Homo sapiens (human): 7124
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Entry
7124 CDS
T01001
Symbol
TNF, DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F
Name
(RefSeq) tumor necrosis factor
KO
K03156
tumor necrosis factor superfamily, member 2
Organism
hsa
Homo sapiens (human)
Pathway
hsa01523
Antifolate resistance
hsa04010
MAPK signaling pathway
hsa04060
Cytokine-cytokine receptor interaction
hsa04061
Viral protein interaction with cytokine and cytokine receptor
hsa04064
NF-kappa B signaling pathway
hsa04071
Sphingolipid signaling pathway
hsa04150
mTOR signaling pathway
hsa04210
Apoptosis
hsa04217
Necroptosis
hsa04350
TGF-beta signaling pathway
hsa04380
Osteoclast differentiation
hsa04612
Antigen processing and presentation
hsa04620
Toll-like receptor signaling pathway
hsa04621
NOD-like receptor signaling pathway
hsa04622
RIG-I-like receptor signaling pathway
hsa04625
C-type lectin receptor signaling pathway
hsa04640
Hematopoietic cell lineage
hsa04650
Natural killer cell mediated cytotoxicity
hsa04657
IL-17 signaling pathway
hsa04660
T cell receptor signaling pathway
hsa04664
Fc epsilon RI signaling pathway
hsa04668
TNF signaling pathway
hsa04920
Adipocytokine signaling pathway
hsa04930
Type II diabetes mellitus
hsa04931
Insulin resistance
hsa04932
Non-alcoholic fatty liver disease
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa04936
Alcoholic liver disease
hsa04940
Type I diabetes mellitus
hsa05010
Alzheimer disease
hsa05014
Amyotrophic lateral sclerosis
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05130
Pathogenic Escherichia coli infection
hsa05131
Shigellosis
hsa05132
Salmonella infection
hsa05133
Pertussis
hsa05134
Legionellosis
hsa05135
Yersinia infection
hsa05140
Leishmaniasis
hsa05142
Chagas disease
hsa05143
African trypanosomiasis
hsa05144
Malaria
hsa05145
Toxoplasmosis
hsa05146
Amoebiasis
hsa05152
Tuberculosis
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05163
Human cytomegalovirus infection
hsa05164
Influenza A
hsa05165
Human papillomavirus infection
hsa05166
Human T-cell leukemia virus 1 infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05171
Coronavirus disease - COVID-19
hsa05205
Proteoglycans in cancer
hsa05310
Asthma
hsa05321
Inflammatory bowel disease
hsa05322
Systemic lupus erythematosus
hsa05323
Rheumatoid arthritis
hsa05330
Allograft rejection
hsa05332
Graft-versus-host disease
hsa05410
Hypertrophic cardiomyopathy
hsa05414
Dilated cardiomyopathy
hsa05417
Lipid and atherosclerosis
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06166
Human papillomavirus (HPV)
nt06167
Human cytomegalovirus (HCMV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06169
Measles virus (MV)
nt06171
SARS coronavirus 2 (SARS-CoV-2)
nt06180
Pathogenic Escherichia coli
nt06181
Salmonella
nt06182
Shigella
nt06183
Yersinia
nt06223
TNF signaling (cancer)
nt06231
Apoptosis (cancer)
nt06263
Hepatocellular carcinoma
nt06460
Alzheimer disease
nt06461
Huntington disease
nt06466
Pathways of neurodegeneration
nt06516
TNF signaling
nt06517
TLR signaling
nt06524
Apoptosis
nt06527
Necroptosis
Element
N00145
Extrinsic apoptotic pathway
N00151
TNF-NFKB signaling pathway
N00374
TNF-IRF1 signaling pathway
N00435
TLR1/2/4-NFKB signaling pathway
N00436
HIV Tat to TLR2/4-NFKB signaling pathway
N00444
TNF-p38 signaling pathway
N00446
TNF-JNK signaling pathway
N00994
AGE-RAGE signaling pathway
N00996
Mutation-caused aberrant Abeta to AGE-RAGE signaling pathway
N01307
SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
N01566
TLR5-NFKB signaling pathway
N01621
TNF-RIPK1/3 signaling pathway
Disease
H00079
Asthma
H00080
Systemic lupus erythematosus
H00083
Allograft rejection
H00084
Graft-versus-host disease
H00361
Malaria
H02525
Disorders of innate immunity
Drug target
Adalimumab:
D02597
<JP/US>
Adalimumab fosimdesonide:
D12790
Afelimomab:
D07436
Certolizumab pegol:
D03441
<JP/US>
Etanercept:
D00742
<JP/US>
Golimumab:
D04358
<JP/US>
Infliximab:
D02598
<JP/US>
Lenalidomide (
DG00744
):
D04687
<JP/US>
D09813
<JP>
Lenercept:
D04690
Licaminlimab:
D12420
Nerelimomab:
D05146
Onercept:
D05263
Opinercept:
D11703
Ozoralizumab:
D09944
<JP>
Pegsunercept:
D05393
Pirfenidone:
D01583
<JP/US>
Placulumab:
D10320
Pomalidomide:
D08976
<JP/US>
Thalidomide:
D00754
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
7124 (TNF)
04350 TGF-beta signaling pathway
7124 (TNF)
04064 NF-kappa B signaling pathway
7124 (TNF)
04668 TNF signaling pathway
7124 (TNF)
04071 Sphingolipid signaling pathway
7124 (TNF)
04150 mTOR signaling pathway
7124 (TNF)
