KEGG   DRUG: Flordipine
Entry
D04193                      Drug                                   
Name
Flordipine (USAN/INN)
Formula
C26H33F3N2O5
Exact mass
510.2342
Mol weight
510.5458
Structure
Class
Cardiovascular agent
 DG01575  Calcium channel blocker
 DG03231  Antihypertensive
  DG01928  Dihydropyridine calcium channel blocker
Efficacy
Antihypertensive, Calcium channel blocker
Comment
Dihydropyridine derivative
Target
CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Interaction
Brite
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01575  Calcium channel blocker
   D04193  Flordipine
  DG03231  Antihypertensive
   DG01928  Dihydropyridine calcium channel blocker
    D04193  Flordipine
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA1-L
     D04193  Flordipine (USAN/INN)
Other DBs
CAS: 77590-96-6
PubChem: 47206139
ChEBI: 177726
LigandBox: D04193
NIKKAJI: J33.088D
LinkDB
KCF data

ATOM        36
            1   C1y C    31.3181  -17.0259
            2   C8y C    31.3064  -20.3346
            3   C2y C    32.4647  -16.3766
            4   C2y C    30.1713  -16.3766
            5   C8y C    30.1538  -20.9958
            6   C8x C    32.4472  -20.9958
            7   C2y C    32.4647  -15.0542
            8   C7a C    33.6114  -17.0259
            9   C2y C    30.1713  -15.0542
            10  C7a C    29.0362  -17.0259
            11  C8x C    30.1538  -22.3063
            12  C1d C    29.0305  -20.3346
            13  C8x C    32.4472  -22.3063
            14  N1y N    31.3181  -14.3932
            15  C1a C    33.6114  -14.3932
            16  O7a O    34.7465  -16.3766
            17  O6a O    33.6114  -18.3540
            18  C1a C    29.0362  -14.3932
            19  O7a O    27.8954  -16.3766
            20  O6a O    29.0422  -18.2544
            21  C8x C    31.3064  -22.9790
            22  C1b C    35.8814  -17.0259
            23  C1b C    26.7546  -17.0259
            24  C1a C    37.0164  -16.3706
            25  C1a C    25.5287  -16.3081
            26  X   F    27.8180  -19.6346
            27  X   F    29.7556  -19.0908
            28  X   F    28.3454  -21.5098
            29  C1b C    31.3176  -13.0203
            30  C1b C    32.5091  -12.3317
            31  N1y N    32.5087  -10.9203
            32  C1x C    33.6994  -10.2322
            33  C1x C    33.6988   -8.8322
            34  O2x O    32.4861   -8.1327
            35  C1x C    31.2954   -8.8208
            36  C1x C    31.2960  -10.2208
BOND        38
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     4  10 1
            10    5  11 2
            11    5  12 1
            12    6  13 1
            13    7  14 1
            14    7  15 1
            15    8  16 1
            16    8  17 2
            17    9  18 1
            18   10  19 1
            19   10  20 2
            20   11  21 1
            21   16  22 1
            22   19  23 1
            23   22  24 1
            24    9  14 1
            25   13  21 2
            26   23  25 1
            27   12  26 1
            28   12  27 1
            29   12  28 1
            30   14  29 1
            31   29  30 1
            32   30  31 1
            33   31  32 1
            34   32  33 1
            35   33  34 1
            36   34  35 1
            37   35  36 1
            38   31  36 1

» Japanese version   » Back

DBGET integrated database retrieval system