgctgggaacattatgtccaggacgctg
atgggtggacgatccgagcgtaacgagttcttgttgcttcatgcattttacgaaaacaac
tatattgtgcctgacaagcagattttcagaaagcctcagcaaaaactgggagatgaagat
gaagaaattgatggagataccaataaatacaagaaaggacgtaagaaagcagcttatgct
ggaggcttggttttggaccccaaagttggtttttatgataagttcattttgcttctggac
ttcaacagtctatatccttccatcattcaggaatttaacatttgttttacaacagtacaa
agagttgcttcagaggcacagaaagttacagaggatggagaacaagaacagatccctgag
ttgccagatccaagcttagaaatgggcattttgcccagagagatccggaaactggtagaa
cggagaaaacaagtcaaacagctaatgaaacagcaagacttaaatccagaccttattctt
cagtatgacattcgacagaaggctttgaagctcacagcgaacagtatgtatggttgcctg
ggattttcctatagcagattttacgccaaaccactggctgccttggtgacatacaaagga
agggagattttgatgcatacgaaagagatggtacaaaagatgaatcttgaagttatttat
ggagatacagattcaattatgataaacaccaatagcaccaatctggaagaagtatttaag
ttgggaaacaaggtaaaaagtgaagtgaataagttgtacaaactgcttgaaatagacatt
gatggggttttcaagtctctgctactgctgaaaaaaaagaagtacgctgctctggttgtt
gagccaacgtcggatgggaattatgtcaccaaacaggagctcaaaggattagatatagtt
agaagagattggtgtgatcttgctaaagacactggaaactttgtgattggccagattctt
tctgatcaaagccgggacactatagtggaaaacattcagaagaggctgatagaaattgga
gaaaatgtgctaaatggcagtgtcccagtgagccagtttgaaattaacaaggcattgaca
aaggatccccaggattaccctgataaaaaaagcctacctcatgtacatgttgccctctgg
ataaattctcaaggaggcagaaaggtgaaagctggagatactgtgtcatatgtcatctgt
caggatggatcaaacctcactgcaagtcagagggcctatgcgcctgagcagctgcagaaa
caggataatctaaccattgacacccagtactacctggcccagcagatccacccagtcgtg
gctcggatctgtgaaccaatagacggaattgatgctgtcctcattgcaacgtggttggga
cttgaccccacccaatttagagttcatcattatcataaagatgaagagaatgatgctcta
cttggtggcccagcacagctcactgatgaagagaaatacagggactgtgaaagattcaaa
tgtccatgccctacatgtggaactgagaatatttatgataatgtctttgatggttcggga
acagatatggagcccagcttgtatcgttgcagtaacatcgattgtaaggcttcacctctg
acctttacagtacaactgagcaacaaattgatcatggacattagacgtttcattaaaaag
tactatgatggctggttgatatgtgaagagccaacctgtcgcaatcgaactcgtcacctt
ccccttcaattctcccgaactgggcctctttgcccagcctgcatgaaagctacacttcaa
ccagagtattctgacaagtccctgtacacccagctgtgcttttaccggtacatttttgat
gcggagtgtgcactggagaaacttactaccgatcatgagaaagataaattgaagaagcaa
ttttttacccccaaagttctgcaggactacagaaaactcaagaacacagcagagcaattc
ttgtcccgaagtggctactccgaagtgaatctgagcaaactcttcgctggttgtgccgtg
aaatcctaa
DBGET
integrated database retrieval system
