KEGG   DRUG: Dimethyl fumarateHelp
Entry
D03846                      Drug                                   

Name
Dimethyl fumarate (JAN/USAN);
Tecfidera (TN)
Product
Formula
C6H8O4
Exact mass
144.0423
Mol weight
144.1253
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Remark
Therapeutic category: 1190
ATC code: N07XX09
Product: D03846<JP/US>
Efficacy
Immunomodulator
  Disease
Multiple sclerosis [DS:H01490]
Target
KEAP1 [HSA:9817] [KO:K10456]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07X OTHER NERVOUS SYSTEM DRUGS
    N07XX Other nervous system drugs
     N07XX09 Dimethyl fumarate
      D03846  Dimethyl fumarate (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Multiple Sclerosis Agents
   Dimethyl fumarate
    D03846  Dimethyl fumarate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D03846  Dimethyl fumarate (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Cellular components
   Ubiquitin system
    KEAP1
     D03846  Dimethyl fumarate (JAN/USAN) <JP/US>
Drug classes of therapeutic agents [br08360.html]
 Neurological agents
  D03846
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D03846
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03846
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03846
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D03846
BRITE hierarchy
Other DBs
CAS: 624-49-7
PubChem: 17397932
ChEBI: 76004
ChEMBL: CHEMBL2107333
LigandBox: D03846
NIKKAJI: J45.019G
LinkDB All DBs
KCF data Show

ATOM        10
            1   C7a C    19.9506  -16.6590
            2   C2b C    21.1616  -17.3610
            3   O7a O    18.7397  -17.3610
            4   O6a O    19.9506  -15.2609
            5   C2b C    22.3784  -16.6590
            6   C7a C    23.5894  -17.3610
            7   O7a O    24.8003  -16.6590
            8   O6a O    23.5894  -18.7591
            9   C1a C    25.9991  -17.3484
            10  C1a C    17.5409  -16.6716
BOND        9
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 2
            5     5   6 1
            6     6   7 1
            7     6   8 2
            8     7   9 1
            9     3  10 1

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