KEGG   DRUG: Nonacog alfa
Entry
D05201                      Drug                                   
Name
Nonacog alfa (USAN/INN);
Nonacog alfa (genetical recombination) (JAN);
Benefix (TN)
Class
Blood modifier agent
 DG02016  Hemostatics
  DG02014  Blood coagulation accelerant
   DG02013  Blood coagulation factor
Remark
Therapeutic category: 6343
ATC code: B02BD04
Chemical structure group: DG00171
Product (DG00171): D08797<JP/US> D08794<JP> D05201<JP> D10757<JP> D10770<JP>
Efficacy
Bleeding suppressant, Replenisher (coagulation factor)
Comment
recombinant factor IX (F9) [HSA:2158] [KO:K01321]
Target
F9* [HSA_VAR:2158v1] [HSA:2158] [KO:K01321]
  Pathway
hsa04610  Complement and coagulation cascades
  Network
nt06514  Coagulation cascade
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02B VITAMIN K AND OTHER HEMOSTATICS
    B02BD Blood coagulation factors
     B02BD04 Coagulation factor IX
      D05201  Nonacog alfa (USAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  63  Biological preparations
   634  Human blood preparations
    6343  Plasma preparations
     D05201  Nonacog alfa (USAN/INN); Nonacog alfa (genetical recombination) (JAN)
Drug groups [BR:br08330]
 Blood modifier agent
  DG02016  Hemostatics
   DG02014  Blood coagulation accelerant
    DG02013  Blood coagulation factor
     DG00171  Blood coagulation factor IX
      D05201  Nonacog alfa
Target-based classification of drugs [BR:br08310]
 Peptidases and inhibitors
  Serine peptidases
   Chymotrypsin family
    F9* [HSA_VAR:2158v1]
     D05201  Nonacog alfa (USAN/INN) <JP>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D05201
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D05201
Drug groups [BR:br08330]
 Blood modifier agent
  DG02016  Hemostatics
   DG02014  Blood coagulation accelerant
    DG02013  Blood coagulation factor
     DG00171  Blood coagulation factor IX
Drug name stems [br08333.html]
 DG00171
Other DBs
CAS: 181054-95-5 113478-33-4
PubChem: 47206920
LinkDB

» Japanese version   » Back

KEGG   DRUG: Human blood-coagulation factor IX complex, dried
Entry
D08794                      Drug                                   
Name
Human blood-coagulation factor IX complex, dried;
PPSB-HT (TN)
Class
Blood modifier agent
 DG02016  Hemostatics
  DG02014  Blood coagulation accelerant
   DG02013  Blood coagulation factor
Remark
Therapeutic category: 6343
ATC code: B02BD04
Chemical structure group: DG00171
Product (DG00171): D08797<JP/US> D08794<JP> D05201<JP> D10757<JP> D10770<JP>
Efficacy
Bleeding suppressant, Replenisher (coagulation factor)
Target
F9* [HSA_VAR:2158v1] [HSA:2158] [KO:K01321]
  Pathway
hsa04610  Complement and coagulation cascades
  Network
nt06514  Coagulation cascade
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02B VITAMIN K AND OTHER HEMOSTATICS
    B02BD Blood coagulation factors
     B02BD04 Coagulation factor IX
      D08794  Human blood-coagulation factor IX complex, dried <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  63  Biological preparations
   634  Human blood preparations
    6343  Plasma preparations
     D08794  Human blood-coagulation factor IX complex, dried
Drug groups [BR:br08330]
 Blood modifier agent
  DG02016  Hemostatics
   DG02014  Blood coagulation accelerant
    DG02013  Blood coagulation factor
     DG00171  Blood coagulation factor IX
      D08794  Human blood-coagulation factor IX complex, dried
Target-based classification of drugs [BR:br08310]
 Peptidases and inhibitors
  Serine peptidases
   Chymotrypsin family
    F9* [HSA_VAR:2158v1]
     D08794  Human blood-coagulation factor IX complex, dried <JP>
Drug groups [BR:br08330]
 Blood modifier agent
  DG02016  Hemostatics
   DG02014  Blood coagulation accelerant
    DG02013  Blood coagulation factor
     DG00171  Blood coagulation factor IX
Drug name stems [br08333.html]
 DG00171
Other DBs
PubChem: 96025477
LinkDB

