KEGG   DRUG: Metreleptin
Entry
D05014                      Drug                                   
Name
Metreleptin (USAN/INN);
Mettreleptin (genetical recombination) (JAN);
Metreleptin (TN);
Myalept (TN)
Product
Formula
C714H1167N191O221S6
Exact mass
16145.4275
Mol weight
16155.4429
Sequence
MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSSKQKVTGL DFIPGLHPIL TLSKMDQTLA
VYQQILTSMP SRNVIQISND LENLRDLLHV LAFSKSCHLP WASGLETLDS LGGVLEASGY
STEVVALSRL QGSLQDMLWQ LDLSPGC (Disulfide bridge: 97-147)
  Type
Peptide
Remark
Therapeutic category: 2499
ATC code: A16AA07
Product: D05014<JP/US>
Efficacy
Metabolic homeostasis regulator, Leptin receptor agonist
  Disease
Lipodystrophy [DS:H01475]
Comment
Leptin [CPD:C18188] analog
Treatment of obesity and related disorders
Target
LEPR (CD295) [HSA:3953] [KO:K05062]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04080  Neuroactive ligand-receptor interaction
hsa04920  Adipocytokine signaling pathway
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
   A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
    A16AA Amino acids and derivatives
     A16AA07 Metreleptin
      D05014  Metreleptin (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Gastrointestinal Agents, Other
   Metreleptin
    D05014  Metreleptin (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2499  Others
     D05014  Metreleptin (USAN/INN); Mettreleptin (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   CSF and other factor receptors
    LEPR (CD295)
     D05014  Metreleptin (USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D05014
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D05014
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D05014
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D05014
Other DBs
CAS: 186018-45-1
PubChem: 47206741
LinkDB

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