| Entry |
|
|---|
| Name |
Olmesartan (USAN/INN) |
|---|
| Formula |
C24H26N6O3
|
|---|
| Exact mass |
446.2066
|
|---|
| Mol weight |
446.5016
|
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| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01495 Angiotensin II receptor antagonist
DG03231 Antihypertensive
DG01495 Angiotensin II receptor antagonist
Transporter substrate
DG01665 ABCB1 substrate
DG02861 ABCC2 substrate
DG01913 ABCG2 substrate
|
|---|
| Remark |
| Product (DG01544): | D01204<JP/US> |
|
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| Efficacy |
Antihypertensive, Angiotensin II receptor antagonist |
|---|
| Comment |
Treatment of hypertension
|
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| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Metabolism |
Transporter: ABCC2 [HSA: 1244], ABCB1 [HSA: 5243], ABCG2 [HSA: 9429]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07229 | Angiotensin receptor and endothelin receptor antagonists |
|
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| Other map |
|
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| Brite |
Drug groups [BR:br08330]
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01495 Angiotensin II receptor antagonist
DG01544 Olmesartan
D05246 Olmesartan
DG03231 Antihypertensive
DG01495 Angiotensin II receptor antagonist
DG01544 Olmesartan
D05246 Olmesartan
Transporter substrate
DG01665 ABCB1 substrate
DG01544 Olmesartan
D05246 Olmesartan
DG02861 ABCC2 substrate
DG01544 Olmesartan
D05246 Olmesartan
DG01913 ABCG2 substrate
DG01544 Olmesartan
D05246 Olmesartan
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Angiotensin
AGTR1
D05246 Olmesartan (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug transporters
D05246
Prodrugs [br08324.html]
D05246
Drug groups [BR:br08330]
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01495 Angiotensin II receptor antagonist
DG01544 Olmesartan
DG03231 Antihypertensive
DG01495 Angiotensin II receptor antagonist
DG01544 Olmesartan
Transporter substrate
DG01665 ABCB1 substrate
DG01544 Olmesartan
DG02861 ABCC2 substrate
DG01544 Olmesartan
DG01913 ABCG2 substrate
DG01544 Olmesartan
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 33
1 C1d C 30.1124 -16.1644
2 C8y C 29.4120 -14.9513
3 O1a O 29.4120 -17.3776
4 C6a C 27.3107 -16.1644
5 O6a O 28.0112 -17.3776
6 C8y C 28.0112 -14.9513
7 C1b C 26.3656 -12.9132
8 C8y C 25.1490 -13.6075
9 N4y N 27.5753 -13.6198
10 N5x N 29.8481 -13.6198
11 C8y C 28.7116 -12.7933
12 C8x C 23.9417 -12.8984
13 C8x C 22.7250 -13.5926
14 C8y C 22.7178 -14.9934
15 C8x C 23.9275 -15.7000
16 C8x C 25.1443 -15.0058
17 C8y C 21.5012 -15.6877
18 C8y C 20.2956 -14.9759
19 C8x C 19.0790 -15.6703
20 C8x C 19.1419 -17.0711
21 C8x C 20.2815 -17.7776
22 C8x C 21.4982 -17.0833
23 C8y C 20.3062 -13.5751
24 N5x N 21.4481 -12.7573
25 N5x N 21.0251 -11.4219
26 N5x N 19.6244 -11.4117
27 N4x N 19.1816 -12.7405
28 C1a C 31.0959 -15.1634
29 C1a C 31.0959 -17.1516
30 O6a O 25.9099 -16.1644
31 C1b C 28.7116 -11.3925
32 C1b C 27.4984 -10.6921
33 C1a C 26.2851 -11.3925
BOND 36
1 12 13 1
2 13 14 2
3 14 15 1
4 15 16 2
5 16 8 1
6 4 6 1
7 14 17 1
8 7 8 1
9 7 9 1
10 17 18 2
11 18 19 1
12 19 20 2
13 20 21 1
14 21 22 2
15 22 17 1
16 1 2 1
17 18 23 1
18 2 10 1
19 10 11 2
20 11 9 1
21 23 24 2
22 24 25 1
23 25 26 2
24 26 27 1
25 27 23 1
26 9 6 1
27 6 2 2
28 1 28 1
29 1 3 1
30 1 29 1
31 4 30 2
32 4 5 1
33 11 31 1
34 31 32 1
35 8 12 2
36 32 33 1
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