» Japanese version   » Back

KEGG   DRUG: Freeze-dried human blood-coagulation factor IX
Entry
D08797                      Drug                                   
Name
Freeze-dried human blood-coagulation factor IX;
Coagulation factor IX (recombinant);
Novact M (TN);
Rebinyn (TN);
Rixubis (TN)
Product
IXINITY (Medexus Pharma), REBINYN (Novo Nordisk)
Class
Blood modifier agent
 DG02016  Hemostatics
  DG02014  Blood coagulation accelerant
   DG02013  Blood coagulation factor
Remark
Therapeutic category: 6343
ATC code: B02BD04
Chemical structure group: DG00171
Product (DG00171): D08797<JP/US> D08794<JP> D05201<JP> D10757<JP> D10770<JP>
Efficacy
Bleeding suppressant, Replenisher (coagulation factor)
  Disease
Hemophilia B [DS:H00219]
Comment
See coagulation factor IXa [HSA:2158] [KO:K01321]
Target
F9* [HSA_VAR:2158v1] [HSA:2158] [KO:K01321]
  Pathway
hsa04610  Complement and coagulation cascades
  Network
nt06514  Coagulation cascade
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02B VITAMIN K AND OTHER HEMOSTATICS
    B02BD Blood coagulation factors
     B02BD04 Coagulation factor IX
      D08797  Freeze-dried human blood-coagulation factor IX <JP/US>
USP drug classification [BR:br08302]
 Blood Products and Modifiers
  Blood Component Deficiency/ Replacement
   Blood Component Deficiency/ Replacement, Hemophilia B
    Coagulation Factor IX (Recombinant)
     D08797  Freeze-dried human blood-coagulation factor IX
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  63  Biological preparations
   634  Human blood preparations
    6343  Plasma preparations
     D08797  Freeze-dried human blood-coagulation factor IX
Drug groups [BR:br08330]
 Blood modifier agent
  DG02016  Hemostatics
   DG02014  Blood coagulation accelerant
    DG02013  Blood coagulation factor
     DG00171  Blood coagulation factor IX
      D08797  Freeze-dried human blood-coagulation factor IX
Target-based classification of drugs [BR:br08310]
 Peptidases and inhibitors
  Serine peptidases
   Chymotrypsin family
    F9* [HSA_VAR:2158v1]
     D08797  Freeze-dried human blood-coagulation factor IX <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D08797
Drug groups [BR:br08330]
 Blood modifier agent
  DG02016  Hemostatics
   DG02014  Blood coagulation accelerant
    DG02013  Blood coagulation factor
     DG00171  Blood coagulation factor IX
Drug name stems [br08333.html]
 DG00171
Other DBs
PubChem: 96025480
LinkDB

