KEGG   DRUG: Ecallantide
Entry
D03931                      Drug                                   
Name
Ecallantide (USAN/INN);
Ecallantide (genetical recombination) (JAN);
Kalbitor (TN)
Product
KALBITOR (Takeda Pharmaceuticals America)
Formula
C305H442N88O91S8
Exact mass
7049.043
Mol weight
7053.828
Sequence
EAMHSFCAFK ADDGPCRAAH PRWFFNIFTR QCEEFIYGGC EGNQNRFESL EECKKMCTRD
(Disulfide bridge: 7-57, 16-40, 32-53)
  Type
Peptide
Remark
ATC code: B06AC03
Product: D03931<US>
Efficacy
Plasma kallikrein inhibitor
  Disease
Hereditary angioedema [DS:H01006]
Comment
Treatment of hereditary angioedema, Reduction of blood loss during cardiothoracic surgery [plasma kallikrein inhibitor]
Target
KLKB1 [HSA:3818] [KO:K01324]
  Pathway
hsa04610  Complement and coagulation cascades
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B06 OTHER HEMATOLOGICAL AGENTS
   B06A OTHER HEMATOLOGICAL AGENTS
    B06AC Drugs used in hereditary angioedema
     B06AC03 Ecallantide
      D03931  Ecallantide (USAN/INN) <US>
USP drug classification [BR:br08302]
 Immunological Agents
  Angioedema Agents
   Kallikrein Inhibitors
    Ecallantide
     D03931  Ecallantide (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Serine peptidases
    KLKB1
     D03931  Ecallantide (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D03931
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D03931
Other DBs
CAS: 460738-38-9
PubChem: 47205919
LinkDB

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