KEGG   DRUG: FloxuridineHelp
Entry
D04197                      Drug                                   

Name
Floxuridine (USP/INN);
FUDR (TN)
Product
  Generic
Formula
C9H11FN2O5
Exact mass
246.0652
Mol weight
246.1924
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antineoplastic
 DG01958  Nucleic acid derivative, antineoplastic
  DG01935  Fluoropyrimidine antineoplastic
 DG01935  Fluoropyrimidine antineoplastic
 DG02018  Antimetabolite
  DG01958  Nucleic acid derivative, antineoplastic
   DG01935  Fluoropyrimidine antineoplastic
Remark
Same as: C11736
Product: D04197<US>
Efficacy
Antineoplastic, Antiviral, Antimetabolite
  Disease
Gastrointestinal adenocarcinoma [DS:H00017 H00018 H00019 H00020]
Target
TYMS [HSA:7298] [KO:K00560]
  Pathway
hsa00240  Pyrimidine metabolism
hsa00670  One carbon pool by folate
Interaction
Drug interaction
Structure map
map07041  Antineoplastics - antimetabolic agents
Other map
map00983  Drug metabolism - other enzymes
Brite
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Methyltransferases
    TYMS
     D04197  Floxuridine (USP/INN) <US>
Antineoplastics [br08340.html]
 D04197
BRITE hierarchy
Other DBs
CAS: 50-91-9
PubChem: 47206143
ChEBI: 60761
ChEMBL: CHEMBL917
DrugBank: DB00322
LigandBox: D04197
NIKKAJI: J4.488A
LinkDB All DBs
KCF data Show

ATOM        17
            1   C1y C    20.5100  -17.2900
            2   O2x O    19.3900  -16.5200
            3   C1x C    20.0900  -18.6200
            4   C1y C    18.2700  -17.2900
            5   C1y C    18.6900  -18.6200
            6   C1b C    17.0100  -16.8700
            7   O1a O    17.9200  -19.6700
            8   O1a O    16.0300  -17.7800
            9   N4y N    21.8400  -16.8000
            10  C8x C    21.8400  -15.4000
            11  C8y C    23.0300  -17.5000
            12  N4x N    24.2900  -16.8000
            13  C8y C    24.2900  -15.4000
            14  C8y C    23.0300  -14.7000
            15  X   F    23.0300  -13.3000
            16  O5x O    25.4800  -14.7000
            17  O5x O    23.0300  -18.9000
BOND        18
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     4   6 1 #Up
            6     5   7 1 #Down
            7     6   8 1
            8     4   5 1
            9     1   9 1 #Up
            10   10   9 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14   10  14 2
            15   14  15 1
            16   13  16 2
            17   11  17 2
            18   11   9 1

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