» Japanese version   » Back

KEGG   DRUG: Eftrenonacog alfa
Entry
D10522                      Drug                                   
Name
Eftrenonacog alfa (INN);
Eftrenonacog alfa (genetical recombination) (JAN);
Alprolix (TN)
Formula
C4330H6648N1164O1331S41
Exact mass
97559.6852
Mol weight
97620.86
Sequence
(A chain)
YNSGKLEEFV QGNLERECME EKCSFEEARE VFENTERTTE FWKQYVDGDQ CESNPCLNGG
SCKDDINSYE CWCPFGFEGK NCELDVTCNI KNGRCEQFCK NSADNKVVCS CTEGYRLAEN
QKSCEPAVPF PCGRVSVSQT SKLTRAETVF PDVDYVNSTE AETILDNITQ STQSFNDFTR
VVGGEDAKPG QFPWQVVLNG KVDAFCGGSI VNEKWIVTAA HCVETGVKIT VVAGEHNIEE
TEHTEQKRNV IRIIPHHNYN AAINKYNHDI ALLELDEPLV LNSYVTPICI ADKEYTNIFL
KFGSGYVSGW GRVFHKGRSA LVLQYLRVPL VDRATCLRST KFTIYNNMFC AGFHEGGRDS
CQGDSGGPHV TEVEGTSFLT GIISWGEECA MKGKYGIYTK VSRYVNWIKE KTKLTDKTHT
CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH
NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE
PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF
LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GK
(B chain)
DKTHTCPPCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD
GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK
GQPREPQVYT LPPSRDELTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS
DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGK
(Disulfide bridge: A18-23, A51-62, A55-71, A73-82, A88-99, A95-109, A111-124, A132-289, A206-222, A336-350, A361-389, A421-B6, A424-B9, A456-516, B41-101, B147-205)
  Type
Peptide
Class
Blood modifier agent
 DG02016  Hemostatics
  DG02014  Blood coagulation accelerant
   DG02013  Blood coagulation factor
Remark
Therapeutic category: 6349
ATC code: B02BD04
Product: D10522<JP>
Efficacy
Bleeding suppressant, Replenisher (coagulation factor)
Target
F9* [HSA_VAR:2158v1] [HSA:2158] [KO:K01321]
  Pathway
hsa04610  Complement and coagulation cascades
  Network
nt06514  Coagulation cascade
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02B VITAMIN K AND OTHER HEMOSTATICS
    B02BD Blood coagulation factors
     B02BD04 Coagulation factor IX
      D10522  Eftrenonacog alfa (INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  63  Biological preparations
   634  Human blood preparations
    6349  Others
     D10522  Eftrenonacog alfa (INN); Eftrenonacog alfa (genetical recombination) (JAN)
Drug groups [BR:br08330]
 Blood modifier agent
  DG02016  Hemostatics
   DG02014  Blood coagulation accelerant
    DG02013  Blood coagulation factor
     D10522  Eftrenonacog alfa
Target-based classification of drugs [BR:br08310]
 Peptidases and inhibitors
  Serine peptidases
   Chymotrypsin family
    F9* [HSA_VAR:2158v1]
     D10522  Eftrenonacog alfa (INN) <JP>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10522
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10522
Other DBs
CAS: 1270012-74-2
PubChem: 254741484
LinkDB

» Japanese version   » Back

KEGG   DRUG: Nonacog beta pegol
Entry
D10757                      Drug                                   
Name
Nonacog beta pegol (INN);
Nonacog beta pegol (genetical recombination) (JAN);
Refixia (TN)
Formula
C2041H3114N558O641S25
Exact mass
46496.1245
Mol weight
46525.60
Sequence
YNSGKLXXFV QGNLXRXCMX XKCSFXXARX VFXNTXRTTX FWKQYVDGDQ CESNPCLNGG
SCKDDINSYE CWCPFGFEGK NCELDVTCNI KNGRCEQFCK NSADNKVVCS CTEGYRLAEN
QKSCEPAVPF PCGRVSVSQT SKLTRAEAVF PDVDYVNSTE AETILDNITQ STQSFNDFTR
VVGGEDAKPG QFPWQVVLNG KVDAFCGGSI VNEKWIVTAA HCVETGVKIT VVAGEHNIEE
TEHTEQKRNV IRIIPHHNYN AAINKYNHDI ALLELDEPLV LNSYVTPICI ADKEYTNIFL
KFGSGYVSGW GRVFHKGRSA LVLQYLRVPL VDRATCLRST KFTIYNNMFC AGFHEGGRDS
CQGDSGGPHV TEVEGTSFLT GIISWGEECA MKGKYGIYTK VSRYVNWIKE KTKLT
(Disulfide bridge: 18-23, 51-62, 56-71, 73-82, 88-99, 95-109, 111-124, 132-289, 206-222, 336-350, 361-389)
  Type
Peptide
Class
Blood modifier agent
 DG02016  Hemostatics
  DG02014  Blood coagulation accelerant
   DG02013  Blood coagulation factor
Remark
Therapeutic category: 6343
ATC code: B02BD04
Chemical structure group: DG00171
Product (DG00171): D08797<JP/US> D08794<JP> D05201<JP> D10757<JP> D10770<JP>
Efficacy
Bleeding suppressant, Replenisher (coagulation factor)
Comment
blood coagulation factor
Target
F9* [HSA_VAR:2158v1] [HSA:2158] [KO:K01321]
  Pathway
hsa04610  Complement and coagulation cascades
  Network
nt06514  Coagulation cascade
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02B VITAMIN K AND OTHER HEMOSTATICS
    B02BD Blood coagulation factors
     B02BD04 Coagulation factor IX
      D10757  Nonacog beta pegol (INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  63  Biological preparations
   634  Human blood preparations
    6343  Plasma preparations
     D10757  Nonacog beta pegol (INN); Nonacog beta pegol (genetical recombination) (JAN)
Drug groups [BR:br08330]
 Blood modifier agent
  DG02016  Hemostatics
   DG02014  Blood coagulation accelerant
    DG02013  Blood coagulation factor
     DG00171  Blood coagulation factor IX
      D10757  Nonacog beta pegol
Target-based classification of drugs [BR:br08310]
 Peptidases and inhibitors
  Serine peptidases
   Chymotrypsin family
    F9* [HSA_VAR:2158v1]
     D10757  Nonacog beta pegol (INN) <JP>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10757
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10757
Drug groups [BR:br08330]
 Blood modifier agent
  DG02016  Hemostatics
   DG02014  Blood coagulation accelerant
    DG02013  Blood coagulation factor
     DG00171  Blood coagulation factor IX
Drug name stems [br08333.html]
 DG00171
Other DBs
CAS: 1175512-71-6
PubChem: 295369347
LinkDB

