| Entry |
|
|---|
| Name |
Dextromethorphan hydrobromide (USP);
Dextromethorphan hydrobromide hydrate (JP18);
Benylin DM (TN) |
|---|
| Formula |
C18H25NO. HBr. H2O
|
|---|
| Exact mass |
369.1303
|
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| Mol weight |
370.32
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Neuropsychiatric agent
DG01498 NMDA receptor antagonist
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
|---|
| Remark |
| Therapeutic category: | 2223 |
| Product (DG01078): | D00848<JP> |
| Product (mixture): | D04340<JP> D10208<US> D11647<US> D11854<US> D12493<US> |
|
|---|
| Efficacy |
Antitussive |
|---|
| Comment |
Opium alkaloid, morhinan, nonnarcotic
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07235 | N-Methyl-D-aspartic acid (NMDA) receptor antagonists |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R05 COUGH AND COLD PREPARATIONS
R05D COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS
R05DA Opium alkaloids and derivatives
R05DA09 Dextromethorphan
D00848 Dextromethorphan hydrobromide (USP) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
22 Respiratory organ agents
222 Antitussives
2223 Dextromethorphans
D00848 Dextromethorphan hydrobromide (USP); Dextromethorphan hydrobromide hydrate (JP18)
Classification of Japanese OTC drugs [BR:br08313]
Agents for respiratory organs
26 Antitussives and expectorants
D00848 Dextromethorphan hydrobromide (USP)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Dextromethorphan
D00848 Dextromethorphan hydrobromide (USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01498 NMDA receptor antagonist
DG01078 Dextromethorphan
D00848 Dextromethorphan hydrobromide
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01078 Dextromethorphan
D00848 Dextromethorphan hydrobromide
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
Glutamate (ionotropic), NMDA
GRIN (NMDAR)
D00848 Dextromethorphan hydrobromide (USP) <JP>
Transporters
Other transporters
Auxiliary transport proteins (TC:8.A)
SIGMAR1
D00848 Dextromethorphan hydrobromide (USP) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00848 Dextromethorphan hydrobromide hydrate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00848
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01498 NMDA receptor antagonist
DG01078 Dextromethorphan
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01078 Dextromethorphan
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 22
1 O0 O 34.7054 -15.2068
2 X Br 34.2524 -13.3741
3 C1x C 24.6400 -15.4000
4 C1x C 24.6400 -16.8000
5 C1x C 25.8524 -17.5000
6 C1x C 27.0649 -16.8000
7 C1y C 27.0649 -15.4000
8 C1z C 25.8524 -14.7000
9 C1y C 28.2773 -14.7000
10 C1x C 28.2773 -13.3000
11 C8y C 27.0649 -12.6000
12 C8y C 25.8524 -13.3000
13 C8x C 27.0649 -11.2000
14 C8x C 25.8524 -10.5000
15 C8y C 24.6400 -11.2000
16 C8x C 24.6400 -12.6000
17 O2a O 23.4276 -10.5000
18 C1a C 22.2321 -11.1904
19 C1x C 27.0649 -14.0000
20 N1y N 29.4918 -15.4012
21 C1x C 29.4918 -14.0012
22 C1a C 30.8918 -15.4012
BOND 23
1 3 4 1
2 4 5 1
3 5 6 1
4 6 7 1
5 7 8 1
6 3 8 1
7 7 9 1
8 9 10 1
9 10 11 1
10 11 12 2
11 8 12 1
12 11 13 1
13 13 14 2
14 14 15 1
15 15 16 2
16 12 16 1
17 15 17 1
18 17 18 1
19 8 19 1 #Down
20 9 20 1 #Down
21 20 21 1
22 21 19 1
23 20 22 1
|
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