09133 Signaling molecules and interaction
04060 Cytokine-cytokine receptor interaction
7124 (TNF)
04061 Viral protein interaction with cytokine and cytokine receptor
7124 (TNF)
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
7124 (TNF)
04217 Necroptosis
7124 (TNF)
09150 Organismal Systems
09151 Immune system
04640 Hematopoietic cell lineage
7124 (TNF)
04620 Toll-like receptor signaling pathway
7124 (TNF)
04621 NOD-like receptor signaling pathway
7124 (TNF)
04622 RIG-I-like receptor signaling pathway
7124 (TNF)
04625 C-type lectin receptor signaling pathway
7124 (TNF)
04650 Natural killer cell mediated cytotoxicity
7124 (TNF)
04612 Antigen processing and presentation
7124 (TNF)
04660 T cell receptor signaling pathway
7124 (TNF)
04657 IL-17 signaling pathway
7124 (TNF)
04664 Fc epsilon RI signaling pathway
7124 (TNF)
09152 Endocrine system
04920 Adipocytokine signaling pathway
7124 (TNF)
09158 Development and regeneration
04380 Osteoclast differentiation
7124 (TNF)
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
7124 (TNF)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
7124 (TNF)
05170 Human immunodeficiency virus 1 infection
7124 (TNF)
05161 Hepatitis B
7124 (TNF)
05160 Hepatitis C
7124 (TNF)
05171 Coronavirus disease - COVID-19
7124 (TNF)
05164 Influenza A
7124 (TNF)
05168 Herpes simplex virus 1 infection
7124 (TNF)
05163 Human cytomegalovirus infection
7124 (TNF)
05169 Epstein-Barr virus infection
7124 (TNF)
05165 Human papillomavirus infection
7124 (TNF)
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
7124 (TNF)
05132 Salmonella infection
7124 (TNF)
05131 Shigellosis
7124 (TNF)
05135 Yersinia infection
7124 (TNF)
05133 Pertussis
7124 (TNF)
05134 Legionellosis
7124 (TNF)
05152 Tuberculosis
7124 (TNF)
09174 Infectious disease: parasitic
05146 Amoebiasis
7124 (TNF)
05144 Malaria
7124 (TNF)
05145 Toxoplasmosis
7124 (TNF)
05140 Leishmaniasis
7124 (TNF)
05142 Chagas disease
7124 (TNF)
05143 African trypanosomiasis
7124 (TNF)
09163 Immune disease
05310 Asthma
7124 (TNF)
05322 Systemic lupus erythematosus
7124 (TNF)
05323 Rheumatoid arthritis
7124 (TNF)
05321 Inflammatory bowel disease
7124 (TNF)
05330 Allograft rejection
7124 (TNF)
05332 Graft-versus-host disease
7124 (TNF)
09164 Neurodegenerative disease
05010 Alzheimer disease
7124 (TNF)
05014 Amyotrophic lateral sclerosis
7124 (TNF)
05020 Prion disease
7124 (TNF)
05022 Pathways of neurodegeneration - multiple diseases
7124 (TNF)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
7124 (TNF)
05418 Fluid shear stress and atherosclerosis
7124 (TNF)
05410 Hypertrophic cardiomyopathy
7124 (TNF)
05414 Dilated cardiomyopathy
7124 (TNF)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
7124 (TNF)
04940 Type I diabetes mellitus
7124 (TNF)
04936 Alcoholic liver disease
7124 (TNF)
04932 Non-alcoholic fatty liver disease
7124 (TNF)
04931 Insulin resistance
7124 (TNF)
04933 AGE-RAGE signaling pathway in diabetic complications
7124 (TNF)
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
7124 (TNF)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04052 Cytokines and neuropeptides [BR:
hsa04052
]
7124 (TNF)
00536 Glycosaminoglycan binding proteins [BR:
hsa00536
]
7124 (TNF)
Cytokines and neuropeptides [BR:
hsa04052
]
Cytokines
Tumor necrosis fators
7124 (TNF)
Glycosaminoglycan binding proteins [BR:
hsa00536
]
Heparan sulfate / Heparin
Cytokines
7124 (TNF)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
TNF
Motif
Other DBs
NCBI-GeneID:
7124
NCBI-ProteinID:
NP_000585
OMIM:
191160
HGNC:
11892
Ensembl:
ENSG00000232810
UniProt:
P01375
Q5STB3
Structure
PDB
PDBj
LinkDB
All DBs
Position
6:31575565..31578336
Genome browser
AA seq
233 aa
AA seq
DB search
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
NT seq
702 nt
NT seq
+upstream
nt +downstream
nt
atgagcactgaaagcatgatccgggacgtggagctggccgaggaggcgctccccaagaag
acaggggggccccagggctccaggcggtgcttgttcctcagcctcttctccttcctgatc
gtggcaggcgccaccacgctcttctgcctgctgcactttggagtgatcggcccccagagg
gaagagttccccagggacctctctctaatcagccctctggcccaggcagtcagatcatct
tctcgaaccccgagtgacaagcctgtagcccatgttgtagcaaaccctcaagctgagggg
cagctccagtggctgaaccgccgggccaatgccctcctggccaatggcgtggagctgaga
gataaccagctggtggtgccatcagagggcctgtacctcatctactcccaggtcctcttc
aagggccaaggctgcccctccacccatgtgctcctcacccacaccatcagccgcatcgcc
gtctcctaccagaccaaggtcaacctcctctctgccatcaagagcccctgccagagggag
accccagagggggctgaggccaagccctggtatgagcccatctatctgggaggggtcttc
cagctggagaagggtgaccgactcagcgctgagatcaatcggcccgactatctcgacttt
gccgagtctgggcaggtctactttgggatcattgccctgtga
DBGET
integrated database retrieval system
