KEGG   ORTHOLOGY: K03156
Entry
K03156                      KO                                     

Symbol
TNF, TNFA
Name
tumor necrosis factor superfamily, member 2
Pathway
map01523  Antifolate resistance
map04010  MAPK signaling pathway
map04060  Cytokine-cytokine receptor interaction
map04061  Viral protein interaction with cytokine and cytokine receptor
map04064  NF-kappa B signaling pathway
map04071  Sphingolipid signaling pathway
map04150  mTOR signaling pathway
map04210  Apoptosis
map04217  Necroptosis
map04350  TGF-beta signaling pathway
map04380  Osteoclast differentiation
map04612  Antigen processing and presentation
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04625  C-type lectin receptor signaling pathway
map04640  Hematopoietic cell lineage
map04650  Natural killer cell mediated cytotoxicity
map04657  IL-17 signaling pathway
map04660  T cell receptor signaling pathway
map04664  Fc epsilon RI signaling pathway
map04668  TNF signaling pathway
map04920  Adipocytokine signaling pathway
map04930  Type II diabetes mellitus
map04931  Insulin resistance
map04932  Non-alcoholic fatty liver disease
map04933  AGE-RAGE signaling pathway in diabetic complications
map04936  Alcoholic liver disease
map04940  Type I diabetes mellitus
map05010  Alzheimer disease
map05014  Amyotrophic lateral sclerosis
map05020  Prion disease
map05022  Pathways of neurodegeneration - multiple diseases
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05133  Pertussis
map05134  Legionellosis
map05135  Yersinia infection
map05140  Leishmaniasis
map05142  Chagas disease
map05143  African trypanosomiasis
map05144  Malaria
map05145  Toxoplasmosis
map05146  Amoebiasis
map05152  Tuberculosis
map05160  Hepatitis C
map05161  Hepatitis B
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05205  Proteoglycans in cancer
map05310  Asthma
map05321  Inflammatory bowel disease
map05322  Systemic lupus erythematosus
map05323  Rheumatoid arthritis
map05330  Allograft rejection
map05332  Graft-versus-host disease
map05410  Hypertrophic cardiomyopathy
map05414  Dilated cardiomyopathy
map05417  Lipid and atherosclerosis
map05418  Fluid shear stress and atherosclerosis
Disease
H00079  Asthma
H00080  Systemic lupus erythematosus
H00083  Allograft rejection
H00084  Graft-versus-host disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04350 TGF-beta signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04064 NF-kappa B signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04668 TNF signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04071 Sphingolipid signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04150 mTOR signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04061 Viral protein interaction with cytokine and cytokine receptor
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04217 Necroptosis
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04620 Toll-like receptor signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04621 NOD-like receptor signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04622 RIG-I-like receptor signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04625 C-type lectin receptor signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04650 Natural killer cell mediated cytotoxicity
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04612 Antigen processing and presentation
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04660 T cell receptor signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04657 IL-17 signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04664 Fc epsilon RI signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05170 Human immunodeficiency virus 1 infection
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05161 Hepatitis B
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05160 Hepatitis C
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05171 Coronavirus disease - COVID-19
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05164 Influenza A
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05168 Herpes simplex virus 1 infection
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05163 Human cytomegalovirus infection
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05169 Epstein-Barr virus infection
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05165 Human papillomavirus infection
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05132 Salmonella infection
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05131 Shigellosis
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05135 Yersinia infection
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05133 Pertussis
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05134 Legionellosis
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05152 Tuberculosis
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05144 Malaria
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05145 Toxoplasmosis
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05140 Leishmaniasis
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05142 Chagas disease
