| Entry |
|
|---|
| Name |
Frovatriptan succinate (USAN);
Frovatriptan succinate hydrate;
Frova (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C14H17N3O. C4H6O4. H2O
|
|---|
| Exact mass |
379.1743
|
|---|
| Mol weight |
379.41
|
|---|
| Structure |
|
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| Class |
|
|---|
| Remark |
| Product (DG00841): | D04264<US> |
|
|---|
| Efficacy |
Antimigraine, Serotonin receptor agonist |
|---|
| Comment |
Sumatriptan derivative
acute treatment of migraine with or without aura
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N02 ANALGESICS
N02C ANTIMIGRAINE PREPARATIONS
N02CC Selective serotonin (5HT1) agonists
N02CC07 Frovatriptan
D04264 Frovatriptan succinate (USAN) <US>
USP drug classification [BR:br08302]
Antimigraine Agents
Serotonin (5-HT) Receptor Agonists
Frovatriptan
D04264 Frovatriptan succinate (USAN)
Drug groups [BR:br08330]
Analgesic
DG01484 5-HT1B-receptor agonist
DG00841 Frovatriptan
D04264 Frovatriptan succinate
DG01485 5-HT1D-receptor agonist
DG00841 Frovatriptan
D04264 Frovatriptan succinate
DG01518 5-HT1B/1D-receptor agonist
DG00841 Frovatriptan
D04264 Frovatriptan succinate
DG01943 Triptan
DG00841 Frovatriptan
D04264 Frovatriptan succinate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Serotonin
HTR1B
D04264 Frovatriptan succinate (USAN) <US>
HTR1D
D04264 Frovatriptan succinate (USAN) <US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D04264
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D04264
Drug groups [BR:br08330]
Analgesic
DG01484 5-HT1B-receptor agonist
DG00841 Frovatriptan
DG01485 5-HT1D-receptor agonist
DG00841 Frovatriptan
DG01518 5-HT1B/1D-receptor agonist
DG00841 Frovatriptan
DG01943 Triptan
DG00841 Frovatriptan
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 27
1 C1y C 10.3600 -17.1500
2 C1x C 10.3600 -18.5500
3 C1x C 11.5500 -19.2500
4 C8y C 12.8100 -18.5500
5 C8y C 12.8100 -17.1500
6 C1x C 11.5500 -16.4500
7 N4x N 14.1400 -18.9700
8 C8y C 14.9100 -17.8500
9 C8y C 14.1400 -16.7300
10 N1b N 9.1700 -16.4500
11 C1a C 7.9800 -17.1500
12 C8x C 16.3100 -17.8500
13 C8x C 17.0100 -16.6600
14 C8y C 16.3100 -15.4700
15 C8x C 14.9100 -15.4700
16 C5a C 17.0100 -14.2800
17 N1a N 18.4100 -14.2800
18 O5a O 16.3100 -13.0900
19 C6a C 26.6700 -15.3300
20 C1b C 25.4800 -16.1000
21 O6a O 27.8600 -16.1000
22 O6a O 26.6700 -13.9300
23 C1b C 24.2200 -15.4000
24 C6a C 23.0300 -16.1000
25 O6a O 21.7700 -15.4000
26 O6a O 23.0300 -17.5000
27 O0 O 26.9500 -18.5500
BOND 27
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 2
5 5 6 1
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 5 9 1
11 1 10 1 #Up
12 10 11 1
13 8 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 15 9 2
18 14 16 1
19 16 17 1
20 16 18 2
21 19 20 1
22 19 21 1
23 19 22 2
24 20 23 1
25 23 24 1
26 24 25 1
27 24 26 2
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