KEGG   DRUG: Olmesartan medoxomil
Entry
D01204                      Drug                                   
Name
Olmesartan medoxomil (JP18/USP);
Benicar (TN);
Olmetec (TN)
Product
BENICAR (Cosette Pharmaceuticals)
  Generic
OLMESARTAN MEDOXOMIL (A-S Medication Solutions), OLMESARTAN MEDOXOMIL (A-S Medication Solutions), OLMESARTAN MEDOXOMIL (A-S Medication Solutions), OLMESARTAN MEDOXOMIL (A-S Medication Solutions), OLMESARTAN MEDOXOMIL (A-S Medication Solutions), OLMESARTAN MEDOXOMIL (A-S Medication Solutions), OLMESARTAN MEDOXOMIL (A-S Medication Solutions), OLMESARTAN MEDOXOMIL (A-S Medication Solutions), OLMESARTAN MEDOXOMIL (Accord Healthcare), OLMESARTAN MEDOXOMIL (Alembic Pharmaceuticals Limited), OLMESARTAN MEDOXOMIL (Alembic Pharmaceuticals), OLMESARTAN MEDOXOMIL (Amneal Pharmaceuticals LLC), OLMESARTAN MEDOXOMIL (Ascend Laboratories), OLMESARTAN MEDOXOMIL (Aurobindo Pharma Limited), OLMESARTAN MEDOXOMIL (Bryant Ranch Prepack), OLMESARTAN MEDOXOMIL (Bryant Ranch Prepack), OLMESARTAN MEDOXOMIL (Bryant Ranch Prepack), OLMESARTAN MEDOXOMIL (Bryant Ranch Prepack), OLMESARTAN MEDOXOMIL (Bryant Ranch Prepack), OLMESARTAN MEDOXOMIL (Bryant Ranch Prepack), OLMESARTAN MEDOXOMIL (Bryant Ranch Prepack), OLMESARTAN MEDOXOMIL (Bryant Ranch Prepack), OLMESARTAN MEDOXOMIL (Direct_Rx), OLMESARTAN MEDOXOMIL (Glenmark Pharmaceuticals), OLMESARTAN MEDOXOMIL (Golden State Medical Supply), OLMESARTAN MEDOXOMIL (Inventia Healthcare Limited), OLMESARTAN MEDOXOMIL (Lannett Company), OLMESARTAN MEDOXOMIL (Lifestar Pharma LLC), OLMESARTAN MEDOXOMIL (Macleods Pharmaceuticals Limited), OLMESARTAN MEDOXOMIL (Micro Labs Limited), OLMESARTAN MEDOXOMIL (Novadoz Pharmaceuticals LLC), OLMESARTAN MEDOXOMIL (Proficient Rx LP), OLMESARTAN MEDOXOMIL (Proficient Rx LP), OLMESARTAN MEDOXOMIL (QUALLENT PHARMACEUTICALS HEALTH LLC), OLMESARTAN MEDOXOMIL (REMEDYREPACK), OLMESARTAN MEDOXOMIL (REMEDYREPACK), OLMESARTAN MEDOXOMIL (REMEDYREPACK), OLMESARTAN MEDOXOMIL (Rising Pharma Holdings), OLMESARTAN MEDOXOMIL (ScieGen Pharmaceuticals), OLMESARTAN MEDOXOMIL (Solco Healthcare US), OLMESARTAN MEDOXOMIL (Tris Pharma), OLMESARTAN MEDOXOMIL (Zydus Lifesciences Limited), OLMESARTAN MEDOXOMIL (Zydus Pharmaceuticals USA), OLMESARTAN MEDOXOMIL (direct rx)
Formula
C29H30N6O6
Exact mass
558.2227
Mol weight
558.5851
Structure
Class
Cardiovascular agent
 DG01925  Renin-angiotensin system inhibitor
  DG01495  Angiotensin II receptor antagonist
 DG03231  Antihypertensive
  DG01495  Angiotensin II receptor antagonist
Transporter substrate
 DG01665  ABCB1 substrate
 DG02861  ABCC2 substrate
 DG01913  ABCG2 substrate
Remark
Therapeutic category: 2149
ATC code: C09CA08
Chemical structure group: DG01544
Product (DG01544): D01204<JP/US>
Product (mixture): D09594<JP> D10284<US> D10285<US> D10288<US>
Efficacy
Antihypertensive, Angiotensin II receptor antagonist
  Disease
Hypertension [DS:H01633]
Comment
Active form of prodrug: Olmesartan [DR:D05246]
Target
AGTR1 [HSA:185] [KO:K04166]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04614  Renin-angiotensin system
Metabolism
Transporter: ABCC2 [HSA:1244], ABCB1 [HSA:5243], ABCG2 [HSA:9429]
Interaction
Structure map
map07229  Angiotensin receptor and endothelin receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09C ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), PLAIN
    C09CA Angiotensin II receptor blockers (ARBs), plain
     C09CA08 Olmesartan medoxomil
      D01204  Olmesartan medoxomil (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin II Receptor Antagonists
   Olmesartan
    D01204  Olmesartan medoxomil (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D01204  Olmesartan medoxomil (JP18/USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01495  Angiotensin II receptor antagonist
    DG01544  Olmesartan
     D01204  Olmesartan medoxomil
  DG03231  Antihypertensive
   DG01495  Angiotensin II receptor antagonist
    DG01544  Olmesartan
     D01204  Olmesartan medoxomil
 Transporter substrate
  DG01665  ABCB1 substrate
   DG01544  Olmesartan
    D01204  Olmesartan medoxomil
  DG02861  ABCC2 substrate
   DG01544  Olmesartan
    D01204  Olmesartan medoxomil
  DG01913  ABCG2 substrate
   DG01544  Olmesartan
    D01204  Olmesartan medoxomil
