KEGG   ORTHOLOGY: K04527
Entry
K04527                      KO                                     
Symbol
INSR, CD220
Name
insulin receptor [EC:2.7.10.1]
Pathway
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04022  cGMP-PKG signaling pathway
map04066  HIF-1 signaling pathway
map04068  FoxO signaling pathway
map04072  Phospholipase D signaling pathway
map04150  mTOR signaling pathway
map04151  PI3K-Akt signaling pathway
map04152  AMPK signaling pathway
map04211  Longevity regulating pathway
map04212  Longevity regulating pathway - worm
map04213  Longevity regulating pathway - multiple species
map04361  Axon regeneration
map04520  Adherens junction
map04910  Insulin signaling pathway
map04913  Ovarian steroidogenesis
map04923  Regulation of lipolysis in adipocytes
map04930  Type II diabetes mellitus
map04931  Insulin resistance
map04932  Non-alcoholic fatty liver disease
map04960  Aldosterone-regulated sodium reabsorption
map05010  Alzheimer disease
map05415  Diabetic cardiomyopathy
Disease
H00719  Leprechaunism
H00942  Rabson-Mendenhall syndrome
H01228  Insulin-resistant diabetes mellitus with acanthosis nigricans
H01267  Familial hyperinsulinemic hypoglycemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04527  INSR, CD220; insulin receptor
   04014 Ras signaling pathway
    K04527  INSR, CD220; insulin receptor
   04015 Rap1 signaling pathway
    K04527  INSR, CD220; insulin receptor
   04066 HIF-1 signaling pathway
    K04527  INSR, CD220; insulin receptor
   04068 FoxO signaling pathway
    K04527  INSR, CD220; insulin receptor
   04072 Phospholipase D signaling pathway
    K04527  INSR, CD220; insulin receptor
   04022 cGMP-PKG signaling pathway
    K04527  INSR, CD220; insulin receptor
   04151 PI3K-Akt signaling pathway
    K04527  INSR, CD220; insulin receptor
   04152 AMPK signaling pathway
    K04527  INSR, CD220; insulin receptor
   04150 mTOR signaling pathway
    K04527  INSR, CD220; insulin receptor
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04527  INSR, CD220; insulin receptor
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04527  INSR, CD220; insulin receptor
   04923 Regulation of lipolysis in adipocytes
    K04527  INSR, CD220; insulin receptor
   04913 Ovarian steroidogenesis
    K04527  INSR, CD220; insulin receptor
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K04527  INSR, CD220; insulin receptor
  09158 Development and regeneration
   04361 Axon regeneration
    K04527  INSR, CD220; insulin receptor
  09149 Aging
   04211 Longevity regulating pathway
    K04527  INSR, CD220; insulin receptor
   04212 Longevity regulating pathway - worm
    K04527  INSR, CD220; insulin receptor
   04213 Longevity regulating pathway - multiple species
    K04527  INSR, CD220; insulin receptor
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04527  INSR, CD220; insulin receptor
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K04527  INSR, CD220; insulin receptor
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04527  INSR, CD220; insulin receptor
   04932 Non-alcoholic fatty liver disease
    K04527  INSR, CD220; insulin receptor
   04931 Insulin resistance
    K04527  INSR, CD220; insulin receptor
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04527  INSR, CD220; insulin receptor
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K04527  INSR, CD220; insulin receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04527  INSR, CD220; insulin receptor
