KEGG   DRUG: Mefloquine
Entry
D04895                      Drug                                   
Name
Mefloquine (USAN/INN)
Formula
C17H16F6N2O
Exact mass
378.1167
Mol weight
378.31
Structure
Simcomp
Class
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
Same as: C07633
ATC code: P01BC02
Chemical structure group: DG01020
Product (DG01020): D00831<JP/US>
Efficacy
Antimalarial
Comment
Methanolquinoline
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Structure map
map07025  Quinolines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 P ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
  P01 ANTIPROTOZOALS
   P01B ANTIMALARIALS
    P01BC Methanolquinolines
     P01BC02 Mefloquine
      D04895  Mefloquine (USAN/INN)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG01020  Mefloquine
    D04895  Mefloquine
Antimicrobials [BR:br08307]
 Antiparasitics
  Antmalarials
   Methanolquinoline
    D04895  Mefloquine (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D04895
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG01020  Mefloquine
Other DBs
CAS: 53230-10-7
PubChem: 47206659
ChEBI: 63609 63681
LigandBox: D04895
NIKKAJI: J244.888B
LinkDB
KCF data

ATOM        26
            1   C8y C    17.5956  -17.6229
            2   C8y C    17.5490  -16.2269
            3   C8y C    16.2989  -18.3064
            4   N5x N    18.7231  -18.3413
            5   C8y C    18.7641  -15.5492
            6   C8x C    16.3457  -15.5024
            7   C8x C    15.0956  -17.5879
            8   C1d C    16.2873  -19.7025
            9   C8y C    19.9440  -17.6580
            10  C8x C    19.9616  -16.2619
            11  C1c C    18.7465  -14.1472
            12  C8x C    15.1130  -16.1801
            13  X   F    14.8853  -19.6966
            14  X   F    17.6833  -19.7025
            15  X   F    16.2756  -21.1045
            16  C1d C    21.1416  -18.3706
            17  C1y C    19.9616  -13.4462
            18  O1a O    17.5315  -13.4519
            19  X   F    22.3450  -19.0717
            20  X   F    21.8308  -17.1555
            21  X   F    20.4348  -19.5798
            22  C1x C    21.1767  -14.1472
            23  N1x N    19.9616  -12.0442
            24  C1x C    22.3916  -13.4402
            25  C1x C    21.1767  -11.3432
            26  C1x C    22.3916  -12.0384
BOND        28
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     5  10 2
            10    5  11 1
            11    6  12 2
            12    8  13 1
            13    8  14 1
            14    8  15 1
            15    9  16 1
            16   11  17 1
            17   11  18 1 #Down
            18   16  19 1
            19   16  20 1
            20   16  21 1
            21   17  22 1
            22   17  23 1
            23   22  24 1
            24   23  25 1
            25   24  26 1
            26    7  12 1
            27    9  10 1
            28   25  26 1

» Japanese version   » Back

KEGG   DRUG: Mefloquine hydrochloride
Entry
D00831                      Drug                                   
Name
Mefloquine hydrochloride (JP18/USP);
Lariam (TN)
Product
  Generic
Formula
C17H16F6N2O. HCl
Exact mass
414.0934
Mol weight
414.77
Structure
Simcomp
Class
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
Therapeutic category: 6419
ATC code: P01BC02
Chemical structure group: DG01020
Product (DG01020): D00831<JP/US>
Efficacy
Antimalarial
  Disease
Malaria [DS:H00361]
Comment
Methanolquinoline
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Structure map
map07025  Quinolines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 P ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
  P01 ANTIPROTOZOALS
   P01B ANTIMALARIALS
    P01BC Methanolquinolines
     P01BC02 Mefloquine
      D00831  Mefloquine hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Antiparasitics
  Antiprotozoals
   Mefloquine
    D00831  Mefloquine hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  64  Parasitics (systemic)
   641  Antiprotozoans
    6419  Others
     D00831  Mefloquine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG01020  Mefloquine
    D00831  Mefloquine hydrochloride
Antimicrobials [BR:br08307]
 Antiparasitics
  Antmalarials
   Methanolquinoline
    D00831  Mefloquine hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00831  Mefloquine hydrochloride
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00831
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00831
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG01020  Mefloquine
Other DBs
CAS: 51773-92-3
PubChem: 7847896
ChEBI: 6719
LigandBox: D00831
NIKKAJI: J299.330I
LinkDB
KCF data

ATOM        27
            1   C8y C    16.2139  -17.5612
            2   C8y C    16.2371  -16.1629
            3   C8y C    14.9852  -18.2456
            4   N5x N    17.4131  -18.2807
            5   C8y C    17.4541  -15.4843
            6   C8x C    15.0321  -15.4375
            7   C8x C    13.7802  -17.5261
            8   C1d C    14.9736  -19.6440
            9   C8y C    18.6359  -17.5963
            10  C8x C    18.6535  -16.1979
            11  C1c C    17.4365  -14.0802
            12  C8x C    13.7975  -16.1162
            13  X   F    13.6395  -19.6381
            14  X   F    16.4419  -19.6440
            15  X   F    14.9619  -21.0481
            16  C1d C    19.8352  -18.3101
            17  C1y C    18.6535  -13.3781
            18  O1a O    16.2197  -13.3838
            19  X   F    21.0405  -19.0121
            20  X   F    20.5256  -17.0931
            21  X   F    19.1274  -19.5211
            22  C1x C    19.8704  -14.0802
            23  N1x N    18.6535  -11.9740
            24  C1x C    21.0874  -13.3721
            25  C1x C    19.8704  -11.2719
            26  C1x C    21.0874  -11.9681
            27  X   Cl   23.6498  -15.1039
BOND        28
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     5  10 2
            10    5  11 1
            11    6  12 2
            12    8  13 1
            13    8  14 1
            14    8  15 1
            15    9  16 1
            16   11  17 1
            17   11  18 1 #Down
            18   16  19 1
            19   16  20 1
            20   16  21 1
            21   17  22 1
            22   17  23 1
            23   22  24 1
            24   23  25 1
            25   24  26 1
            26    7  12 1
            27    9  10 1
            28   25  26 1

» Japanese version   » Back

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