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01495  Angiotensin II receptor antagonist
   D01204  Olmesartan medoxomil
  DG03231  Antihypertensive
   D01204  Olmesartan medoxomil
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Angiotensin
    AGTR1
     D01204  Olmesartan medoxomil (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01204  Olmesartan medoxomil
  D01204  Olmesartan medoxomil tablets
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01204
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01204
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01204
Drug metabolizing enzymes and transporters [br08309.html]
 Drug transporters
  D01204
Prodrugs [br08324.html]
 D01204
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01495  Angiotensin II receptor antagonist
    DG01544  Olmesartan
  DG03231  Antihypertensive
   DG01495  Angiotensin II receptor antagonist
    DG01544  Olmesartan
 Transporter substrate
  DG01665  ABCB1 substrate
   DG01544  Olmesartan
  DG02861  ABCC2 substrate
   DG01544  Olmesartan
  DG01913  ABCG2 substrate
   DG01544  Olmesartan
Other DBs
CAS: 144689-63-4
PubChem: 7848267
ChEBI: 31932
LigandBox: D01204
NIKKAJI: J689.130F
LinkDB
KCF data

ATOM        41
            1   C1a C    37.1157  -18.9063
            2   C8y C    36.4167  -20.1172
            3   C8y C    35.0273  -20.1154
            4   O7x O    34.6625  -21.4576
            5   C8y C    35.8267  -22.2192
            6   O7x O    36.9105  -21.3475
            7   C1d C    37.1245  -16.2033
            8   C8y C    36.4254  -14.9925
            9   C7a C    34.3282  -16.2033
            10  O7a O    35.0273  -17.4142
            11  C8y C    35.0273  -14.9925
            12  C1b C    33.3849  -12.9584
            13  C8y C    32.1706  -13.6513
            14  N4y N    34.5923  -13.6636
            15  N5x N    36.8607  -13.6636
            16  C8y C    35.7264  -12.8387
            17  C8x C    30.9657  -12.9436
            18  C8x C    29.7513  -13.6365
            19  C8y C    29.7441  -15.0346
            20  C8x C    30.9515  -15.7398
            21  C8x C    32.1659  -15.0469
            22  C8y C    28.5299  -15.7275
            23  C8y C    27.3266  -15.0171
            24  C8x C    26.1123  -15.7102
            25  C8x C    26.1051  -17.1083
            26  C8x C    27.3125  -17.8134
            27  C8x C    28.5269  -17.1204
            28  C8y C    27.2672  -13.6190
            29  N5x N    28.4069  -12.8028
            30  N5x N    27.9847  -11.4699
            31  N5x N    26.5867  -11.4598
            32  N4x N    26.1447  -12.7860
            33  C1b C    34.3282  -18.6250
            34  O6a O    35.8253  -23.6158
            35  O6a O    32.9301  -16.2033
            36  C1b C    35.7264  -11.4406
            37  C1b C    34.5155  -10.7415
            38  C1a C    33.3046  -11.4406
            39  C1a C    37.8245  -17.4158
            40  C1a C    38.3324  -15.5058
            41  O1a O    35.9087  -16.6254
BOND        45
            1    17  18 1
            2    18  19 2
            3    19  20 1
            4    20  21 2
            5    21  13 1
            6     9  11 1
            7    19  22 1
            8     2   3 2
            9    12  13 1
            10    1   2 1
            11   12  14 1
            12   22  23 2
            13   23  24 1
            14   24  25 2
            15   25  26 1
            16   26  27 2
            17   27  22 1
            18    7   8 1
            19   23  28 1
            20    3   4 1
            21    8  15 1
            22   15  16 2
            23   16  14 1
            24   28  29 2
            25   29  30 1
            26   30  31 2
            27   31  32 1
            28   32  28 1
            29   14  11 1
            30   10  33 1
            31   33   3 1
            32   11   8 2
            33    4   5 1
            34    5  34 2
            35    5   6 1
            36    9  35 2
            37    9  10 1
            38   16  36 1
            39    6   2 1
            40   36  37 1
            41   13  17 2
            42   37  38 1
            43    7  39 1
            44    7  40 1
            45    7  41 1

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