KEGG   DRUG: DienogestHelp
Entry
D03799                      Drug                                   

Name
Dienogest (JAN/USAN/INN);
Endometrion (TN)
Formula
C20H25NO2
Exact mass
311.1885
Mol weight
311.418
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Other
 DG01666  Progesterone receptor agonist
 DG02004  Progesterone
Enzyme substrate
 DG01633  CYP3A substrate
Remark
Therapeutic category: 2499
ATC code: G03DB08
Product: D03799<JP>
Product (mixture): D10461<US>
Efficacy
Anti-endometriosis, Contraceptive, Replenisher (progesterone), Progesterone receptor agonist
Comment
Pregnadiene derivative
Target
NR3C3 (PGR) [HSA:5241] [KO:K08556]
  Pathway
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03D PROGESTOGENS
    G03DB Pregnadien derivatives
     G03DB08 Dienogest
      D03799  Dienogest (JAN/USAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2499  Others
     D03799  Dienogest (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C3 (PGR)
     D03799  Dienogest (JAN/USAN/INN) <JP>
Drug classes of therapeutic agents [br08360.html]
 Endocrine and hormonal agents
  D03799
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03799
BRITE hierarchy
Other DBs
CAS: 65928-58-7
PubChem: 17397887
ChEBI: 70708
ChEMBL: CHEMBL1201864
LigandBox: D03799
NIKKAJI: J23.763I
LinkDB All DBs
KCF data Show

ATOM        23
            1   C2y C    21.9420  -17.7494
            2   C1y C    23.0600  -18.4480
            3   C1x C    21.9420  -16.3519
            4   C2y C    20.6843  -18.4480
            5   C1y C    24.3178  -17.7494
            6   C1x C    23.0600  -19.7757
            7   C1x C    23.1299  -15.7230
            8   C2y C    20.6843  -19.7757
            9   C1x C    19.5664  -17.7494
            10  C1z C    24.3177  -16.4217
            11  C1x C    21.8722  -20.4744
            12  C2x C    19.5664  -20.4744
            13  C1x C    18.3785  -18.4480
            14  C5x C    18.3785  -19.7757
            15  O5x O    17.1906  -20.4744
            16  C1a C    24.3177  -14.7448
            17  C1x C    26.6235  -17.7494
            18  C1x C    26.6235  -16.4217
            19  C1z C    25.5055  -15.7929
            20  O1a O    25.5055  -14.1853
            21  C1b C    26.7168  -15.0936
            22  C3b C    28.1155  -15.0936
            23  N3a N    29.5155  -15.0936
BOND        26
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   6 1
            5     3   7 1
            6     4   8 1
            7     4   9 1
            8     6  11 1
            9     8  12 2
            10    9  13 1
            11   12  14 1
            12   14  15 2
            13    7  10 1
            14    8  11 1
            15   13  14 1
            16   10  16 1 #Up
            17   17  18 1
            18   18  19 1
            19   10  19 1
            20   19  20 1 #Up
            21    5  10 1
            22    5  17 1
            23    2   5 1
            24   19  21 1 #Down
            25   21  22 1
            26   22  23 3

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