KEGG   DRUG: Olmesartan medoxomilHelp
Entry
D01204                      Drug                                   

Name
Olmesartan medoxomil (JP17/USAN);
Olmesartan medoxomil tablets (JP17);
Benicar (TN);
Olmetec (TN)
Product
  Generic
OLMESARTAN MEDOXOMIL (A-S Medication Solutions), OLMESARTAN MEDOXOMIL (A-S Medication Solutions), OLMESARTAN MEDOXOMIL (A-S Medication Solutions), OLMESARTAN MEDOXOMIL (A-S Medication Solutions), OLMESARTAN MEDOXOMIL (A-S Medication Solutions), OLMESARTAN MEDOXOMIL (Accord Healthcare), OLMESARTAN MEDOXOMIL (Alembic Pharmaceuticals), OLMESARTAN MEDOXOMIL (Alembic Pharmaceuticals Limited), OLMESARTAN MEDOXOMIL (Apotex Corp.), OLMESARTAN MEDOXOMIL (Ascend Laboratories), OLMESARTAN MEDOXOMIL (Aurobindo Pharma Limited), OLMESARTAN MEDOXOMIL (AvKARE), OLMESARTAN MEDOXOMIL (Bryant Ranch Prepack), OLMESARTAN MEDOXOMIL (Bryant Ranch Prepack), OLMESARTAN MEDOXOMIL (Bryant Ranch Prepack), OLMESARTAN MEDOXOMIL (Cadila Healthcare Limited), OLMESARTAN MEDOXOMIL (Glenmark Pharmaceuticals), OLMESARTAN MEDOXOMIL (Jubilant Cadista Pharmaceuticals), OLMESARTAN MEDOXOMIL (Lupin Pharmaceuticals), OLMESARTAN MEDOXOMIL (Macleods Pharmaceuticals Limited), OLMESARTAN MEDOXOMIL (Mylan Institutional), OLMESARTAN MEDOXOMIL (Mylan Pharmaceuticals), OLMESARTAN MEDOXOMIL (REMEDYREPACK), OLMESARTAN MEDOXOMIL (REMEDYREPACK), OLMESARTAN MEDOXOMIL (ScieGen Pharmaceuticals), OLMESARTAN MEDOXOMIL (Teva Pharmaceuticals USA), OLMESARTAN MEDOXOMIL (Torrent Pharmaceuticals Limited), OLMESARTAN MEDOXOMIL (Zydus Pharmaceuticals (USA))
Formula
C29H30N6O6
Exact mass
558.2227
Mol weight
558.5851
Structure
Mol fileKCF fileDB search
Class
Cardiovascular agent
 DG01495  Angiotensin II receptor antagonist
 DG01925  Renin-angiotensin system inhibitor
  DG01495  Angiotensin II receptor antagonist
Transporter substrate
 DG01665  ABCB1(P-GP) substrate
 DG02861  ABCC2 (MRP2) substrate
 DG01913  ABCG2 substrate
Remark
Therapeutic category: 2149
ATC code: C09CA08
Chemical structure group: DG01544
Product (DG01544): D01204<JP/US>
Product (mixture): D09594<JP> D10284<US> D10285<US> D10288<US>
Efficacy
Antihypertensive, Angiotensin II receptor antagonist
  Disease
Hypertension [DS:H01633]
Comment
Active form of prodrug: Olmesartan [DR:D05246]
Target
AGTR1 [HSA:185] [KO:K04166]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04614  Renin-angiotensin system
Metabolism
Transporter: ABCC2 [HSA:1244], ABCB1 [HSA:5243], ABCG2 [HSA:9429]
Interaction
Drug interaction
Structure map
map07229  Angiotensin receptor and endothelin receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09C ANGIOTENSIN II ANTAGONISTS, PLAIN
    C09CA Angiotensin II antagonists, plain
     C09CA08 Olmesartan medoxomil
      D01204  Olmesartan medoxomil (JP17/USAN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin II Receptor Antagonists
   Olmesartan
    D01204  Olmesartan medoxomil (JP17/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D01204  Olmesartan medoxomil (JP17/USAN); Olmesartan medoxomil tablets (JP17)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Angiotensin
    AGTR1
     D01204  Olmesartan medoxomil (JP17/USAN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01204  Olmesartan medoxomil
  D01204  Olmesartan medoxomil tablets
Drug classes of therapeutic agents [br08360.html]
 Cardiovascular agents
  D01204
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D01204
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01204
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01204
Prodrugs [br08324.html]
 D01204
BRITE hierarchy
Other DBs
CAS: 144689-63-4
PubChem: 7848267
ChEBI: 31932
ChEMBL: CHEMBL1200692
DrugBank: DB00275
LigandBox: D01204
NIKKAJI: J689.130F
LinkDB All DBs
KCF data Show

