Lipodystrophy;
Lipoatrophy

Lipodystrophies are a group of rare disorders characterized by selectively loss of fat tissue, which can be congential or acquired, and generalized or partial. People with the diseases more frequently appear severe metabolic abnormality including insulin resistance and its associated complications such as diabetes mellitus, hypertriglyceridemia, hepatic steatosis, polycystic ovaries, and acanthosis nigricans. Genetic predisposition to inherited lipodystrophies has been discovered. Compared with them, the causes of the acquired lipodystrophies are still unknown, but mainly related to autoimmune mechanism, medications or other unknown mechanisms.

Inherited metabolic disorder

Metreleptin [DR:D05014]
Tesamorelin acetate [DR:D09015]

Lipodystrophy can be classified to the following subtypes.
Genetic forms: Congential generalized lipodystrophy (CGL), H00420 Familial partial lipodystrophy (FPL), H00665 Mandibuloacral dysplasia-associated lipodystrophy (MDAL)
Acquired forms: H01474 Acquired generalized lipodystrophy (AGL), Acquired partial, HIV-associated lipodystrophy

PMID:21865368

PMID:25690482

PMID:26063386