| Entry |
|
|---|
| Name |
Guanethidine monosulfate (USP);
Guanethidine sulfate (JP18);
Ismelin (TN) |
|---|
| Formula |
C10H22N4. H2SO4
|
|---|
| Exact mass |
296.1518
|
|---|
| Mol weight |
296.39
|
|---|
| Structure |
|
|---|
| Class |
Cardiovascular agent
DG01739 Peripherally-acting antiadrenergic
Neuropsychiatric agent
DG03085 Selective norepinephrine reuptake inhibitor (NRI)
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
|
|---|
| Remark |
|
|---|
| Efficacy |
Antihypertensive, Noradrenaline release inhibitor |
|---|
| Comment |
Guanidine derivative
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C02 ANTIHYPERTENSIVES
C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING
C02CC Guanidine derivatives
C02CC02 Guanethidine
D04382 Guanethidine monosulfate (USP)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01EX Other antiglaucoma preparations
S01EX01 Guanethidine
D04382 Guanethidine monosulfate (USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01739 Peripherally-acting antiadrenergic
DG00258 Guanethidine
D04382 Guanethidine monosulfate
Neuropsychiatric agent
DG03085 Selective norepinephrine reuptake inhibitor (NRI)
DG00258 Guanethidine
D04382 Guanethidine monosulfate
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG00258 Guanethidine
D04382 Guanethidine monosulfate
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A2 (NAT1)
D04382 Guanethidine monosulfate (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D04382 Guanethidine sulfate
Drug groups [BR:br08330]
Cardiovascular agent
DG01739 Peripherally-acting antiadrenergic
DG00258 Guanethidine
Neuropsychiatric agent
DG03085 Selective norepinephrine reuptake inhibitor (NRI)
DG00258 Guanethidine
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG00258 Guanethidine
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 19
1 N1y N 21.4998 -15.4594
2 C1b C 20.2881 -14.7604
3 C1x C 21.4998 -16.9041
4 C1x C 22.5250 -14.4341
5 C1b C 19.1231 -15.4594
6 C1x C 22.4784 -17.8828
7 C1x C 23.9230 -14.4341
8 N1b N 17.9581 -14.7604
9 C1x C 23.9230 -17.8828
10 C1x C 24.9017 -15.4128
11 C2c C 16.7464 -15.4594
12 C1x C 24.9017 -16.9041
13 N1a N 15.5813 -14.7604
14 N2a N 16.7464 -16.8109
15 S4a S 30.1701 -16.4848
16 O1d O 30.1701 -15.0862
17 O1d O 30.1701 -17.8833
18 O1d O 31.5686 -16.4848
19 O1d O 28.7716 -16.4848
BOND 18
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1
5 3 6 1
6 4 7 1
7 5 8 1
8 6 9 1
9 7 10 1
10 8 11 1
11 9 12 1
12 11 13 1
13 11 14 2
14 10 12 1
15 15 16 2
16 15 17 2
17 15 18 1
18 15 19 1
|
|---|