» Japanese version   » Back

KEGG   DRUG: Albutrepenonacog alfa
Entry
D10770                      Drug                                   
Name
Albutrepenonacog alfa (INN);
Albutrepenonacog alfa (genetical recombination) (JAN);
Idelvion (TN)
Sequence
YNSGKLEEFV QGNLERECME EKCSFEEARE VFENTERTTE FWKQYVDGDQ CESNPCLNGG
SCKDDINSYE CWCPFGFEGK NCELDVTCNI KNGRCEQFCK NSADNKVVCS CTEGYRLAEN
QKSCEPAVPF PCGRVSVSQT SKLTRAETVF PDVDYVNSTE AETILDNITQ STQSFNDFTR
VVGGEDAKPG QFPWQVVLNG KVDAFCGGSI VNEKWIVTAA HCVETGVKIT VVAGEHNIEE
TEHTEQKRNV IRIIPHHNYN AAINKYNHDI ALLELDEPLV LNSYVTPICI ADKEYTNIFL
KFGSGYVSGW GRVFHKGRSA LVLQYLRVPL VDRATCLRST KFTIYNNMFC AGFHEGGRDS
CQGDSGGPHV TEVEGTSFLT GIISWGEECA MKGKYGIYTK VSRYVNWIKE KTKLTPVSQT
SKLTRAETVF PDVDAHKSEV AHRFKDLGEE NFKALVLIAF AQYLQQCPFE DHVKLVNEVT
EFAKTCVADE SAENCDKSLH TLFGDKLCTV ATLRETYGEM ADCCAKQEPE RNECFLQHKD
DNPNLPRLVR PEVDVMCTAF HDNEETFLKK YLYEIARRHP YFYAPELLFF AKRYKAAFTE
CCQAADKAAC LLPKLDELRD EGKASSAKQR LKCASLQKFG ERAFKAWAVA RLSQRFPKAE
FAEVSKLVTD LTKVHTECCH GDLLECADDR ADLAKYICEN QDSISSKLKE CCEKPLLEKS
HCIAEVENDE MPADLPSLAA DFVESKDVCK NYAEAKDVFL GMFLYEYARR HPDYSVVLLL
RLAKTYETTL EKCCAAADPH ECYAKVFDEF KPLVEEPQNL IKQNCELFEQ LGEYKFQNAL
LVRYTKKVPQ VSTPTLVEVS RNLGKVGSKC CKHPEAKRMP CAEDYLSVVL NQLCVLHEKT
PVSDRVTKCC TESLVNRRPC FSALEVDETY VPKEFNAETF TFHADICTLS EKERQIKKQT
ALVELVKHKP KATKEQLKAV MDDFAAFVEK CCKADDKETC FAEEGKKLVA ASQAALGL
(Disulfide bridge: 18-23, 51-62, 56-71, 73-82, 88-99, 95-109, 111-124, 132-289, 206-222, 336-350, 361-389, 486-495, 508-524, 523-534, 557-602, 601-610, 633-679, 698-712, 711-722, 749-794, 793-802, 825-871, 870-881, 894-910, 909-920, 947-992, 991-1000)
  Type
Peptide
Class
Blood modifier agent
 DG02016  Hemostatics
  DG02014  Blood coagulation accelerant
   DG02013  Blood coagulation factor
Remark
Therapeutic category: 6349
ATC code: B02BD04
Chemical structure group: DG00171
Product (DG00171): D08797<JP/US> D08794<JP> D05201<JP> D10757<JP> D10770<JP>
Efficacy
Bleeding suppressant, Replenisher (coagulation factor)
Target
F9* [HSA_VAR:2158v1] [HSA:2158] [KO:K01321]
  Pathway
hsa04610  Complement and coagulation cascades
  Network
nt06514  Coagulation cascade
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02B VITAMIN K AND OTHER HEMOSTATICS
    B02BD Blood coagulation factors
     B02BD04 Coagulation factor IX
      D10770  Albutrepenonacog alfa (INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  63  Biological preparations
   634  Human blood preparations
    6349  Others
     D10770  Albutrepenonacog alfa (INN); Albutrepenonacog alfa (genetical recombination) (JAN)
Drug groups [BR:br08330]
 Blood modifier agent
  DG02016  Hemostatics
   DG02014  Blood coagulation accelerant
    DG02013  Blood coagulation factor
     DG00171  Blood coagulation factor IX
      D10770  Albutrepenonacog alfa
Target-based classification of drugs [BR:br08310]
 Peptidases and inhibitors
  Serine peptidases
   Chymotrypsin family
    F9* [HSA_VAR:2158v1]
     D10770  Albutrepenonacog alfa (INN) <JP>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10770
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10770
Drug groups [BR:br08330]
 Blood modifier agent
  DG02016  Hemostatics
   DG02014  Blood coagulation accelerant
    DG02013  Blood coagulation factor
     DG00171  Blood coagulation factor IX
Drug name stems [br08333.html]
 DG00171
Other DBs
CAS: 1357448-54-4
PubChem: 310920488
LinkDB

