Homo sapiens (human): 3953
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Entry
3953 CDS
T01001
Symbol
LEPR, CD295, LEP-R, LEPRD, OB-R, OBR
Name
(RefSeq) leptin receptor
KO
K05062
leptin receptor
Organism
hsa
Homo sapiens (human)
Pathway
hsa04060
Cytokine-cytokine receptor interaction
hsa04080
Neuroactive ligand-receptor interaction
hsa04152
AMPK signaling pathway
hsa04630
JAK-STAT signaling pathway
hsa04920
Adipocytokine signaling pathway
hsa04932
Non-alcoholic fatty liver disease
Network
nt06325
Hormone/cytokine signaling
nt06518
JAK-STAT signaling
Element
N01555
Hormone-like-cytokine to Jak-STAT signaling pathway
N01800
LEP-LEPR signaling pathway
Disease
H02060
Leptin receptor deficiency
Drug target
Metreleptin:
D05014
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
3953 (LEPR)
04152 AMPK signaling pathway
3953 (LEPR)
09133 Signaling molecules and interaction
04080 Neuroactive ligand-receptor interaction
3953 (LEPR)
04060 Cytokine-cytokine receptor interaction
3953 (LEPR)
09150 Organismal Systems
09152 Endocrine system
04920 Adipocytokine signaling pathway
3953 (LEPR)
09160 Human Diseases
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
3953 (LEPR)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04050 Cytokine receptors [BR:
hsa04050
]
3953 (LEPR)
04090 CD molecules [BR:
hsa04090
]
3953 (LEPR)
Cytokine receptors [BR:
hsa04050
]
Interleukin receptor families
Prolactin receptor family
3953 (LEPR)
CD molecules [BR:
hsa04090
]
Proteins
3953 (LEPR)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ObR_Ig
Lep_receptor_Ig
fn3
Motif
Other DBs
NCBI-GeneID:
3953
NCBI-ProteinID:
NP_002294
OMIM:
601007
HGNC:
6554
Ensembl:
ENSG00000116678
UniProt:
P48357
Structure
PDB
LinkDB
All DBs
Position
1:65420652..65641559
Genome browser
AA seq
1165 aa
AA seq
DB search
MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNS
NGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVF
QQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGS
FQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPP
LGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILP
GSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKI
VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHH
RYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIH
PISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP
SSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPV
PDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNV
TLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSI
GASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNED
GEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDA
GLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFI
KHTASVTCGPLLLEPETISEDISVDTSWKNKDEMMPTTVVSLLSTTDLEKGSVCISDQFN
SVNFSEAEGTEVTYEDESQRQPFVKYATLISNSKPSETGEEQGLINSSVTKCFSSKNSPL
KDSFSNSSWEIEAQAFFILSDQHPNIISPHLTFSEGLDELLKLEGNFPEENNDKKSIYYL
GVTSIKKRESGVLLTDKSRVSCPFPAPCLFTDIRVLQDSCSHFVENNINLGTSSKKTFAS
YMPQFQTCSTQTHKIMENKMCDLTV
NT seq
3498 nt
NT seq
+upstream
nt +downstream
nt
atgatttgtcaaaaattctgtgtggttttgttacattgggaatttatttatgtgataact
gcgtttaacttgtcatatccaattactccttggagatttaagttgtcttgcatgccacca
aattcaacctatgactacttccttttgcctgctggactctcaaagaatacttcaaattcg
aatggacattatgagacagctgttgaacctaagtttaattcaagtggtactcacttttct
aacttatccaaaacaactttccactgttgctttcggagtgagcaagatagaaactgctcc