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05143 African trypanosomiasis
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
  09163 Immune disease
   05310 Asthma
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05322 Systemic lupus erythematosus
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05323 Rheumatoid arthritis
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05321 Inflammatory bowel disease
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05330 Allograft rejection
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05332 Graft-versus-host disease
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05014 Amyotrophic lateral sclerosis
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05020 Prion disease
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05022 Pathways of neurodegeneration - multiple diseases
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05418 Fluid shear stress and atherosclerosis
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05410 Hypertrophic cardiomyopathy
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05414 Dilated cardiomyopathy
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04940 Type I diabetes mellitus
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04936 Alcoholic liver disease
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04932 Non-alcoholic fatty liver disease
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04931 Insulin resistance
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04933 AGE-RAGE signaling pathway in diabetic complications
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   00536 Glycosaminoglycan binding proteins
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
Cytokines and growth factors [BR:ko04052]
 Cytokines
  Tumor necrosis fators
   K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Cytokines
   K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
Other DBs
GO: 0005164
Genes
HSA: 7124(TNF)
PTR: 494186(TNF)
PPS: 100977674(TNF)
PON: 100447558(TNF)
NLE: 100583968(TNF)
MCC: 715467(TNF)
MCF: 102139631(TNF)
CATY: 105573465(TNF)
RRO: 104661913(TNF)
RBB: 108520255(TNF)
TFN: 117086926(TNF)
PTEH: 111523940(TNF)
CJC: 100397484(TNF)
SBQ: 101031357(TNF)
MMUR: 105858137(TNF)
MMU: 21926(Tnf)
MCAL: 110284110(Tnf)
MPAH: 110335791(Tnf)
RNO: 24835(Tnf)
MCOC: 116074547(Tnf)
MUN: 110560136(Tnf)
CGE: 100764780(Tnf)
PLEU: 114705817(Tnf)
NGI: 103724452(Tnf)
HGL: 101718432(Tnf)
CCAN: 109690391(Tnf)
OCU: 100009088(TNF)
TUP: 102497973(TNF)
CFA: 403922(TNF)
VVP: 112913803(TNF)
VLG: 121500453(TNF)
AML: 100471563(TNF)
UMR: 103682322(TNF)
UAH: 113243711(TNF)
ORO: 101368209(TNF)
ELK: 111152248
MPUF: 101687148(TNF)
EJU: 114222242(TNF)
MLX: 118027255(TNF)
FCA: 493755(TNF)
PYU: 121022312(TNF)
PBG: 122478253(TNF)
PTG: 102958919(TNF)
PPAD: 109260532(TNF)
AJU: 106983958(TNF)
HHV: 120221913(TNF)
BTA: 280943(TNF)
BOM: 102277911(TNF)
BIU: 109577428(TNF)
BBUB: 102392112(TNF)
CHX: 100861232(TNF)
OAS: 443540(TNF)
ODA: 120870534(TNF)
CCAD: 122430072(TNF)
SSC: 397086(TNF)
CFR: 102510424(TNF)
CBAI: 105074074(TNF)
CDK: 105087473(TNF)
BACU: 103005897(TNF)
LVE: 103083231(TNF)
OOR: 101269870(TNF)
DLE: 111170657(TNF)
PCAD: 102983069(TNF)
ECB: 100033834(TNF)
EPZ: 103562469(TNF)
EAI: 106825034(TNF)
MYB: 102246703(TNF)
MYD: 102758774(TNF)
MMYO: 118679652
MNA: 107538974(TNF)
HAI: 109373073(TNF)
DRO: 112302067(TNF)
SHON: 118987585(TNF)
AJM: 119053704(TNF)
MMF: 118621647(TNF)
PALE: 102887632(TNF)
PGIG: 120618944(TNF)
RAY: 107498497(TNF)
MJV: 108397877(TNF)
TOD: 119253235(TNF)
LAV: 100677125(TNF)
TMU: 101342656(TNF)
MDO: 100023069(TNF)
SHR: 100921875(TNF)
PCW: 110199397(TNF)
OAA: 100085643(TNF)
LSR: 110483403
OTC: 121340076
ASN: 102378738
AMJ: 102569751(TNF)
PSS: 102449532(TNF)
CMY: 102936332(TNF)
CPIC: 101949059(TNF)
CABI: 116822853(TNF)
PVT: 110069889(TNF)
PBI: 103052729
PMUR: 107296549
TSR: 106544745
PGUT: 117667868(TNF)
PMUA: 114592791
ZVI: 118076151(TNF)
GJA: 107119827
XLA: 100137625(tnf.L) 108700235(tnf.S)
XTR: 100134991(tnf)
NPR: 108793742
DRE: 405785(tnfa)
SANH: 107694347
SGH: 107597453
CCAR: 109063472
IPU: 100304592(tnf)
AMEX: 103032568
EEE: 113586401
TRU: 654303(tnfa)
ELY: 117263947 117265588(tnfb)
PLEP: 121957935(tnfa)
ECRA: 117957260
PFLV: 114568210
GAT: 120826067(tnfa)
MSAM: 119897144 119906688(tnfa)
CUD: 121524178(tnfa)
OLA: 101172593
OML: 112139461 112161658(tnfa)
XCO: 114156470
XHE: 116731887
PRET: 103472136
CVG: 107104043
CTUL: 119784060(tnfa)
KMR: 108248581(tnfa)
ALIM: 106512019
CSEM: 103394480
POV: 109640782
XGL: 120784265(tnfb) 120786357(tnfa)
BPEC: 110168066
MALB: 109974719
SASA: 100136457(tnf-alpha-1) 100136458(tnf-alpha-2) 100136509
OMY: 100136034(tnf-alpha) 100136064(tnf) 110487867(tnfa) 110496727
SNH: 120022601(tnfa) 120027290
ELS: 105031348
SFM: 108935614
PKI: 111838992
LCM: 102357196(TNF)
GAE: 121375624
PDAM: 113667221
 » show all
Reference
PMID:9089109
  Authors
Iraqi F, Teale A
  Title
Cloning and sequencing of the tnfa genes of three inbred mouse strains.
  Journal
Immunogenetics 45:459-61 (1997)
DOI:10.1007/s002510050233
  Sequence
[mmu:21926]
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