» Japanese version   » Back

KEGG   DRUG: Fidanacogene elaparvovec
Entry
D12908                      Drug                                   
Name
Fidanacogene elaparvovec (USAN/INN);
Fidanacogene elaparvovec-dzkt;
Beqvez (TN)
Class
Blood modifier agent
 DG02016  Hemostatics
  DG02014  Blood coagulation accelerant
   DG02013  Blood coagulation factor
Remark
ATC code: B02BD17
Efficacy
Bleeding suppressant
  Disease
Hemophilia B, congenital factor IX deficiency [DS:H00219]
  Type
Gene therapy product
Comment
Recombinant adeno-associated virus vector, Spark100, containing the human blood- coagulation factor IX padua variant gene
Treatment of hemophilia B
Target
F9* [HSA_VAR:2158v1] [HSA:2158] [KO:K01321]
  Pathway
hsa04610  Complement and coagulation cascades
  Network
nt06514  Coagulation cascade
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02B VITAMIN K AND OTHER HEMOSTATICS
    B02BD Blood coagulation factors
     B02BD17 Fidanacogene elaparvovec
      D12908  Fidanacogene elaparvovec (USAN/INN)
Drug groups [BR:br08330]
 Blood modifier agent
  DG02016  Hemostatics
   DG02014  Blood coagulation accelerant
    DG02013  Blood coagulation factor
     D12908  Fidanacogene elaparvovec
Target-based classification of drugs [BR:br08310]
 Peptidases and inhibitors
  Serine peptidases
   Chymotrypsin family
    F9* [HSA_VAR:2158v1]
     D12908  Fidanacogene elaparvovec (USAN/INN)
New drug approvals in the USA [br08319.html]
 Cellular and gene therapy products
  D12908
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D12908
 Cellular and gene therapy products
  D12908
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D12908
Other DBs
CAS: 1954659-47-2
PubChem: 497621321
LinkDB

» Japanese version   » Back

DBGET integrated database retrieval system