ttatgtgcagacaacattgaaggaaagacatttgtttcaacagtaaattctttagttttt
caacaaatagatgcaaactggaacatacagtgctggctaaaaggagacttaaaattattc
atctgttatgtggagtcattatttaagaatctattcaggaattataactataaggtccat
cttttatatgttctgcctgaagtgttagaagattcacctctggttccccaaaaaggcagt
tttcagatggttcactgcaattgcagtgttcatgaatgttgtgaatgtcttgtgcctgtg
ccaacagccaaactcaacgacactctccttatgtgtttgaaaatcacatctggtggagta
attttccagtcacctctaatgtcagttcagcccataaatatggtgaagcctgatccacca
ttaggtttgcatatggaaatcacagatgatggtaatttaaagatttcttggtccagccca
ccattggtaccatttccacttcaatatcaagtgaaatattcagagaattctacaacagtt
atcagagaagctgacaagattgtctcagctacatccctgctagtagacagtatacttcct
gggtcttcgtatgaggttcaggtgaggggcaagagactggatggcccaggaatctggagt
gactggagtactcctcgtgtctttaccacacaagatgtcatatactttccacctaaaatt
ctgacaagtgttgggtctaatgtttcttttcactgcatctataagaaggaaaacaagatt
gttccctcaaaagagattgtttggtggatgaatttagctgagaaaattcctcaaagccag
tatgatgttgtgagtgatcatgttagcaaagttacttttttcaatctgaatgaaaccaaa
cctcgaggaaagtttacctatgatgcagtgtactgctgcaatgaacatgaatgccatcat
cgctatgctgaattatatgtgattgatgtcaatatcaatatctcatgtgaaactgatggg
tacttaactaaaatgacttgcagatggtcaaccagtacaatccagtcacttgcggaaagc
actttgcaattgaggtatcataggagcagcctttactgttctgatattccatctattcat
cccatatctgagcccaaagattgctatttgcagagtgatggtttttatgaatgcattttc
cagccaatcttcctattatctggctacacaatgtggattaggatcaatcactctctaggt
tcacttgactctccaccaacatgtgtccttcctgattctgtggtgaagccactgcctcca
tccagtgtgaaagcagaaattactataaacattggattattgaaaatatcttgggaaaag
ccagtctttccagagaataaccttcaattccagattcgctatggtttaagtggaaaagaa
gtacaatggaagatgtatgaggtttatgatgcaaaatcaaaatctgtcagtctcccagtt
ccagacttgtgtgcagtctatgctgttcaggtgcgctgtaagaggctagatggactggga
tattggagtaattggagcaatccagcctacacagttgtcatggatataaaagttcctatg
agaggacctgaattttggagaataattaatggagatactatgaaaaaggagaaaaatgtc
actttactttggaagcccctgatgaaaaatgactcattgtgcagtgttcagagatatgtg
ataaaccatcatacttcctgcaatggaacatggtcagaagatgtgggaaatcacacgaaa
ttcactttcctgtggacagagcaagcacatactgttacggttctggccatcaattcaatt
ggtgcttctgttgcaaattttaatttaaccttttcatggcctatgagcaaagtaaatatc
gtgcagtcactcagtgcttatcctttaaacagcagttgtgtgattgtttcctggatacta
tcacccagtgattacaagctaatgtattttattattgagtggaaaaatcttaatgaagat
ggtgaaataaaatggcttagaatctcttcatctgttaagaagtattatatccatgatcat
tttatccccattgagaagtaccagttcagtctttacccaatatttatggaaggagtggga
aaaccaaagataattaatagtttcactcaagatgatattgaaaaacaccagagtgatgca
ggtttatatgtaattgtgccagtaattatttcctcttccatcttattgcttggaacatta
ttaatatcacaccaaagaatgaaaaagctattttgggaagatgttccgaaccccaagaat
tgttcctgggcacaaggacttaattttcagaagccagaaacgtttgagcatctttttatc
aagcatacagcatcagtgacatgtggtcctcttcttttggagcctgaaacaatttcagaa
gatatcagtgttgatacatcatggaaaaataaagatgagatgatgccaacaactgtggtc
tctctactttcaacaacagatcttgaaaagggttctgtttgtattagtgaccagttcaac
agtgttaacttctctgaggctgagggtactgaggtaacctatgaggacgaaagccagaga
caaccctttgttaaatacgccacgctgatcagcaactctaaaccaagtgaaactggtgaa
gaacaagggcttataaatagttcagtcaccaagtgcttctctagcaaaaattctccgttg
aaggattctttctctaatagctcatgggagatagaggcccaggcattttttatattatca
gatcagcatcccaacataatttcaccacacctcacattctcagaaggattggatgaactt
ttgaaattggagggaaatttccctgaagaaaataatgataaaaagtctatctattattta
ggggtcacctcaatcaaaaagagagagagtggtgtgcttttgactgacaagtcaagggta
tcgtgcccattcccagccccctgtttattcacggacatcagagttctccaggacagttgc
tcacactttgtagaaaataatatcaacttaggaacttctagtaagaagacttttgcatct
tacatgcctcaattccaaacttgttctactcagactcataagatcatggaaaacaagatg
tgtgacctaactgtgtaa
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