KEGG   DRUG: Floxuridine
Entry
D04197                      Drug                                   

Name
Floxuridine (USP/INN);
FUDR (TN)
Product
  Generic
Formula
C9H11FN2O5
Exact mass
246.0652
Mol weight
246.1924
Structure
Simcomp
Class
Antineoplastic
 DG02018  Antimetabolite, antineoplastic
  DG01958  Nucleic acid derivative, antineoplastic
   DG01935  Fluoropyrimidine antineoplastic
Remark
Same as: C11736
ATC code: L01BC09
Product: D04197<US>
Efficacy
Antineoplastic, Antiviral, Antimetabolite
  Disease
Gastrointestinal adenocarcinoma [DS:H00017 H00018 H00019 H00020]
Target
TYMS [HSA:7298] [KO:K00560]
  Pathway
hsa00240  Pyrimidine metabolism
hsa00670  One carbon pool by folate
Interaction
Structure map
map07041  Antineoplastics - antimetabolic agents
Other map
map00983  Drug metabolism - other enzymes
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01B ANTIMETABOLITES
    L01BC Pyrimidine analogues
     L01BC09 Floxuridine
      D04197  Floxuridine (USP/INN) <US>
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Methyltransferases
    TYMS
     D04197  Floxuridine (USP/INN) <US>
Other DBs
CAS: 50-91-9
PubChem: 47206143
ChEBI: 60761
ChEMBL: CHEMBL917
DrugBank: DB00322
LigandBox: D04197
NIKKAJI: J4.488A
LinkDB
KCF data

ATOM        17
            1   C1y C    20.5100  -17.2900
            2   O2x O    19.3900  -16.5200
            3   C1x C    20.0900  -18.6200
            4   C1y C    18.2700  -17.2900
            5   C1y C    18.6900  -18.6200
            6   C1b C    17.0100  -16.8700
            7   O1a O    17.9200  -19.6700
            8   O1a O    16.0300  -17.7800
            9   N4y N    21.8400  -16.8000
            10  C8x C    21.8400  -15.4000
            11  C8y C    23.0300  -17.5000
            12  N4x N    24.2900  -16.8000
            13  C8y C    24.2900  -15.4000
            14  C8y C    23.0300  -14.7000
            15  X   F    23.0300  -13.3000
            16  O5x O    25.4800  -14.7000
            17  O5x O    23.0300  -18.9000
BOND        18
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     4   6 1 #Up
            6     5   7 1 #Down
            7     6   8 1
            8     4   5 1
            9     1   9 1 #Up
            10   10   9 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14   10  14 2
            15   14  15 1
            16   13  16 2
            17   11  17 2
            18   11   9 1

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