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  INSR family [OT]
   K04527  INSR, CD220; insulin receptor
CD molecules [BR:ko04090]
 Proteins
  K04527  CD220, INSR; insulin receptor
Other DBs
GO: 0005009
Genes
HSA: 3643(INSR)
PTR: 455649(INSR)
PPS: 100991905(INSR)
GGO: 101144696(INSR)
PON: 100451422(INSR)
NLE: 100597533(INSR)
MCC: 706009(INSR)
MCF: 102139081(INSR)
MTHB: 126942469
CSAB: 103234346(INSR)
CATY: 105589163(INSR)
PANU: 101012351(INSR)
TGE: 112613164(INSR)
RRO: 104679498(INSR)
RBB: 108534554(INSR)
TFN: 117076717(INSR)
PTEH: 111522649(INSR)
CJC: 100403400(INSR)
SBQ: 101028986(INSR)
CSYR: 103273081(INSR)
MMUR: 105869687
LCAT: 123635850(INSR)
OGA: 100962237(INSR)
MMU: 16337(Insr)
MCAL: 110300622(Insr)
MPAH: 110336317(Insr)
RNO: 24954(Insr)
MCOC: 116068825(Insr)
CGE: 100766818(Insr)
MAUA: 121134754 121136483(Insr)
PLEU: 114683184(Insr)
MORG: 121465153(Insr)
MFOT: 126491593
AAMP: 119825604(Insr)
NGI: 103743312(Insr)
HGL: 101722168(Insr)
CPOC: 100718484(Insr)
CCAN: 109694006(Insr)
DORD: 105998714(Insr)
DSP: 122119565(Insr)
NCAR: 124968393
OCU: 100008911(INSR)
OPI: 101530887(INSR)
TUP: 102469167(INSR)
CFA: 484990(INSR)
CLUD: 112666443(INSR)
VVP: 112909702(INSR)
VLG: 121494318(INSR)
AML: 100473956(INSR)
UMR: 103676308(INSR)
UAH: 113242935(INSR)
UAR: 123777569(INSR)
ELK: 111161798
LLV: 125085453
MPUF: 101677072(INSR)
ORO: 101363371(INSR)
EJU: 114200877(INSR)
ZCA: 113916517(INSR)
MLX: 118005442(INSR)
NSU: 110593671(INSR)
FCA: 100127108(INSR)
PYU: 121013826(INSR)
PBG: 122488640(INSR)
LRUF: 124523268
PTG: 102967156(INSR)
PPAD: 109254164(INSR)
AJU: 106979040(INSR)
HHV: 120244875(INSR)
BTA: 408017(INSR)
BOM: 102285317(INSR)
BBUB: 102391024(INSR)
CHX: 102168996(INSR)
OAS: 443431(INSR)
ODA: 120863920(INSR)
CCAD: 122440366(INSR)
SSC: 396755(INSR)
CFR: 102522017(INSR)
CBAI: 105078270(INSR)
CDK: 105087555(INSR)
VPC: 102544508(INSR)
BACU: 103018249(INSR)
LVE: 103085622(INSR)
OOR: 101283355(INSR)
DLE: 111165931(INSR)
PSIU: 116751331(INSR)
ECB: 100066248(INSR)
EAI: 106844524(INSR)
MYB: 102252005(INSR)
MYD: 102766590(INSR)
MMYO: 118659286(INSR)
MLF: 102437355(INSR)
MNA: 107540632(INSR)
PKL: 118725880(INSR)
HAI: 109396062(INSR)
DRO: 112296365(INSR)
SHON: 118987715(INSR)
AJM: 119045329(INSR)
PDIC: 114509225(INSR)
PHAS: 123811181(INSR)
MMF: 118615134(INSR)
RFQ: 117037841(INSR)
PALE: 102879346(INSR)
PGIG: 120599285(INSR)
PVP: 105307438(INSR)
RAY: 107519908(INSR)
MJV: 108404652(INSR)
TOD: 119240421(INSR)
SARA: 101540495(INSR)
LAV: 100668116(INSR)
TMU: 101360415
DNM: 101431970(INSR)
MDO: 100027215(INSR)
GAS: 123256825(INSR)
SHR: 100929204(INSR)
PCW: 110203364(INSR)
OAA: 100079104(INSR)
GGA: 420133(INSR)
PCOC: 116235701(INSR)
MGP: 100550007(INSR)
CJO: 107325585(INSR)
NMEL: 110389023(INSR)
APLA: 101795803(INSR)
ACYG: 106044962(INSR)
AFUL: 116499030(INSR)
TGU: 100228094(INSR)
LSR: 110479633(INSR)
SCAN: 103821923(INSR)
PMOA: 120498117(INSR)
OTC: 121341361(INSR)
PRUF: 121360714(INSR)
GFR: 102036061(INSR)
FAB: 101813861(INSR)
PHI: 102105828(INSR)
PMAJ: 107215564(INSR)
CCAE: 111940344(INSR)
CCW: 104696982(INSR)
CBRC: 103622109(INSR)
ETL: 114069501(INSR)
ZAB: 102069793(INSR)
ACHL: 103800983
FPG: 101914421(INSR)
FCH: 102056291(INSR)
CLV: 102085804(INSR)
EGZ: 104124372(INSR)
NNI: 104018719(INSR)
PLET: 104617295
PCRI: 104033691(INSR)
PCAO: 104046138(INSR)
PADL: 103926439(INSR)
AFOR: 103902914(INSR)
ACHC: 115348898(INSR)
HALD: 104322774(INSR)
CCRI: 104160448(INSR)
CSTI: 104552904(INSR)
EHS: 104512268(INSR)
CMAC: 104478591
MUI: 104542502(INSR)
