KEGG   DRUG: PegvisomantHelp
Entry
D05394                      Drug                                   

Name
Pegvisomant (USAN/INN);
Pegvisomant (genetical recombination) (JAN);
Somavent (TN)
Product
Sequence
FPTIPLSRLF DNAMLRADRL NQLAFDTYQE FEEAYIPKEQ KYSFLQNPQT SLCFSESIPT
PSNREETQQK SNLELLRISL LLIQSWLEPV QFLRSVFANS LVYGASDSNV YDLLKDLEEK
IQTLMGRLED GSPRTGQIFK QTYSKFDTNS HNDDALLKNY GLLYCFNADM SRVSTFLRTV
QCRSVEGSCG F
  Type
Peptide
Remark
Therapeutic category: 2499
ATC code: H01AX01
Product: D05394<JP/US>
Efficacy
Growth hormone receptor antagonist
  Disease
Acromegaly [DS:H01483]
Comment
Treatment of acromegaly (competitive inhibition of peripheral growth hormone receptors to block IFG-I production)
Target
GHR [HSA:2690] [KO:K05080]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04080  Neuroactive ligand-receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04630  JAK-STAT signaling pathway
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H01 PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
   H01A ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES
    H01AX Other anterior pituitary lobe hormones and analogues
     H01AX01 Pegvisomant
      D05394  Pegvisomant (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Suppressant (Pituitary)
  Pegvisomant
   D05394  Pegvisomant (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2499  Others
     D05394  Pegvisomant (USAN/INN); Pegvisomant (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   CSF and other factor receptors
    GHR
     D05394  Pegvisomant (USAN/INN) <JP/US>
Drug classes of therapeutic agents [br08360.html]
 Endocrine and hormonal agents
  D05394
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D05394
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D05394
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D05394
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D05394
BRITE hierarchy
Other DBs
CAS: 218620-50-9
PubChem: 47207070
DrugBank: DB00082
NIKKAJI: J2.535.243B
LinkDB All DBs

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