ATOM        41
            1   C1a C    37.1157  -18.9063
            2   C8y C    36.4167  -20.1172
            3   C8y C    35.0273  -20.1154
            4   O7x O    34.6625  -21.4576
            5   C8y C    35.8267  -22.2192
            6   O7x O    36.9105  -21.3475
            7   C1d C    37.1245  -16.2033
            8   C8y C    36.4254  -14.9925
            9   C7a C    34.3282  -16.2033
            10  O7a O    35.0273  -17.4142
            11  C8y C    35.0273  -14.9925
            12  C1b C    33.3849  -12.9584
            13  C8y C    32.1706  -13.6513
            14  N4y N    34.5923  -13.6636
            15  N5x N    36.8607  -13.6636
            16  C8y C    35.7264  -12.8387
            17  C8x C    30.9657  -12.9436
            18  C8x C    29.7513  -13.6365
            19  C8y C    29.7441  -15.0346
            20  C8x C    30.9515  -15.7398
            21  C8x C    32.1659  -15.0469
            22  C8y C    28.5299  -15.7275
            23  C8y C    27.3266  -15.0171
            24  C8x C    26.1123  -15.7102
            25  C8x C    26.1051  -17.1083
            26  C8x C    27.3125  -17.8134
            27  C8x C    28.5269  -17.1204
            28  C8y C    27.2672  -13.6190
            29  N5x N    28.4069  -12.8028
            30  N5x N    27.9847  -11.4699
            31  N5x N    26.5867  -11.4598
            32  N4x N    26.1447  -12.7860
            33  C1b C    34.3282  -18.6250
            34  O6a O    35.8253  -23.6158
            35  O6a O    32.9301  -16.2033
            36  C1b C    35.7264  -11.4406
            37  C1b C    34.5155  -10.7415
            38  C1a C    33.3046  -11.4406
            39  C1a C    37.8245  -17.4158
            40  C1a C    38.3324  -15.5058
            41  O1a O    35.9087  -16.6254
BOND        45
            1    17  18 1
            2    18  19 2
            3    19  20 1
            4    20  21 2
            5    21  13 1
            6     9  11 1
            7    19  22 1
            8     2   3 2
            9    12  13 1
            10    1   2 1
            11   12  14 1
            12   22  23 2
            13   23  24 1
            14   24  25 2
            15   25  26 1
            16   26  27 2
            17   27  22 1
            18    7   8 1
            19   23  28 1
            20    3   4 1
            21    8  15 1
            22   15  16 2
            23   16  14 1
            24   28  29 2
            25   29  30 1
            26   30  31 2
            27   31  32 1
            28   32  28 1
            29   14  11 1
            30   10  33 1
            31   33   3 1
            32   11   8 2
            33    4   5 1
            34    5  34 2
            35    5   6 1
            36    9  35 2
            37    9  10 1
            38   16  36 1
            39    6   2 1
            40   36  37 1
            41   13  17 2
            42   37  38 1
            43    7  39 1
            44    7  40 1
            45    7  41 1

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