KEGG   DRUG: Pegsunercept
Entry
D05393                      Drug                                   
Name
Pegsunercept (USAN)
Formula
C502H758N154O165S16
Exact mass
12095.1188
Mol weight
12103.40
Sequence
MDSVCPQGKY IHPQNNSICC TKCHKGTYLY NDCPGPGQDT DCRECESGSF TASENHLRHC
LSCSKCRKEM GQVEISSCTV DRDTVCGCRK NQYRHYWSEN LFQCFN
(Disulfide bridge: 5-19, 20-33, 23-42, 63-78, 66-86, 88-104)
  Type
Peptide
Class
Anti-inflammatory
 DG01985  Disease modifying anti-rheumatic drug (DMARD)
  DG01936  TNF inhibitor
Efficacy
Anti-inflammatory, TNF-alpha inhibitor
Comment
a PEGylated protein (a polyethylene-glycol-modified soluble tumor-necrosis-factor receptor type 1)
Treatment of inflammatory and autoimmune conditions (e.g. rheumatoid arthritis, Crohn's disease) (binds and therapy inhibits the inflammatory activity of tumor necrosis factor)
Target
TNF (TNFA, TNFSF2) [HSA:7124] [KO:K03156]
  Pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04064  NF-kappa B signaling pathway
hsa04150  mTOR signaling pathway
hsa04350  TGF-beta signaling pathway
Interaction
Brite
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01985  Disease modifying anti-rheumatic drug (DMARD)
   DG01936  TNF inhibitor
    D05393  Pegsunercept
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Tumor necrosis factors
    TNF (TNFA, TNFSF2)
     D05393  Pegsunercept (USAN)
Other DBs
CAS: 330988-75-5
PubChem: 47207069
LinkDB

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