FGA: 104083384(INSR)
GSTE: 104259893(INSR)
LDI: 104347584(INSR)
MNB: 103769292(INSR)
OHA: 104328943(INSR)
NNT: 104407859(INSR)
DPUB: 104300798(INSR)
PGUU: 104468784(INSR)
ACAR: 104523070(INSR)
CVF: 104295405(INSR)
CUCA: 104060956(INSR)
AAM: 106495607(INSR)
AROW: 112966718(INSR)
NPD: 112943851(INSR)
TGT: 104567607(INSR)
DNE: 112986563(INSR)
SCAM: 104146182(INSR)
ASN: 102378715(INSR)
AMJ: 102558884(INSR)
CPOO: 109312363(INSR)
GGN: 109295003(INSR)
PSS: 102459083(INSR)
CMY: 102935205(INSR)
CPIC: 101947783(INSR)
TST: 117869064
CABI: 116826238(INSR)
MRV: 120391598(INSR)
ACS: 100567954(insr)
PVT: 110072679(INSR)
SUND: 121916648
CTIG: 120305990(INSR)
TSR: 106546257(INSR)
PGUT: 117677421(INSR)
VKO: 123025167(INSR)
PMUA: 114588308(INSR)
ZVI: 118085901(INSR)
GJA: 107121673(INSR)
STOW: 125432863(INSR)
XLA: 100158430(insr.S) 398006(insr.L)
XTR: 100492718(insr)
NPR: 108785893(INSR)
RTEM: 120909484(INSR)
BBUF: 120989403(INSR)
BGAR: 122920525(INSR)
DRE: 245699(insra) 245700(insrb)
CCAR: 109046541
MAMB: 125251149(insra) 125263650(insrb)
IPU: 108267827(insra)
PHYP: 113540093
SMEO: 124388066(insra) 124391139(insrb)
TFD: 113647079(insra) 113650213(insrb)
EEE: 113584152
TRU: 101074083
LCO: 104926189
NCC: 104961264(insr)
CGOB: 115022820
ELY: 117271532(insra)
EFO: 125901820(insra)
PLEP: 121950966(insra)
SLUC: 116045912(insra)
ECRA: 117953563(insra)
ESP: 116698703
PFLV: 114564739
GAT: 120816187(insra)
PPUG: 119209490(insra)
MSAM: 119901871(insra)
CUD: 121520772
ALAT: 119010790(insra)
MZE: 101480309
ONL: 100696191
OAU: 116313412(insra)
OLA: 101166254
OML: 112147354(insra)
XMA: 102238226(insr)
XCO: 114146472(insr)
XHE: 116721171(insr)
PRET: 103479883(insr)
PFOR: 103146076(insr)
PLAI: 106960374(insr)
PMEI: 106916182
GAF: 122841621(insra)
CVG: 107094230(insr)
CTUL: 119787886(insra)
GMU: 124869846(insra)
NFU: 107383587
KMR: 108232893(insra)
ALIM: 106516858(insr)
NWH: 119415203(insra)
AOCE: 111565521(insr)
MCEP: 125010721(insra)
CSEM: 103396460
POV: 109643727
SSEN: 122768741(insra)
HHIP: 117778848(insra)
HSP: 118118019(insra)
LCF: 108884165(insra)
SDU: 111231251
SLAL: 111669127
XGL: 120798578(insra)
HCQ: 109507385
BPEC: 110164155
MALB: 109955317
BSPL: 114844025(insra)
SALP: 111979632
ELS: 105005877
AANG: 118225873(insrb) 118229991
LOC: 102696537(insr)
CMK: 103181967
BFO: 118410612
CIN: 778651
AGA: AgaP_AGAP012424(INR)
ACOZ: 120954824
AARA: 120900258
ASTE: 118508044
CPII: 120422667
AME: 411297 725827(InR-2)
OBB: 114872824
PFUC: 122514871
VPS: 122636656
CGLO: 123269802
DAM: 107036277
AGIF: 122858262
CCIN: 107271782
TCA: 661524(InR)
CSET: 123322429
PPOT: 106108942
PXU: 106121812
ZCE: 119832984
OFU: 114355967
DCI: 103516039
NLU: 111047475
CSEC: 111861850
PCLA: 123763973
PTRU: 123502663
HAZT: 108676308
LSM: 121115991
RMP: 119176517
VDE: 111253591
SDM: 118191077
CEL: CELE_Y55D5A.5(daf-2)
CBR: CBG_15732(Cbr-daf-2)
GAE: 121382752
HRF: 124150084
HRJ: 124255463
CRG: 105348544
OSN: 115209076
NVE: 5519848
ATEN: 116294618
XEN: 124454787
 » show all
Reference
PMID:2859121
  Authors
Ebina Y, Ellis L, Jarnagin K, Edery M, Graf L, Clauser E, Ou JH, Masiarz F, Kan YW, Goldfine ID, et al.
  Title
The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling.
  Journal
Cell 40:747-58 (1985)
DOI:10.1016/0092-8674(85)90334-4
  Sequence
[hsa:3643]
Reference
  Authors
Youngren JF
  Title
Regulation of insulin receptor function.
  Journal
Cell Mol Life Sci 64:873-91 (2007)
DOI:10.1007/s00018-007-6359-9
  Sequence
[rno:24954]
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