KEGG   DRUG: LacidipineHelp
Entry
D04657                      Drug                                   

Name
Lacidipine (USAN/INN);
Motens (TN)
Formula
C26H33NO6
Exact mass
455.2308
Mol weight
455.5433
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01928  Dihydropyridine calcium channel blocker
Other
 DG01575  Calcium channel blocker
  DG01496  Calcium channel L type blocker
Remark
ATC code: C08CA09
Efficacy
Antihypertensive, Calcium channel blocker
Comment
Dihydropyridine derivative
Target
CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Interaction
Drug interaction
Structure map
map07036  Calcium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
    C08CA Dihydropyridine derivatives
     C08CA09 Lacidipine
      D04657  Lacidipine (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA1-L
     D04657  Lacidipine (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 103890-78-4
PubChem: 47206500
ChEMBL: CHEMBL460291
LigandBox: D04657
NIKKAJI: J325.878E
LinkDB All DBs
KCF data Show

ATOM        33
            1   C1y C    30.7658  -15.9980
            2   C8y C    30.8182  -18.2612
            3   C2y C    29.5904  -15.3231
            4   C2y C    31.9409  -15.3290
            5   C8x C    29.6371  -18.9361
            6   C8y C    31.9935  -18.9478
            7   C2y C    29.5963  -13.9617
            8   C7a C    28.4093  -15.9923
            9   C2y C    31.9468  -13.9734
            10  C7a C    33.1104  -16.0096
            11  C8x C    29.6371  -20.2975
            12  C8x C    31.9877  -20.2975
            13  N1x N    30.7715  -13.2868
            14  C1a C    28.4209  -13.2811
            15  O7a O    27.2400  -15.3174
            16  O6a O    28.4093  -17.3594
            17  C1a C    33.1220  -13.2928
            18  O7a O    34.2914  -15.3406
            19  O6a O    33.1046  -17.3710
            20  C8x C    30.8066  -20.9782
            21  C1b C    26.0648  -15.9923
            22  C1b C    35.4667  -16.0212
            23  C1a C    24.8895  -15.3115
            24  C1a C    36.6913  -15.3163
            25  C2b C    33.2154  -18.2501
            26  C2b C    34.3974  -18.9401
            27  C7a C    35.5884  -18.2599
            28  O7a O    36.7621  -18.9450
            29  O6a O    35.5258  -16.8532
            30  C1d C    37.9573  -18.2623
            31  C1a C    39.3583  -17.4419
            32  C1a C    38.6325  -19.4451
            33  C1a C    37.2518  -17.0264
BOND        34
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     4  10 1
            10    5  11 1
            11    6  12 2
            12    7  13 1
            13    7  14 1
            14    8  15 1
            15    8  16 2
            16    9  17 1
            17   10  18 1
            18   10  19 2
            19   11  20 2
            20   15  21 1
            21   18  22 1
            22   21  23 1
            23    9  13 1
            24   12  20 1
            25   22  24 1
            26    6  25 1
            27   25  26 2
            28   26  27 1
            29   27  28 1
            30   27  29 2
            31   28  30 1
            32   30  31 1
            33   30  32 1
            34   30  33 1

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