Homo sapiens (human): 3818
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Entry
3818 CDS
T01001
Symbol
KLKB1, KLK3, PKK, PKKD, PPK
Name
(RefSeq) kallikrein B1
KO
K01324
plasma kallikrein [EC:
3.4.21.34
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04610
Complement and coagulation cascades
Network
nt06514
Coagulation cascade
Element
N01516
Kallikrein-kinin system, prekallikrein activation
Disease
H01078
Fletcher factor deficiency
Drug target
Berotralstat (
DG03079
):
D11673
D11674
<JP/US>
Conestat alfa:
D10845
<US>
Ecallantide:
D03931
<US>
Gabexate (
DG01400
):
D01672
<JP>
D08004
Lanadelumab:
D11094
<JP/US>
Sebetralstat:
D12396
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09151 Immune system
04610 Complement and coagulation cascades
3818 (KLKB1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
3818 (KLKB1)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.21 Serine endopeptidases
3.4.21.34 plasma kallikrein
3818 (KLKB1)
Peptidases and inhibitors [BR:
hsa01002
]
Serine peptidases
Family S1: chymotrypsin family
3818 (KLKB1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Trypsin
PAN_1
PAN_4
Trypsin_2
DUF1986
PAN_2
Motif
Other DBs
NCBI-GeneID:
3818
NCBI-ProteinID:
NP_000883
OMIM:
229000
HGNC:
6371
Ensembl:
ENSG00000164344
Pharos:
P03952
(Tclin)
CPD:
C01715
UniProt:
P03952
A8K9A9
Structure
PDB
LinkDB
All DBs
Position
4:186210853..186258471
Genome browser
AA seq
638 aa
AA seq
DB search
MILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLF
SFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVD
MRGVNFNVSKVSSVEECQKRCTSNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIK
VLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFF
TFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGV
DFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRI
AYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCG
GSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEG
NHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNI
PLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGE
GCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
NT seq
1917 nt
NT seq
+upstream
nt +downstream
nt
atgattttattcaagcaagcaacttatttcatttccttgtttgctacagtttcctgtgga
tgtctgactcaactctatgaaaacgccttcttcagaggtggggatgtagcttccatgtac
accccaaatgcccaatactgccagatgaggtgcacattccacccaaggtgtttgctattc
agttttcttccagcaagttcaatcaatgacatggagaaaaggtttggttgcttcttgaaa
gatagtgttacaggaaccctgccaaaagtacatcgaacaggtgcagtttctggacattcc
ttgaagcaatgtggtcatcaaataagtgcttgccatcgagacatttataaaggagttgat
atgagaggagtcaattttaatgtgtctaaggttagcagtgttgaagaatgccaaaaaagg
tgcaccagtaacattcgctgccagtttttttcatatgccacgcaaacatttcacaaggca
gagtaccggaacaattgcctattaaagtacagtcccggaggaacacctaccgctataaag
gtgctgagtaacgtggaatctggattctcactgaagccctgtgccctttcagaaattggt
tgccacatgaacatcttccagcatcttgcgttctcagatgtggatgttgccagggttctc
actccagatgcttttgtgtgtcggaccatctgcacctatcaccccaactgcctcttcttt
acattctatacaaatgtatggaaaatcgagtcacaaagaaatgtttgtcttcttaaaaca
tctgaaagtggcacaccaagttcctctactcctcaagaaaacaccatatctggatatagc
cttttaacctgcaaaagaactttacctgaaccctgccattctaaaatttacccgggagtt
gactttggaggagaagaattgaatgtgacttttgttaaaggagtgaatgtttgccaagag
acttgcacaaagatgattcgctgtcagtttttcacttattctttactcccagaagactgt
aaggaagagaagtgtaagtgtttcttaagattatctatggatggttctccaactaggatt
gcgtatgggacacaagggagctctggttactctttgagattgtgtaacactggggacaac
tctgtctgcacaacaaaaacaagcacacgcattgttggaggaacaaactcttcttgggga
gagtggccctggcaggtgagcctgcaggtgaagctgacagctcagaggcacctgtgtgga
gggtcactcataggacaccagtgggtcctcactgctgcccactgctttgatgggcttccc
ctgcaggatgtttggcgcatctatagtggcattttaaatctgtcagacattacaaaagat
acacctttctcacaaataaaagagattattattcaccaaaactataaagtctcagaaggg
aatcatgatatcgccttgataaaactccaggctcctttgaattacactgaattccaaaaa
ccaatatgcctaccttccaaaggtgacacaagcacaatttataccaactgttgggtaacc
ggatggggcttctcgaaggagaaaggtgaaatccaaaatattctacaaaaggtaaatatt
cctttggtaacaaatgaagaatgccagaaaagatatcaagattataaaataacccaacgg
atggtctgtgctggctataaagaagggggaaaagatgcttgtaagggagattcaggtggt
cccttagtttgcaaacacaatggaatgtggcgtttggtgggcatcaccagctggggtgaa
ggctgtgcccgcagggagcaacctggtgtctacaccaaagtcgctgagtacatggactgg
attttagagaaaacacagagcagtgatggaaaagctcagatgcagtcaccagcatga
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