KEGG   DRUG: Insulin detemirHelp
Entry
D04539                      Drug                                   

Name
Insulin detemir (USAN/INN);
Insulin detemir (genetical recombination) (JAN);
Levemir (TN)
Product
Formula
C267H402N64O76S6
Exact mass
5912.7883
Mol weight
5916.822
Sequence
(A chain) Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr
Gln Leu Glu Asn Tyr Cys Asn (Disulfide bridge: 6-11)
(B chain) Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala
Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro
Lys-C14H27O (Disulfide bridge: A7-B7; A20-B19)
  Type
Peptide
Class
Antidiabetic agent
 DG01636  Insulin and analog
  DG01801  Insulin analog
   DG01797  Insulin analog, long-acting
Enzyme inducer
 DG01637  CYP1A2 inducer
Remark
Therapeutic category: 2492
ATC code: A10AE05
Product: D04539<JP/US>
Efficacy
Antidiabetic, Insulin receptor agonist
  Disease
Type II diabetes mellitus [DS:H00409]
Type I diabetes mellitus [DS:H00408]
Maturity onset diabetes of the young [DS:H00410]
Permanent neonatal diabetes mellitus [DS:H00512]
Transient neonatal diabetes mellitus [DS:H00513]
Comment
Insulin analog
Target
INSR (CD220) [HSA:3643] [KO:K04527]
  Pathway
hsa04910  Insulin signaling pathway
hsa04930  Type II diabetes mellitus
Interaction
CYP induction: CYP1A2 [HSA:1544]
Drug interaction
Structure map
map07051  Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10A INSULINS AND ANALOGUES
    A10AE Insulins and analogues for injection, long-acting
     A10AE05 Insulin detemir
      D04539  Insulin detemir (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Insulins
   Insulin detemir
    D04539  Insulin detemir (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2492  Pancreatic hormones
     D04539  Insulin detemir (USAN/INN); Insulin detemir (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   INSR family
    INSR (CD220)
     D04539  Insulin detemir (USAN/INN) <JP/US>
Drug classes of therapeutic agents [br08360.html]
 Antidiabetic agents
  D04539
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D04539
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D04539
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D04539
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D04539
BRITE hierarchy
Other DBs
CAS: 169148-63-4
PubChem: 17398128
NIKKAJI: J2.337.674A
LinkDB All DBs

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